Open Access

Nature Communications

, volume 11 , issue 1 , publication number 597

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nikos Papadimitriou ¹

Niki Dimou ¹

Konstantinos Tsilidis ^{2, 3}

Barbara Banbury ⁴

Richard C. Martin ^{5, 6, 7}

Sarah J. Lewis ⁶

Nabila Kazmi ⁵

Timothy M Robinson ⁶

Demetrius Albanes ⁸

Krasimira Aleksandrova ⁹

Sonja I Berndt ⁸

D T Bishop ¹⁰

Hermann Brenner ^{11, 12, 13}

Daniel D Buchanan ^{14, 15, 16}

Bas Bueno-de-Mesquita ^{17, 18, 19, 20}

Peter T. Campbell ²¹

Sergi Castellvi-Bel ²²

Andrew Chan ^{23, 24}

Jenny Chang-Claude ^{25, 26}

Merete Ellingjord Dale ³

Jane C. Figueiredo ^{27, 28}

Steven J Gallinger ²⁹

G. R. Giles ^{14, 30}

Edward Giovannucci ^{31, 32, 33}

Stephen B. Gruber ³⁴

Andrea Gsur ³⁵

Jochen Hampe ³⁶

Heather Hampel ³⁷

Sophia Harlid ³⁸

Tabitha Harrison ⁴

Michael Hoffmeister ¹¹

John L. Hopper ^{14, 39}

Li Hsu ^{4, 40}

José María Huerta ^{41, 42}

Jeroen Huyghe ⁴

Mark W. Jenkins ¹⁴

Temitope O. Keku ⁴³

Tilman Kühn ²⁵

C La Vecchia ^{44, 45}

Loïc Le Marchand ⁴⁶

Christopher I. Li ⁴

Li Li ⁴⁷

Annika Lindblom ^{48, 49}

Noralane M. Lindor ⁵⁰

Brigid Lynch ^{14, 30, 51}

Sanford D. Markowitz ⁵²

Giovanna Masala ⁵³

Anne M. May ⁵⁴

R W Milne ^{14, 30, 55}

Evelyn Monninkhof ⁵⁴

Lorena Moreno ²²

Victor Moreno ^{41, 56, 57}

Polly Newcomb ^{4, 58}

Kenneth Offit ^{59, 60}

Vittorio Perduca ^{61, 62, 63}

P. O. D. PHAROAH ⁶⁴

Elizabeth A Platz ⁶⁵

John Potter ⁴

G Rennert ^{66, 67, 68}

Riboli Elio ³

María-José Sánchez ^{41, 69}

Stephanie Schmit ^{34, 70}

ROBERT EDWARD SCHOEN ⁷¹

Gianluca Severi ^{61, 62}

Sabina Sieri ⁷²

Martha L Slattery ⁷³

Mingyang Song ^{23, 24, 31, 32}

Catherine M. Tangen ⁷⁴

Stephen N. Thibodeau ⁷⁵

Ruth C. Travis ⁷⁶

Antonia Trichopoulou ⁴⁴

Cornelia M. Ulrich ⁷⁷

Fränzel J B Van Duijnhoven ⁷⁸

Bethany Van Guelpen ^{79, 80}

Pavel Vodicka ^{81, 82, 83}

Emily White ^{4, 84}

Alicja Wolk ⁸⁵

Michael O Woods ⁸⁶

Anna H. Wu ⁸⁷

Ulrike Peters ^{4, 84}

Marc J. Gunter ¹

Neil Murphy ¹

Hide authors affiliations Show authors affiliations: 87 affiliations

Section of Nutrition and Metabolism, International Agency for Research On Cancer, Lyon, France |

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece |

Department of Epidemiology and Biostatistics, School of Public health, Imperial College London, London, UK |

⁴

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA |

⁵

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK |

⁶

Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK |

⁷

National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK |

⁸

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA |

⁹

German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, Nuthetal, Germany |

¹⁰

Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK |

¹¹

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany |

¹²

Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany |

¹³

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany |

¹⁴

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia |

¹⁵

Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Australia |

¹⁶

Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Australia |

¹⁷

Former senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven, Netherlands |

¹⁸

Former associate professor, Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands |

¹⁹

Former visiting professor, Dept. of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary’s Campus, Norfolk Place, London, London, UK |

²⁰

Former academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia |

²¹

Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, USA |

²²

Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain

Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer

University of Barcelona

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

²³

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Harvard University

Massachusetts General Hospital

²⁴

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Harvard University

Massachusetts General Hospital

²⁵

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany |

²⁶

University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany

University Medical Center Hamburg-Eppendorf

University Cancer Center Hamburg

²⁷

Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA |

²⁸

Department of preventive medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA |

²⁹

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada |

³⁰

Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia |

³¹

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA |

³²

Department of Nutrition, T.H. H, Chan School of Public Health, Boston, USA |

³³

Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA

Harvard University

Brigham and Women's Hospital

³⁴

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA |

³⁵

Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria |

³⁶

Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany

Technische Universität Dresden

University Hospital Carl Gustav Carus

³⁷

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, USA |

³⁸

Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden |

³⁹

Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea |

⁴⁰

Department of Biostatistics, University of Washington, Seattle, USA |

⁴¹

CIBER de Epidemiología y Salud pública (CIBERESP), Madrid, Spain |

⁴²

Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain |

⁴³

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, USA |

⁴⁴

Hellenic Health Foundation, Athens, Greece |

⁴⁵

Dept. of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy |

⁴⁶

University of Hawaii cancer Center, Honolulu, USA |

⁴⁷

Department of Family Medicine, University of Virginia, Charlottesville, USA |

⁴⁸

Department of Clinical genetics, Karolinska University Hospital, Stockholm, Sweden |

⁴⁹

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden |

⁵⁰

Department of Health Science Research, Mayo Clinic, Scottsdale, USA |

⁵¹

Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia |

⁵²

Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, USA |

⁵³

Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy |

⁵⁴

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, UTRECHT, Netherlands |

⁵⁵

Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Australia |

⁵⁶

Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain

Bellvitge Biomedical Research Institute

Catalan Institute of Oncology

⁵⁷

Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain |

⁵⁸

School of Public Health, University of Washington, Seattle, USA |

⁵⁹

Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA |

⁶⁰

Department of Medicine, Weill Cornell Medical College, New York, USA |

⁶¹

CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ I, Université Paris-Saclay, Villejuif, France

University of Versailles Saint-Quentin-en-Yvelines

Université Paris-Saclay

⁶²

GUSTAVE ROUSSY, VILLEJUIF, France |

⁶³

Laboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France |

⁶⁴

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK |

⁶⁵

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA |

⁶⁶

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel |

⁶⁷

Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel |

⁶⁸

Clalit National Cancer Control Center, Haifa, Israel |

⁶⁹

Andalusian School of Public Health, Biomedical Research Institute ibs.GRANADA, University of Granada, Granada, Spain

University of Granada

Instituto de Investigación Biosanitaria de Granada

Andalusian School of Public Health

⁷⁰

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA |

⁷¹

Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, USA |

⁷²

Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy |

⁷³

Department of Internal Medicine, University of Utah, Salt Lake City, USA |

⁷⁴

SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, USA |

⁷⁵

Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA |

⁷⁶

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK |

⁷⁷

Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, USA |

⁷⁸

Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands |

⁷⁹

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden |

⁸⁰

Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden |

⁸¹

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic |

⁸²

Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic |

⁸³

Institute of Biology and Medical Genetics, First faculty of Medicine, Charles University, Prague, Czech Republic |

⁸⁴

Department of Epidemiology, University of Washington, Seattle, USA |

⁸⁵

Institute of Environmental Medicine, Karolinska institutet, Stockholm, Sweden |

⁸⁶

Memorial University of Newfoundland, Discipline of Genetics, St. John’s, Canada |

⁸⁷

University of Southern California, Preventative Medicine, Los Angeles, USA |

Publication type: Journal Article

Publication date: 2020-01-30

Springer Nature

Nature Communications

scimago Q1

wos Q1

SJR: 4.761

CiteScore: 23.4

Impact factor: 15.7

ISSN: 20411723

DOI: 10.1038/s41467-020-14389-8

Copy DOI

PubMed ID: 32001714

General Chemistry

General Biochemistry, Genetics and Molecular Biology

General Physics and Astronomy

Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

Found

1 citation

Annunziata Giuseppe

69 publications, 2 709 citations, 95 reviews

h-index: 27

University of Naples Federico II

University of Campania "Luigi Vanvitelli"

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Papadimitriou N. et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis // Nature Communications. 2020. Vol. 11. No. 1. 597

GOST all authors (up to 50) Copy

Papadimitriou N. et al. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis // Nature Communications. 2020. Vol. 11. No. 1. 597

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@article{2020_Papadimitriou,

author = {Nikos Papadimitriou and Niki Dimou and Konstantinos Tsilidis and Barbara Banbury and Richard C. Martin and Sarah J. Lewis and Nabila Kazmi and Timothy M Robinson and Demetrius Albanes and Krasimira Aleksandrova and Sonja I Berndt and D T Bishop and Hermann Brenner and Daniel D Buchanan and Bas Bueno-de-Mesquita and Peter T. Campbell and Sergi Castellvi-Bel and Andrew Chan and Jenny Chang-Claude and Merete Ellingjord Dale and Jane C. Figueiredo and Steven J Gallinger and G. R. Giles and Edward Giovannucci and Stephen B. Gruber and Andrea Gsur and Jochen Hampe and Heather Hampel and Sophia Harlid and Tabitha Harrison and Michael Hoffmeister and John L. Hopper and Li Hsu and José María Huerta and Jeroen Huyghe and Mark W. Jenkins and Temitope O. Keku and Tilman Kühn and C La Vecchia and Loïc Le Marchand and Christopher I. Li and Li Li and Annika Lindblom and Noralane M. Lindor and Brigid Lynch and Sanford D. Markowitz and Giovanna Masala and Anne M. May and R W Milne and Evelyn Monninkhof and others},

title = {Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis},

journal = {Nature Communications},

year = {2020},

volume = {11},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038/s41467-020-14389-8},

number = {1},

pages = {597},

doi = {10.1038/s41467-020-14389-8}

}

Publisher

Springer Nature

Journal

Nature Communications

scimago Q1

wos Q1

SJR

4.761

CiteScore

23.4

Impact factor

15.7

ISSN

20411723 (Print, Electronic)