Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T1 imaging in 12 individuals with chronic schizophrenia and 14 healthy age-matched controls. In schizophrenia, there were higher QSM values in bilateral putamen and higher concentrations of phosphocreatine and lactate in caudal anterior cingulate cortex (caCC). Network-based correlation analysis of QSM across corticostriatal pathways as well as the correlation between QSM, MRS, and volume, showed distinct patterns between groups. This study introduces increased iron in the putamen in schizophrenia in addition to network-wide disturbances of iron and metabolic status.

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Cite this

GOST |

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GOST Copy

Ravanfar P. et al. In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia // Schizophrenia. 2022. Vol. 8. No. 1. 86

GOST all authors (up to 50) Copy

Ravanfar P., Syeda W. T., Jayaram M., Rushmore R. J., Moffat B., Lin A. P., Lyall A. E., Merritt A. H., Yaghmaie N., Laskaris L., Luza S., Opazo C. M., Liberg B., Chakravarty M. M., Devenyi G. A., Desmond P., Cropley V. L., Makris N., Shenton M. E., Bush A. I., Velakoulis D., Pantelis C. In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia // Schizophrenia. 2022. Vol. 8. No. 1. 86

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41537-022-00293-1

UR - https://doi.org/10.1038/s41537-022-00293-1

TI - In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia

T2 - Schizophrenia

AU - Ravanfar, Parsa

AU - Syeda, Warda T

AU - Jayaram, Mahesh

AU - Rushmore, R. Jarrett

AU - Moffat, Bradford

AU - Lin, A P.

AU - Lyall, A. E.

AU - Merritt, Antonia H

AU - Yaghmaie, Negin

AU - Laskaris, Liliana

AU - Luza, Sandra

AU - Opazo, Carlos M

AU - Liberg, Benny

AU - Chakravarty, M. Mallar

AU - Devenyi, Gabriel A.

AU - Desmond, Patricia

AU - Cropley, Vanessa L.

AU - Makris, Nikos

AU - Shenton, Martha E.

AU - Bush, Ashley I.

AU - Velakoulis, Dennis

AU - Pantelis, Christos

PY - 2022

DA - 2022/10/26

PB - Springer Nature

IS - 1

VL - 8

PMID - 36289238

SN - 2754-6993

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Ravanfar,

author = {Parsa Ravanfar and Warda T Syeda and Mahesh Jayaram and R. Jarrett Rushmore and Bradford Moffat and A P. Lin and A. E. Lyall and Antonia H Merritt and Negin Yaghmaie and Liliana Laskaris and Sandra Luza and Carlos M Opazo and Benny Liberg and M. Mallar Chakravarty and Gabriel A. Devenyi and Patricia Desmond and Vanessa L. Cropley and Nikos Makris and Martha E. Shenton and Ashley I. Bush and Dennis Velakoulis and Christos Pantelis},

title = {In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia},

journal = {Schizophrenia},

year = {2022},

volume = {8},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1038/s41537-022-00293-1},

number = {1},

pages = {86},

doi = {10.1038/s41537-022-00293-1}

}

Publisher

Springer Nature

Journal

Schizophrenia

wos Q1

SJR

—

CiteScore

—

Impact factor

4.1

ISSN

27546993 (Electronic)