Springer Nature
Bone Marrow Transplantation
,  volume 58 ,  issue 5 ,  pages 534-543

Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

Claire Michel 1
, 
Marie Robin 2
, 
Stephane Morisset 3
, 
D. Blaise 4
, 
Johan Maertens 5
, 
Patrice Chevalier 6
, 
Cristina Castilla-Llorente 7
, 
E. Forcade 8
, 
Patrice Ceballos 9
, 
Ibrahim Yakoub-Agha 10
, 
Xavier Poire 11
, 
Martin Carre 12
, 
Jacques-Olivier Bay 13
, 
Yves Beguin 14
, 
M. Loschi 15
, 
Anne Huynh 16
, 
Gaëlle Guillerm 17
, 
Sylvie François 18
, 
Jean-Baptiste Mear 19
, 
R. Dulery 20
, 
Felipe Suarez 21
, 
Karin Bilger 22
, 
J. Cornillon 23
, 
Y Chalandon 24
, 
Natacha Maillard 25
, 
Hélène Labussière-Wallet 26
, 
Amandine Charbonnier 27
, 
Pascal Turlure 28
, 
Ana Berceanu 29
, 
Sylvain Chantepie 30
, 
Sébastien Maury 31
, 
Ali Bazarbachi 32
, 
Anne-Lise Menard 33
, 
Stephanie Nguyen-Quoc 34
, 
Marie-Thérèse Rubio 1
, 
Maud D’Aveni 1
1
 
2
 
Hematology department, Hôpital Saint-Louis, Paris, France | 
3
 
Biostatistics Consultant, Pérouges, France | 
4
 
Hematology Department, Institut Paoli Calmette, Marseille, France | 
5
 
6
 
7
 
8
 
Hematology department, Hôpital Haut-Levêque, Bordeaux, France | 
9
 
Hematology department, Hôpital Saint Eloi, Montpellier, France | 
10
 
11
 
Section of Hematology, Cliniques Universitaires St-Luc, Brussels, Belgium | 
12
 
Hematology department, Hôpital Michallon, Grenoble, France | 
13
 
14
 
Hematology department, University hospital of Liège, Liège, Belgium | 
15
 
Hematology department Hôpital l’Archet, Nice, France | 
16
 
17
 
18
 
19
 
20
 
Hematology department, Hôpital Saint-Antoine, Paris, France | 
21
 
22
 
23
 
24
 
25
 
26
 
27
 
28
 
Hematology department, Hôpital Dupuytren, Limoges, France | 
29
 
30
 
31
 
Hematology Department, Hôpital Henri Mondor, Créteil, France | 
32
 
Hematology department, American university of Beyrouth, Beyrouth, Lebanon | 
33
 
Hematology department Centre Henri Bequerel, Rouen, France | 
34
 
Hematology department, Hôpital La Pitié Salpêtrière, Paris, France | 
Publication type: Journal Article
Publication date: 2023-02-11
Springer Nature
scimago Q1
wos Q1
SJR: 1.709
CiteScore: 8.4
Impact factor: 5.2
ISSN: 02683369, 14765365
Hematology
Transplantation
Abstract

Allogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups (p < 0.001). The overall survival was significantly different between the three groups with a better OS observed in the MUD group (p = 0.014). This observation could be explained by a higher progression-free survival with MUD (p = 0.014). The cumulative incidence of grade 2–4 acute GvHD was significantly higher in the HID group (p = 0.051). However, in multivariable analysis, patients transplanted using an HID had comparable mortality to patients transplanted using a MUD (subdistribution hazard ratio [sHR]: 0.58 [0.32–1.07]; p = 0.080) and a MSD ([sHR]: 0.56 [0.28–1.11]; p = 0.094). MUD do not remain a significant positive predictor of survival, suggesting that beyond the donor-recipient HLA matching, the donor age might impact recipient outcome.

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GOST Copy
Michel C. et al. Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS // Bone Marrow Transplantation. 2023. Vol. 58. No. 5. pp. 534-543.
GOST all authors (up to 50) Copy
Michel C., Robin M., Morisset S., Blaise D., Maertens J., Chevalier P., Castilla-Llorente C., Forcade E., Ceballos P., Yakoub-Agha I., Poire X., Carre M., Bay J., Beguin Y., Loschi M., Huynh A., Guillerm G., François S., Mear J., Dulery R., Suarez F., Bilger K., Cornillon J., Chalandon Y., Maillard N., Labussière-Wallet H., Charbonnier A., Turlure P., Berceanu A., Chantepie S., Maury S., Bazarbachi A., Menard A., Nguyen-Quoc S., Rubio M., D’Aveni M. Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS // Bone Marrow Transplantation. 2023. Vol. 58. No. 5. pp. 534-543.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41409-023-01931-7
UR - https://doi.org/10.1038/s41409-023-01931-7
TI - Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS
T2 - Bone Marrow Transplantation
AU - Michel, Claire
AU - Robin, Marie
AU - Morisset, Stephane
AU - Blaise, D.
AU - Maertens, Johan
AU - Chevalier, Patrice
AU - Castilla-Llorente, Cristina
AU - Forcade, E.
AU - Ceballos, Patrice
AU - Yakoub-Agha, Ibrahim
AU - Poire, Xavier
AU - Carre, Martin
AU - Bay, Jacques-Olivier
AU - Beguin, Yves
AU - Loschi, M.
AU - Huynh, Anne
AU - Guillerm, Gaëlle
AU - François, Sylvie
AU - Mear, Jean-Baptiste
AU - Dulery, R.
AU - Suarez, Felipe
AU - Bilger, Karin
AU - Cornillon, J.
AU - Chalandon, Y
AU - Maillard, Natacha
AU - Labussière-Wallet, Hélène
AU - Charbonnier, Amandine
AU - Turlure, Pascal
AU - Berceanu, Ana
AU - Chantepie, Sylvain
AU - Maury, Sébastien
AU - Bazarbachi, Ali
AU - Menard, Anne-Lise
AU - Nguyen-Quoc, Stephanie
AU - Rubio, Marie-Thérèse
AU - D’Aveni, Maud
PY - 2023
DA - 2023/02/11
PB - Springer Nature
SP - 534-543
IS - 5
VL - 58
PMID - 36774430
SN - 0268-3369
SN - 1476-5365
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Michel,
author = {Claire Michel and Marie Robin and Stephane Morisset and D. Blaise and Johan Maertens and Patrice Chevalier and Cristina Castilla-Llorente and E. Forcade and Patrice Ceballos and Ibrahim Yakoub-Agha and Xavier Poire and Martin Carre and Jacques-Olivier Bay and Yves Beguin and M. Loschi and Anne Huynh and Gaëlle Guillerm and Sylvie François and Jean-Baptiste Mear and R. Dulery and Felipe Suarez and Karin Bilger and J. Cornillon and Y Chalandon and Natacha Maillard and Hélène Labussière-Wallet and Amandine Charbonnier and Pascal Turlure and Ana Berceanu and Sylvain Chantepie and Sébastien Maury and Ali Bazarbachi and Anne-Lise Menard and Stephanie Nguyen-Quoc and Marie-Thérèse Rubio and Maud D’Aveni},
title = {Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS},
journal = {Bone Marrow Transplantation},
year = {2023},
volume = {58},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038/s41409-023-01931-7},
number = {5},
pages = {534--543},
doi = {10.1038/s41409-023-01931-7}
}
MLA
Cite this
MLA Copy
Michel, Claire, et al. “Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS.” Bone Marrow Transplantation, vol. 58, no. 5, Feb. 2023, pp. 534-543. https://doi.org/10.1038/s41409-023-01931-7.
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