Open Access
Open access
Springer Nature
Cell Death Discovery
,  volume 11 ,  issue 1 ,  publication number 28

Regulatory role of PPAR in colorectal cancer

Publication type: Journal Article
Publication date: 2025-01-28
Springer Nature
scimago Q1
wos Q1
SJR: 1.986
CiteScore: 10.7
Impact factor: 7.0
ISSN: 20587716
Abstract

Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the majority of patients are found to be in advanced stages, which is a burden to human health all over the world. Moreover, in recent years, CRC has been progressively becoming younger, with an increasing incidence mainly among patients <50 years old. Despite the increase in awareness of CRC and the continuous improvement of medical treatment nowadays, the challenge of CRC still needs to be conquered. By now, the pathogenesis of CRC is complex and not fully understood. With the deepening of research, it has been revealed that PPARs, as a transcription factor, are inextricably linked to CRC. This article outlines the mechanisms by which PPARs are involved in CRC development. An in-depth understanding of the pathways related to PPARs may provide new ways of developing effective therapies for CRC with PPARs as potential targets.

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GOST |
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GOST Copy
Wang C. et al. Regulatory role of PPAR in colorectal cancer // Cell Death Discovery. 2025. Vol. 11. No. 1. 28
GOST all authors (up to 50) Copy
Wang C., Lv T., Jin B., Li Y., Zhuang C. Regulatory role of PPAR in colorectal cancer // Cell Death Discovery. 2025. Vol. 11. No. 1. 28
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41420-025-02313-2
UR - https://www.nature.com/articles/s41420-025-02313-2
TI - Regulatory role of PPAR in colorectal cancer
T2 - Cell Death Discovery
AU - Wang, Cong
AU - Lv, Tingcong
AU - Jin, Binghui
AU - Li, Yang
AU - Zhuang, Chengjun
PY - 2025
DA - 2025/01/28
PB - Springer Nature
IS - 1
VL - 11
SN - 2058-7716
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Wang,
author = {Cong Wang and Tingcong Lv and Binghui Jin and Yang Li and Chengjun Zhuang},
title = {Regulatory role of PPAR in colorectal cancer},
journal = {Cell Death Discovery},
year = {2025},
volume = {11},
publisher = {Springer Nature},
month = {jan},
url = {https://www.nature.com/articles/s41420-025-02313-2},
number = {1},
pages = {28},
doi = {10.1038/s41420-025-02313-2}
}