Open Access
DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer
Maria Zhivagui
1, 2, 3
,
Areebah Hoda
1
,
Noelia Valenzuela
3
,
Yi-Yu Yeh
2
,
Jason Dai
2
,
Yudou He
1, 2, 3
,
Shuvro P. Nandi
1, 2, 3
,
Burcak Otlu
1, 2, 3
,
Bennett Van Houten
4
,
Ludmil Alexandrov
1, 2, 3
Publication type: Journal Article
Publication date: 2023-01-17
scimago Q1
wos Q1
SJR: 4.761
CiteScore: 23.4
Impact factor: 15.7
ISSN: 20411723
PubMed ID:
36650165
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Multidisciplinary
General Physics and Astronomy
Abstract
Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction. Analysis of somatic mutations reveals a dose-dependent increase of C:G>A:T substitutions in irradiated samples with mutagenic patterns similar to mutational signatures previously attributed to reactive oxygen species. In summary, this study demonstrates that radiation emitted by UV-nail polish dryers can both damage DNA and permanently engrave mutations on the genomes of primary mouse embryonic fibroblasts, human foreskin fibroblasts, and human epidermal keratinocytes.
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Metrics
32
Total citations:
32
Citations from 2024:
28
(90.32%)
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RIS |
BibTex
Cite this
GOST
Copy
Zhivagui M. et al. DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer // Nature Communications. 2023. Vol. 14. No. 1. 276
GOST all authors (up to 50)
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Zhivagui M., Hoda A., Valenzuela N., Yeh Y., Dai J., He Y., Nandi S. P., Otlu B., Van Houten B., Alexandrov L. DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer // Nature Communications. 2023. Vol. 14. No. 1. 276
Cite this
RIS
Copy
TY - JOUR
DO - 10.1038/s41467-023-35876-8
UR - https://doi.org/10.1038/s41467-023-35876-8
TI - DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer
T2 - Nature Communications
AU - Zhivagui, Maria
AU - Hoda, Areebah
AU - Valenzuela, Noelia
AU - Yeh, Yi-Yu
AU - Dai, Jason
AU - He, Yudou
AU - Nandi, Shuvro P.
AU - Otlu, Burcak
AU - Van Houten, Bennett
AU - Alexandrov, Ludmil
PY - 2023
DA - 2023/01/17
PB - Springer Nature
IS - 1
VL - 14
PMID - 36650165
SN - 2041-1723
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Zhivagui,
author = {Maria Zhivagui and Areebah Hoda and Noelia Valenzuela and Yi-Yu Yeh and Jason Dai and Yudou He and Shuvro P. Nandi and Burcak Otlu and Bennett Van Houten and Ludmil Alexandrov},
title = {DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer},
journal = {Nature Communications},
year = {2023},
volume = {14},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038/s41467-023-35876-8},
number = {1},
pages = {276},
doi = {10.1038/s41467-023-35876-8}
}
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