Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones
1
Taras Shevchenko Kiev National University, Kiev
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2
Gerontology Institute, Academy of Medical Sciences of the Ukraine, Kiev
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3
Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of the Ukraine, Kiev
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Publication type: Journal Article
Publication date: 2002-01-01
scimago Q3
wos Q4
SJR: 0.296
CiteScore: 1.3
Impact factor: 0.9
ISSN: 00093130, 15738388
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Plant Science
Abstract
Condensation of 1- and 3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-ones with substituted 1,1- diaminomethanes produced Mannich bases containing a dialkylaminomethyl group in the 2- and 4-positions of 7,8,9,10-tetrahydrobenzo[c]chromen-6-one. Pharmacological screening of 2-chloro-3-hydroxy-4-(1- pyrrolidinylmethyl)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one in Wistar rats showed that it possesses low toxicity and acts as a stimulant of the central and peripheral nervous systems with indications of neuroleptic and tranquilizing activities.
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Garazd Ya. L. et al. Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones // Chemistry of Natural Compounds. 2002. Vol. 38. No. 6. pp. 532-538.
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Garazd Ya. L., Panteleimonova T. N., Garazd M. M., Khilya V. P. Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones // Chemistry of Natural Compounds. 2002. Vol. 38. No. 6. pp. 532-538.
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TY - JOUR
DO - 10.1023/a:1022674318345
UR - https://doi.org/10.1023/a:1022674318345
TI - Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones
T2 - Chemistry of Natural Compounds
AU - Garazd, Ya L
AU - Panteleimonova, T N
AU - Garazd, M M
AU - Khilya, V P
PY - 2002
DA - 2002/01/01
PB - Springer Nature
SP - 532-538
IS - 6
VL - 38
SN - 0009-3130
SN - 1573-8388
ER -
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BibTex (up to 50 authors)
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@article{2002_Garazd,
author = {Ya L Garazd and T N Panteleimonova and M M Garazd and V P Khilya},
title = {Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones},
journal = {Chemistry of Natural Compounds},
year = {2002},
volume = {38},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1023/a:1022674318345},
number = {6},
pages = {532--538},
doi = {10.1023/a:1022674318345}
}
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MLA
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Garazd, Ya. L., et al. “Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones.” Chemistry of Natural Compounds, vol. 38, no. 6, Jan. 2002, pp. 532-538. https://doi.org/10.1023/a:1022674318345.