Cellular and Molecular Immunology, volume 19, issue 2, pages 177-191

Neutrophils in chronic inflammatory diseases

Andrea Herrero-Cervera ¹

Oliver Soehnlein ^{1, 2}

Ellinor Kenne ²

Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster, Germany |

Department of Physiology and Pharmacology, Karolinska Institutet, STOCKHOLM, Sweden |

Publication type: Journal Article

Publication date: 2022-01-17

Springer Nature

Journal: Cellular and Molecular Immunology

scimago Q1

SJR: 4.838

CiteScore: 31.2

Impact factor: 21.8

ISSN: 16727681, 20420226

DOI: 10.1038/s41423-021-00832-3

Copy DOI

Infectious Diseases

Immunology

Immunology and Allergy

Abstract

Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide. Chronic inflammation is characterized by persistent, low-grade inflammation and is increased in the aging population. Neutrophils are normally the first responders to acute inflammation and contribute to the resolution of inflammation. However, in chronic inflammation, the role of neutrophils is less well understood and has been described as either beneficial or detrimental, causing tissue damage and enhancing the immune response. Emerging evidence suggests that neutrophils are important players in several chronic diseases, such as atherosclerosis, diabetes mellitus, nonalcoholic fatty liver disease and autoimmune disorders. This review will highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.

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