Open Access

npj Vaccines, volume 6, issue 1, publication number 129

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Kathryn Mcguckin Wuertz ¹

Erica K Barkei ²

Wei-Hung Chen ^{3, 4}

Elizabeth J. Martinez ^{3, 4}

Ines Lakhal Naouar ^{4, 5}

Linda L. Jagodzinski ⁵

Dominic Paquin-Proulx ^{1, 4}

Gregory D. Gromowski ⁶

Isabella Swafford ^{1, 4}

Akshaya Ganesh ^{1, 7}

Ming Dong ^{1, 4}

Xiankun Zeng ⁸

Paul V. Thomas ^{3, 4}

Rajeshwer S. Sankhala ^{3, 4}

Agnes Hajduczki ^{3, 4}

Caroline E. Peterson ^{3, 4}

Caitlin Kuklis ⁶

Sandrine Soman ⁶

Lindsay Wieczorek ^{1, 4}

Michelle Zemil ^{1, 4}

Alexander Anderson ^{3, 7}

Janice Darden ^{4, 5}

Heather Hernandez ^{4, 5}

Hannah Grove ^{4, 5}

Vincent Dussupt ^{1, 4}

Holly Hack ^{4, 5}

Rafael De La Barrera ⁹

Stasya Zarling ⁹

James F Wood ⁹

Jeffrey W Froude ⁹

Matthew Gagné ¹⁰

Amy R. Henry ¹⁰

Elham Bayat Mokhtari ¹¹

Prakriti Mudvari ¹¹

Shelly J. Krebs ^{1, 4}

Andrew Pekosz ¹²

Jeffrey R. Currier ⁶

SWAGATA KAR ¹³

Maciel Porto ¹³

Adrienne Winn ¹³

Kamil Radzyminski ¹³

Mark G. Lewis ¹³

Sandhya Vasan ⁴

Mehul Suthar ¹⁴

Victoria R Polonis ¹

Gary R Matyas ¹

Eli A Boritz ¹¹

Daniel C. Douek ¹⁰

Robert A. Seder ¹⁵

Sharon P Daye ¹⁶

Mangala Rao ¹

Sheila A. Peel ⁵

M. Gordon Joyce ^{3, 4}

Diane L. Bolton ^{1, 4}

Nelson Michael ¹⁷

Kayvon Modjarrad ³

Show full list: 56 authors

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U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, USA |

Veterinary Pathology Division, Walter Reed Army Institute of Research, Silver Spring, USA |

Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, USA |

⁴

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, USA |

⁵

Diagnostics Countermeasures Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, USA |

⁶

Virus Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, USA |

⁷

Oak Ridge Institute of Science and Education, Oak Ridge, USA |

⁸

Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, USA |

⁹

Pilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, USA |

¹⁰

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and infectious Diseases, National Institutes of Health, Bethesda, USA |

¹¹

Virus Persistence and Dynamics Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA |

¹²

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA |

¹³

Bioqual, Inc., Rockville, USA |

¹⁴

Emory Vaccine Center, Department of Pediatrics, Emory School of Medicine, Atlanta, USA |

¹⁵

Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA |

¹⁶

One Health Branch, Walter Reed Army Institute of Research, Silver Spring, USA |

¹⁷

Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, USA |

Publication type: Journal Article

Publication date: 2021-10-28

Springer Nature

Journal: npj Vaccines

scimago Q1

SJR: 2.127

CiteScore: 11.9

Impact factor: 6.9

ISSN: 20590105

DOI: 10.1038/s41541-021-00392-7

Copy DOI

Pharmacology

Infectious Diseases

Pharmacology (medical)

Immunology

Abstract

The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the Alpha (B.1.1.7), and Beta (B.1.351) VOCs in Syrian golden hamsters. SpFN-ALFQ was administered as either single or double-vaccination (0 and 4 week) regimens, using a high (10 μg) or low (0.2 μg) dose. Animals were intranasally challenged at week 11. Binding antibody responses were comparable between high- and low-dose groups. Neutralizing antibody titers were equivalent against WA1, B.1.1.7, and B.1.351 variants following two high dose vaccinations. Dose-dependent SpFN-ALFQ vaccination protected against SARS-CoV-2-induced disease and viral replication following intranasal B.1.1.7 or B.1.351 challenge, as evidenced by reduced weight loss, lung pathology, and lung and nasal turbinate viral burden. These data support the development of SpFN-ALFQ as a broadly protective, next-generation SARS-CoV-2 vaccine.

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TY - JOUR

DO - 10.1038/s41541-021-00392-7

UR - https://doi.org/10.1038/s41541-021-00392-7

TI - A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

T2 - npj Vaccines

AU - Wuertz, Kathryn Mcguckin

AU - Barkei, Erica K

AU - Chen, Wei-Hung

AU - Martinez, Elizabeth J.

AU - Lakhal Naouar, Ines

AU - Jagodzinski, Linda L.

AU - Paquin-Proulx, Dominic

AU - Gromowski, Gregory D.

AU - Swafford, Isabella

AU - Ganesh, Akshaya

AU - Dong, Ming

AU - Zeng, Xiankun

AU - Thomas, Paul V.

AU - Sankhala, Rajeshwer S.

AU - Hajduczki, Agnes

AU - Peterson, Caroline E.

AU - Kuklis, Caitlin

AU - Soman, Sandrine

AU - Wieczorek, Lindsay

AU - Zemil, Michelle

AU - Anderson, Alexander

AU - Darden, Janice

AU - Hernandez, Heather

AU - Grove, Hannah

AU - Dussupt, Vincent

AU - Hack, Holly

AU - De La Barrera, Rafael

AU - Zarling, Stasya

AU - Wood, James F

AU - Froude, Jeffrey W

AU - Gagné, Matthew

AU - Henry, Amy R.

AU - Mokhtari, Elham Bayat

AU - Mudvari, Prakriti

AU - Krebs, Shelly J.

AU - Pekosz, Andrew

AU - Currier, Jeffrey R.

AU - KAR, SWAGATA

AU - Porto, Maciel

AU - Winn, Adrienne

AU - Radzyminski, Kamil

AU - Lewis, Mark G.

AU - Vasan, Sandhya

AU - Suthar, Mehul

AU - Polonis, Victoria R

AU - Matyas, Gary R

AU - Boritz, Eli A

AU - Douek, Daniel C.

AU - Seder, Robert A.

AU - Daye, Sharon P

AU - Rao, Mangala

AU - Peel, Sheila A.

AU - Gordon Joyce, M.

AU - Bolton, Diane L.

AU - Michael, Nelson

AU - Modjarrad, Kayvon

PY - 2021

DA - 2021/10/28

PB - Springer Nature

IS - 1

VL - 6

SN - 2059-0105

ER -

BibTex

Found error?

Publisher

Springer Nature

Journal

npj Vaccines

scimago Q1

SJR

2.127

CiteScore

11.9

Impact factor

6.9

ISSN

20590105 (Electronic)

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

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