Nature Biomedical Engineering

, volume 7 , issue 4

Bioengineering strategies for restoring vision

Jasmina Cehajic-Kapetanovic ^{1, 2}

Mandeep S. Singh ³

Eberhart Zrenner ⁴

Robert MacLaren ^{1, 2}

Hide authors affiliations Show authors affiliations: 4 affiliations

Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, UK |

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK |

Johns Hopkins Medical Institute, Baltimore, USA |

⁴

Institute for Ophthalmic Research, Center for Ophthalmology, University of Tübingen, Tübingen, Germany |

Publication type: Journal Article

Publication date: 2022-01-31

Springer Nature

Nature Biomedical Engineering

scimago Q1

wos Q1

SJR: 10.105

CiteScore: 49.0

Impact factor: 26.6

ISSN: 2157846X

DOI: 10.1038/s41551-021-00836-4

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PubMed ID: 35102278

Medicine (miscellaneous)

Computer Science Applications

Biotechnology

Bioengineering

Biomedical Engineering

Abstract

Late-stage retinal degenerative disease involving photoreceptor loss can be treated by optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to restore light sensitivity to the retina as well as visual perception by integrating neuronal responses for transmission to the cortex. In age-related macular degeneration, some cell-based therapies also aim to restore photoreceptor-supporting tissue to prevent complete photoreceptor loss. In the earlier stages of degeneration, gene-replacement therapy could attenuate retinal-disease progression and reverse loss of function. And gene-editing strategies aim to correct the underlying genetic defects. In this Review, we highlight the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal disease, discuss the benefits and drawbacks of each treatment strategy and the factors influencing whether functional tissue is reconstructed and repaired or replaced with an electronic device, and summarize upcoming technologies for enhancing the restoration of vision. This Review discusses the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal degeneration, as well as upcoming technologies for enhancing vision restoration.

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Cehajic-Kapetanovic J. et al. Bioengineering strategies for restoring vision // Nature Biomedical Engineering. 2022. Vol. 7. No. 4.

GOST all authors (up to 50) Copy

Cehajic-Kapetanovic J., Singh M. S., Zrenner E., MacLaren R. Bioengineering strategies for restoring vision // Nature Biomedical Engineering. 2022. Vol. 7. No. 4.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41551-021-00836-4

UR - https://doi.org/10.1038/s41551-021-00836-4

TI - Bioengineering strategies for restoring vision

T2 - Nature Biomedical Engineering

AU - Cehajic-Kapetanovic, Jasmina

AU - Singh, Mandeep S.

AU - Zrenner, Eberhart

AU - MacLaren, Robert

PY - 2022

DA - 2022/01/31

PB - Springer Nature

IS - 4

VL - 7

PMID - 35102278

SN - 2157-846X

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Cehajic-Kapetanovic,

author = {Jasmina Cehajic-Kapetanovic and Mandeep S. Singh and Eberhart Zrenner and Robert MacLaren},

title = {Bioengineering strategies for restoring vision},

journal = {Nature Biomedical Engineering},

year = {2022},

volume = {7},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038/s41551-021-00836-4},

number = {4},

doi = {10.1038/s41551-021-00836-4}

}

Publisher

Springer Nature

Journal

Nature Biomedical Engineering

scimago Q1

wos Q1

SJR

10.105

CiteScore

49.0

Impact factor

26.6

ISSN

2157846X (Electronic)