Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Publication type: Journal Article
Publication date: 2023-11-07
scimago Q1
wos Q1
SJR: 5.916
CiteScore: 36.2
Impact factor: 19.8
ISSN: 16727681, 20420226
PubMed ID:
37932533
Infectious Diseases
Immunology
Immunology and Allergy
Abstract
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate immune response to viral infection and other stress factors. The deregulation of these processes causes autoimmune diseases, inflammatory metabolic disorders and cancer. Therefore, the cGAS-MITA/STING pathway is a potential target for intervention in infectious, inflammatory and autoimmune diseases as well as cancer. In this review, we focus on the mechanisms underlying the mtDNA-triggered activation of the cGAS-MITA/STING pathway, the effects of the pathway under various physiological and pathological conditions, and advances in the development of drugs that target cGAS and MITA/STING.
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110
Total citations:
110
Citations from 2024:
109
(99.09%)
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GOST
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Shu H. et al. Mitochondrial DNA-triggered innate immune response: mechanisms and diseases // Cellular and Molecular Immunology. 2023. Vol. 20. No. 12. pp. 1403-1412.
GOST all authors (up to 50)
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Shu H., Shu H. Mitochondrial DNA-triggered innate immune response: mechanisms and diseases // Cellular and Molecular Immunology. 2023. Vol. 20. No. 12. pp. 1403-1412.
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RIS
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TY - JOUR
DO - 10.1038/s41423-023-01086-x
UR - https://doi.org/10.1038/s41423-023-01086-x
TI - Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
T2 - Cellular and Molecular Immunology
AU - Shu, Hong
AU - Shu, Hong-Bing
PY - 2023
DA - 2023/11/07
PB - Springer Nature
SP - 1403-1412
IS - 12
VL - 20
PMID - 37932533
SN - 1672-7681
SN - 2042-0226
ER -
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BibTex (up to 50 authors)
Copy
@article{2023_Shu,
author = {Hong Shu and Hong-Bing Shu},
title = {Mitochondrial DNA-triggered innate immune response: mechanisms and diseases},
journal = {Cellular and Molecular Immunology},
year = {2023},
volume = {20},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1038/s41423-023-01086-x},
number = {12},
pages = {1403--1412},
doi = {10.1038/s41423-023-01086-x}
}
Cite this
MLA
Copy
Shu, Hong, et al. “Mitochondrial DNA-triggered innate immune response: mechanisms and diseases.” Cellular and Molecular Immunology, vol. 20, no. 12, Nov. 2023, pp. 1403-1412. https://doi.org/10.1038/s41423-023-01086-x.