Nature, volume 390, issue 6655, pages 45-51
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o
1
,
YUTAKA MATSUMURA
1, 2
,
Hiroki AIZAWA
1, 2
,
Hiroshi Kawaguchi
3
,
Tatsuo SUGA
2
,
Toshihiro UTSUGI
2
,
Yoshio Ohyama
2
,
Masahiko KURABAYASHI
2
,
Tadashi Kaname
4
,
Eisuke Kume
5
,
Hitoshi Iwasaki
5
,
Akihiro Iida
6
,
Takako Shiraki-Iida
1, 6
,
Satoshi Nishikawa
7
,
Ryozo Nagai
2, 8
,
Yo-ichi Nabeshima
1, 8, 9
2
The 2nd Department of Internal Medicine, University of Gunma School of Medicine, Maebashi, Japan
|
5
Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Japan
|
6
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd, Machidashi, Japan
|
7
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd, Nagaizumi, Sunto, Japan
|
8
Core Research for Evolutional Science & Technology (CREST), JRDC and,
Publication type: Journal Article
Publication date: 1997-11-06
DOI:
10.1038/36285
PubMed ID:
9363890
Multidisciplinary
Abstract
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
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