Open Access

npj Vaccines

, volume 6 , issue 1 , publication number 23

A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus

Thomas W. Geisbert ^{1, 2}

Kathryn Bobb ³

Viktoriya Borisevich ^{1, 2}

Joan B. Geisbert ^{1, 2}

Krystle N Agans ^{1, 2}

Robert W. Cross ^{1, 2}

Abhishek N. Prasad ^{1, 2}

Karla A. Fenton ^{1, 2}

H. Yu ³

Timothy R. Fouts ³

Christopher C. Broder ⁴

Antony S Dimitrov ^{3, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

Galveston National Laboratory, University of Texas Medical Branch, Galveston, USA |

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, USA |

Profectus Biosciences, Inc., Baltimore, USA |

⁴

Department of Microbiology and Immunology, Uniformed Services University, Bethesda, USA |

Publication type: Journal Article

Publication date: 2021-02-08

Springer Nature

npj Vaccines

scimago Q1

wos Q1

SJR: 2.236

CiteScore: 11.6

Impact factor: 6.5

ISSN: 20590105

DOI: 10.1038/s41541-021-00284-w

Copy DOI

PubMed ID: 33558494

Pharmacology

Infectious Diseases

Pharmacology (medical)

Immunology

Abstract

Nipah and Hendra viruses are highly pathogenic bat-borne paramyxoviruses recently included in the WHO Blueprint priority diseases list. A fully registered horse anti-Hendra virus subunit vaccine has been in use in Australia since 2012. Based on the same immunogen, the Hendra virus attachment glycoprotein ectodomain, a subunit vaccine formulation for use in people is now in a Phase I clinical trial. We report that a single dose vaccination regimen of this human vaccine formulation protects against otherwise lethal challenges of either Hendra or Nipah virus in a nonhuman primate model. The protection against the Nipah Bangladesh strain begins as soon as 7 days post immunization with low dose of 0.1 mg protein subunit. Our data suggest this human vaccine could be utilized as efficient emergency vaccine to disrupt potential spreading of Nipah disease in an outbreak setting.

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GOST Copy

Geisbert T. W. et al. A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus // npj Vaccines. 2021. Vol. 6. No. 1. 23

GOST all authors (up to 50) Copy

Geisbert T. W., Bobb K., Borisevich V., Geisbert J. B., Agans K. N., Cross R. W., Prasad A. N., Fenton K. A., Yu H., Fouts T. R., Broder C. C., Dimitrov A. S. A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus // npj Vaccines. 2021. Vol. 6. No. 1. 23

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/s41541-021-00284-w

UR - https://doi.org/10.1038/s41541-021-00284-w

TI - A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus

T2 - npj Vaccines

AU - Geisbert, Thomas W.

AU - Bobb, Kathryn

AU - Borisevich, Viktoriya

AU - Geisbert, Joan B.

AU - Agans, Krystle N

AU - Cross, Robert W.

AU - Prasad, Abhishek N.

AU - Fenton, Karla A.

AU - Yu, H.

AU - Fouts, Timothy R.

AU - Broder, Christopher C.

AU - Dimitrov, Antony S

PY - 2021

DA - 2021/02/08

PB - Springer Nature

IS - 1

VL - 6

PMID - 33558494

SN - 2059-0105

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Geisbert,

author = {Thomas W. Geisbert and Kathryn Bobb and Viktoriya Borisevich and Joan B. Geisbert and Krystle N Agans and Robert W. Cross and Abhishek N. Prasad and Karla A. Fenton and H. Yu and Timothy R. Fouts and Christopher C. Broder and Antony S Dimitrov},

title = {A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus},

journal = {npj Vaccines},

year = {2021},

volume = {6},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1038/s41541-021-00284-w},

number = {1},

pages = {23},

doi = {10.1038/s41541-021-00284-w}

}

Publisher

Springer Nature

Journal

npj Vaccines

scimago Q1

wos Q1

SJR

2.236

CiteScore

11.6

Impact factor

6.5

ISSN

20590105 (Electronic)