volume 12 issue 8 pages 557-569

Cross-presentation by dendritic cells

Olivier P Joffre 1, 2
Elodie Segura 1, 2
Ariel Savina 1, 2
Sebastian Amigorena 1, 2
Publication typeJournal Article
Publication date2012-07-13
scimago Q1
wos Q1
SJR17.458
CiteScore84.7
Impact factor60.9
ISSN14741733, 14741741
PubMed ID:  22790179
Energy Engineering and Power Technology
Fuel Technology
Abstract
This Review integrates recent evidence regarding the intracellular trafficking pathways involved in cross-presentation into our understanding of the role of cross-presentation in immunity and tolerance. The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways. Here, we summarize recent advances in our understanding of the intracellular mechanisms of cross-presentation and discuss its role in immunity and tolerance in the context of specialization between DC subsets. Finally, we review current strategies to use cross-presentation for immunotherapy.
Found 
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GOST Copy
Joffre O. P. et al. Cross-presentation by dendritic cells // Nature Reviews Immunology. 2012. Vol. 12. No. 8. pp. 557-569.
GOST all authors (up to 50) Copy
Joffre O. P., Segura E., Savina A., Amigorena S. Cross-presentation by dendritic cells // Nature Reviews Immunology. 2012. Vol. 12. No. 8. pp. 557-569.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/nri3254
UR - https://doi.org/10.1038/nri3254
TI - Cross-presentation by dendritic cells
T2 - Nature Reviews Immunology
AU - Joffre, Olivier P
AU - Segura, Elodie
AU - Savina, Ariel
AU - Amigorena, Sebastian
PY - 2012
DA - 2012/07/13
PB - Springer Nature
SP - 557-569
IS - 8
VL - 12
PMID - 22790179
SN - 1474-1733
SN - 1474-1741
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2012_Joffre,
author = {Olivier P Joffre and Elodie Segura and Ariel Savina and Sebastian Amigorena},
title = {Cross-presentation by dendritic cells},
journal = {Nature Reviews Immunology},
year = {2012},
volume = {12},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038/nri3254},
number = {8},
pages = {557--569},
doi = {10.1038/nri3254}
}
MLA
Cite this
MLA Copy
Joffre, Olivier P., et al. “Cross-presentation by dendritic cells.” Nature Reviews Immunology, vol. 12, no. 8, Jul. 2012, pp. 557-569. https://doi.org/10.1038/nri3254.