Molecular Psychiatry, volume 25, issue 11, pages 2952-2969

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Yu Qianhui ^{1, 2}

He Zhisong ^{1, 3}

Zubkov Dmitry ³

HUANG SHUYUN ^{1, 4}

Kurochkin Ilia ³

Yang Xiaode ^{1, 2}

Halene Tobias ⁵

Willmitzer Lothar ⁶

Giavalisco Patrick ⁶

Akbarian S ⁵

Khaitovich Philipp ^{3, 4, 7, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

CAS Key Laboratory of Compstudy has been deposited in the National Omics Datautational Biology, CAS-MPG Partner Institute for Computational Biology, SIBS, CAS, Shanghai, China |

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China |

Skolkovo Institute of Science and technology, Moscow, Russia |

⁴

ShanghaiTech university, Shanghai, China |

⁵

Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA |

⁶

Max Planck Institute for Molecular Plant Physiology, Potsdam, Germany |

⁷

Comparative Biology Group, CAS-MPG Partner Institute for Computational Biology, SIBS, CAS, Shanghai, China |

⁸

Max Planck Institute For Evolutionary Anthropology, Leipzig, Germany |

Publication type: Journal Article

Publication date: 2018-08-08

Springer Nature

Journal: Molecular Psychiatry

Quartile SCImago

Quartile WOS

Impact factor: 11

ISSN: 13594184, 14765578

DOI: 10.1038/s41380-018-0200-8

Copy DOI

PubMed ID: 30089790

Molecular Biology

Cellular and Molecular Neuroscience

Psychiatry and Mental health

Abstract

Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down syndrome (DS). Of the 5024 detected lipids, 95% showed significant age-dependent concentration differences clustering into four temporal stages, and resulting in a gradual increase in membrane fluidity in individuals ranging from newborn to nonagenarian. Aging affects 14% of the brain lipidome with late-life changes starting predominantly at 50–55 years of age—a period of general metabolic transition. All three diseases alter the brain lipidome composition, leading—among other things—to a concentration decrease in glycerophospholipid metabolism and endocannabinoid signaling pathways. Lipid concentration decreases in SZ were further linked to genetic variants associated with disease, indicating the relevance of the lipidome changes to disease progression.

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Citations by journals

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Schizophrenia Bulletin	Schizophrenia Bulletin, 2, 3.33% Schizophrenia Bulletin 2 publications, 3.33%
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Nucleic Acids Research	Nucleic Acids Research, 1, 1.67% Nucleic Acids Research 1 publication, 1.67%
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Frontiers in Molecular Neuroscience	Frontiers in Molecular Neuroscience, 1, 1.67% Frontiers in Molecular Neuroscience 1 publication, 1.67%
Frontiers in Neuroscience	Frontiers in Neuroscience, 1, 1.67% Frontiers in Neuroscience 1 publication, 1.67%
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Frontiers in Psychiatry	Frontiers in Psychiatry, 1, 1.67% Frontiers in Psychiatry 1 publication, 1.67%
Frontiers in Nutrition	Frontiers in Nutrition, 1, 1.67% Frontiers in Nutrition 1 publication, 1.67%
Molecular Neurobiology	Molecular Neurobiology, 1, 1.67% Molecular Neurobiology 1 publication, 1.67%
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Experimental Neurology	Experimental Neurology, 1, 1.67% Experimental Neurology 1 publication, 1.67%
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Journal of Advanced Research	Journal of Advanced Research, 1, 1.67% Journal of Advanced Research 1 publication, 1.67%
Progress in Neuro-Psychopharmacology and Biological Psychiatry	Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1, 1.67% Progress in Neuro-Psychopharmacology and Biological Psychiatry 1 publication, 1.67%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 1.67% Biomedicine and Pharmacotherapy 1 publication, 1.67%
Current Opinion in Neurobiology	Current Opinion in Neurobiology, 1, 1.67% Current Opinion in Neurobiology 1 publication, 1.67%
Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 1, 1.67% Biochemical and Biophysical Research Communications 1 publication, 1.67%
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Citations by publishers

	2 4 6 8 10 12
Springer Nature	Springer Nature, 12, 20% Springer Nature 12 publications, 20%
Elsevier	Elsevier, 11, 18.33% Elsevier 11 publications, 18.33%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 10, 16.67% Multidisciplinary Digital Publishing Institute (MDPI) 10 publications, 16.67%
Frontiers Media S.A.	Frontiers Media S.A., 10, 16.67% Frontiers Media S.A. 10 publications, 16.67%
Oxford University Press	Oxford University Press, 3, 5% Oxford University Press 3 publications, 5%
Wiley	Wiley, 2, 3.33% Wiley 2 publications, 3.33%
Taylor & Francis	Taylor & Francis, 2, 3.33% Taylor & Francis 2 publications, 3.33%
Mary Ann Liebert	Mary Ann Liebert, 1, 1.67% Mary Ann Liebert 1 publication, 1.67%
Cairo University	Cairo University, 1, 1.67% Cairo University 1 publication, 1.67%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 1.67% American Chemical Society (ACS) 1 publication, 1.67%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.67% American Association for the Advancement of Science (AAAS) 1 publication, 1.67%
State Research Institute for Genetics and Selection of Industrial Microorganisms	State Research Institute for Genetics and Selection of Industrial Microorganisms, 1, 1.67% State Research Institute for Genetics and Selection of Industrial Microorganisms 1 publication, 1.67%
	2 4 6 8 10 12

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Yu Q. et al. Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders // Molecular Psychiatry. 2018. Vol. 25. No. 11. pp. 2952-2969.

GOST all authors (up to 50) Copy

Yu Q., He Z., Zubkov D., HUANG S., Kurochkin I., Yang X., Halene T., Willmitzer L., Giavalisco P., Akbarian S., Khaitovich P. Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders // Molecular Psychiatry. 2018. Vol. 25. No. 11. pp. 2952-2969.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41380-018-0200-8

UR - https://doi.org/10.1038%2Fs41380-018-0200-8

TI - Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

T2 - Molecular Psychiatry

AU - Yu, Qianhui

AU - He, Zhisong

AU - Zubkov, Dmitry

AU - HUANG, SHUYUN

AU - Kurochkin, Ilia

AU - Yang, Xiaode

AU - Halene, Tobias

AU - Willmitzer, Lothar

AU - Giavalisco, Patrick

AU - Akbarian, S

AU - Khaitovich, Philipp

PY - 2018

DA - 2018/08/08 00:00:00

PB - Springer Nature

SP - 2952-2969

IS - 11

VL - 25

PMID - 30089790

SN - 1359-4184

SN - 1476-5578

ER -

BibTex |

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BibTex Copy

@article{2018_Yu,

author = {Qianhui Yu and Zhisong He and Dmitry Zubkov and SHUYUN HUANG and Ilia Kurochkin and Xiaode Yang and Tobias Halene and Lothar Willmitzer and Patrick Giavalisco and S Akbarian and Philipp Khaitovich},

title = {Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders},

journal = {Molecular Psychiatry},

year = {2018},

volume = {25},

publisher = {Springer Nature},

month = {aug},

url = {https://doi.org/10.1038%2Fs41380-018-0200-8},

number = {11},

pages = {2952--2969},

doi = {10.1038/s41380-018-0200-8}

}

MLA

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Yu., Qianhui, et al. “Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders.” Molecular Psychiatry, vol. 25, no. 11, Aug. 2018, pp. 2952-2969. https://doi.org/10.1038%2Fs41380-018-0200-8.

Found error?

Publisher

Springer Nature

Journal

Molecular Psychiatry

Quartile SCImago

Quartile WOS

Impact factor

ISSN

13594184 (Print)
14765578 (Electronic)

Labs

Laboratory of Molecular Neuroscience

Profiles

Khaitovich, Philipp E