Nature Human Behaviour

, volume 5 , issue 12 , pages 1744-1758

Resource profile and user guide of the Polygenic Index Repository

Joel Becker ¹

Casper A P Burik ²

Grant Goldman ³

Nancy Wang ³

Hariharan Jayashankar ³

Michael Bennett ³

Daniel W. Belsky ^{4, 5}

Robert Karlsson ²

Rafael Ahlskog ⁶

Aaron Kleinman ⁷

David A. Hinds ⁷

Michelle Agee ^{8, 9, 10, 11}

BABAK ALIPANAHI ¹⁰

Adam Auton ^{8, 9, 10, 11}

Robert K. Bell ¹²

Katarzyna Bryc ⁸

Sarah L. Elson ⁸

Pierre Fontanillas ^{13, 14}

Nicholas A Furlotte ¹⁵

Karen E. Huber ^{15, 16}

Nadia K. Litterman ¹⁷

Jennifer C. McCreight ^{17, 18}

Matthew H. McIntyre ¹⁹

Joanna L. Mountain ¹⁹

Carrie A. M. Northover ²⁰

Steven J. Pitts ²¹

J. Fah Sathirapongsasuti ^{21, 22}

Olga V Sazonova ^{21, 22}

Janie F. Shelton ²³

Suyash Shringarpure ²⁴

Chao Tian ^{25, 26}

Joyce Y. Tung ²⁷

Vladimir Vacic ^{2, 28}

Catherine H. Wilson ⁶

Avshalom Caspi ²⁹

David L. Corcoran ³⁰

Terrie E. Moffitt ³¹

Richie Poulton ^{3, 32}

Karen Sugden ^{1, 3}

Benjamin S. Williams ^{3, 25, 26}

Kathleen Mullan Harris ^{33, 34}

Andrew Steptoe ²

Hide authors affiliations Show authors affiliations: 34 affiliations

Department of Economics, New York University, New York, USA |

Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands |

National Bureau of Economic Research, Cambridge, USA |

⁴

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, USA |

⁵

Robert N. Butler Columbia Aging Center, Columbia University, New York, USA |

⁶

Department of Government, Uppsala university, Uppsala, Sweden |

⁷

23andMe, Inc., Mountain View, USA |

⁸

Department of Psychology and Neuroscience, Duke University, Durham, USA |

⁹

Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK |

¹⁰

Center for Genomic and Computational Biology, Duke University, Durham, USA |

¹¹

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, USA |

¹²

Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand |

¹³

Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, USA |

¹⁴

Carolina Population Center, University of North Carolina At Chapel Hill, Chapel Hill, USA |

¹⁵

Department of Behavioural Science and Health, University College London, London, UK |

¹⁶

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, London, UK |

¹⁷

Institute of Genomics, University of Tartu, Tartu, Estonia |

¹⁸

Broad Institute of MIT and Harvard, Cambridge, USA |

¹⁹

Department of Psychology, University of Minnesota, Minneapolis, USA |

²⁰

Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden |

²¹

Department of Psychology, The University of Texas At Austin, Austin, USA |

²²

Population research Center, The University of Texas at Austin, Austin, USA |

²³

McCourt School of Public Policy, Georgetown University, Washington, USA |

²⁴

Department of Sociology, Stanford University, Stanford, USA |

²⁵

UCLA Anderson School of Management, Los Angeles, USA |

²⁶

Human Genetics Department, UCLA David Geffen School of Medicine, Los Angeles, USA |

²⁷

Interdisciplinary Center for Economic Science and Department of Economics, George Mason University, Fairfax, USA |

²⁸

Robert M. La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, USA |

²⁹

Department of Economics, Stockholm School of Economics, Stockholm, SWEDEN |

³⁰

Institute for Molecular Bioscience, the University of Queensland, Brisbane, Australia |

³¹

Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, USA |

³²

Department of Economics, Harvard University, Cambridge, USA |

³³

Center for Economic and Social Research, University of Southern California, Los Angeles, USA |

³⁴

Department of Economics, University of Southern California, Los Angeles, USA |

Publication type: Journal Article

Publication date: 2021-06-17

Springer Nature

Nature Human Behaviour

scimago Q1

wos Q1

SJR: 5.537

CiteScore: 31.0

Impact factor: 15.9

ISSN: 23973374

DOI: 10.1038/s41562-021-01119-3

Copy DOI

PubMed ID: 34140656

Experimental and Cognitive Psychology

Behavioral Neuroscience

Social Psychology

Abstract

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the PGIs’ prediction accuracies, we constructed them using genome-wide association studies—some not previously published—from multiple data sources, including 23andMe and UK Biobank. We present a theoretical framework to help interpret analyses involving PGIs. A key insight is that a PGI can be understood as an unbiased but noisy measure of a latent variable we call the ‘additive SNP factor’. Regressions in which the true regressor is this factor but the PGI is used as its proxy therefore suffer from errors-in-variables bias. We derive an estimator that corrects for the bias, illustrate the correction, and make a Python tool for implementing it publicly available. Benjamin et al. construct polygenic indexes (DNA-based predictors) for 47 phenotypes and make them available to researchers in 11 datasets. They also present a theoretical framework and estimator to help interpret analyses using polygenic indexes.

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GOST Copy

Becker J. et al. Resource profile and user guide of the Polygenic Index Repository // Nature Human Behaviour. 2021. Vol. 5. No. 12. pp. 1744-1758.

GOST all authors (up to 50) Copy

Becker J. et al. Resource profile and user guide of the Polygenic Index Repository // Nature Human Behaviour. 2021. Vol. 5. No. 12. pp. 1744-1758.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41562-021-01119-3

UR - https://doi.org/10.1038/s41562-021-01119-3

TI - Resource profile and user guide of the Polygenic Index Repository

T2 - Nature Human Behaviour

AU - Becker, Joel

AU - Burik, Casper A P

AU - Goldman, Grant

AU - Wang, Nancy

AU - Jayashankar, Hariharan

AU - Bennett, Michael

AU - Belsky, Daniel W.

AU - Karlsson, Robert

AU - Ahlskog, Rafael

AU - Kleinman, Aaron

AU - Hinds, David A.

AU - Agee, Michelle

AU - ALIPANAHI, BABAK

AU - Auton, Adam

AU - Bell, Robert K.

AU - Bryc, Katarzyna

AU - Elson, Sarah L.

AU - Fontanillas, Pierre

AU - Furlotte, Nicholas A

AU - Huber, Karen E.

AU - Litterman, Nadia K.

AU - McCreight, Jennifer C.

AU - McIntyre, Matthew H.

AU - Mountain, Joanna L.

AU - Northover, Carrie A. M.

AU - Pitts, Steven J.

AU - Sathirapongsasuti, J. Fah

AU - Sazonova, Olga V

AU - Shelton, Janie F.

AU - Shringarpure, Suyash

AU - Tian, Chao

AU - Tung, Joyce Y.

AU - Vacic, Vladimir

AU - Wilson, Catherine H.

AU - Caspi, Avshalom

AU - Corcoran, David L.

AU - Moffitt, Terrie E.

AU - Poulton, Richie

AU - Sugden, Karen

AU - Williams, Benjamin S.

AU - Harris, Kathleen Mullan

AU - Steptoe, Andrew

PY - 2021

DA - 2021/06/17

PB - Springer Nature

SP - 1744-1758

IS - 12

VL - 5

PMID - 34140656

SN - 2397-3374

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Becker,

author = {Joel Becker and Casper A P Burik and Grant Goldman and Nancy Wang and Hariharan Jayashankar and Michael Bennett and Daniel W. Belsky and Robert Karlsson and Rafael Ahlskog and Aaron Kleinman and David A. Hinds and Michelle Agee and BABAK ALIPANAHI and Adam Auton and Robert K. Bell and Katarzyna Bryc and Sarah L. Elson and Pierre Fontanillas and Nicholas A Furlotte and Karen E. Huber and Nadia K. Litterman and Jennifer C. McCreight and Matthew H. McIntyre and Joanna L. Mountain and Carrie A. M. Northover and Steven J. Pitts and J. Fah Sathirapongsasuti and Olga V Sazonova and Janie F. Shelton and Suyash Shringarpure and Chao Tian and Joyce Y. Tung and Vladimir Vacic and Catherine H. Wilson and Avshalom Caspi and David L. Corcoran and Terrie E. Moffitt and Richie Poulton and Karen Sugden and Benjamin S. Williams and Kathleen Mullan Harris and Andrew Steptoe and others},

title = {Resource profile and user guide of the Polygenic Index Repository},

journal = {Nature Human Behaviour},

year = {2021},

volume = {5},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1038/s41562-021-01119-3},

number = {12},

pages = {1744--1758},

doi = {10.1038/s41562-021-01119-3}

}

MLA

Cite this

MLA Copy

Becker, Joel, et al. “Resource profile and user guide of the Polygenic Index Repository.” Nature Human Behaviour, vol. 5, no. 12, Jun. 2021, pp. 1744-1758. https://doi.org/10.1038/s41562-021-01119-3.

Publisher

Springer Nature

Journal

Nature Human Behaviour

scimago Q1

wos Q1

SJR

5.537

CiteScore

31.0

Impact factor

15.9

ISSN

23973374 (Electronic)