Nature Cell Biology, volume 23, issue 4, pages 305-313

R-loops as Janus-faced modulators of DNA repair

Aline Marnef ¹

Gaëlle Legube ¹

Molecular, Cellular and Developmental Biology Department (MCD), Centre de Biologie Integrative (CBI), University of Toulouse, CNRS, UPS, Toulouse, France |

Publication type: Journal Article

Publication date: 2021-04-09

Springer Nature

Journal: Nature Cell Biology

scimago Q1

wos Q1

SJR: 8.913

CiteScore: 28.4

Impact factor: 17.3

ISSN: 14657392, 14764679

DOI: 10.1038/s41556-021-00663-4

Copy DOI

Cell Biology

Abstract

R-loops are non-B DNA structures with intriguing dual consequences for gene expression and genome stability. In addition to their recognized roles in triggering DNA double-strand breaks (DSBs), R-loops have recently been demonstrated to accumulate in cis to DSBs, especially those induced in transcriptionally active loci. In this Review, we discuss whether R-loops actively participate in DSB repair or are detrimental by-products that must be removed to avoid genome instability. Legube and Marnef review the association between R-loops and DNA repair. They discuss how R-loops are formed near DNA double-strand breaks (DSBs) and how R-loops affect transcription near DSBs and DSB repair processes.

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