Pancreatic cystic neoplasms (PCN) are a heterogeneous group of pancreatic cysts that include intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, serous cystic neoplasms and other rare cystic lesions, all with different biological behaviours and variable risk of progression to malignancy. As more pancreatic cysts are incidentally discovered on routine cross-sectional imaging, optimal surveillance for patients with PCN is becoming an increasingly common clinical problem, highlighting the need to balance cancer prevention with the risk of (surgical) overtreatment. This Review summarizes the latest developments in the diagnosis and management of PCN, including the quality of available evidence. Also discussed are the most important differences between the PCN guidelines from the American Gastroenterological Association, the International Association of Pancreatology and the European Study Group on Cystic Tumours of the Pancreas, including diagnostic and follow-up strategies and indications for surgery. Finally, new developments in the management of patients with PCN are addressed. Pancreatic cystic neoplasms are a heterogeneous group of pancreatic cysts with different biological behaviours and variable risk of progression to malignancy. This Review summarizes the latest developments in the diagnosis and management of pancreatic cysts, including the quality of available evidence.

Found

1 citation

Piemonti Lorenzo

373 publications, 20 495 citations, 157 reviews

h-index: 71

Vita-Salute San Raffaele University

Ospedale San Raffaele

Research interests

Diabetes

Regenerative medicine

Top-30

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Cancers	Cancers, 9, 4.52% Cancers 9 publications, 4.52%
Frontiers in Oncology	Frontiers in Oncology, 6, 3.02% Frontiers in Oncology 6 publications, 3.02%
Journal of Clinical Medicine	Journal of Clinical Medicine, 5, 2.51% Journal of Clinical Medicine 5 publications, 2.51%
Diagnostics	Diagnostics, 5, 2.51% Diagnostics 5 publications, 2.51%
Academic Radiology	Academic Radiology, 5, 2.51% Academic Radiology 5 publications, 2.51%
Pancreas	Pancreas, 4, 2.01% Pancreas 4 publications, 2.01%
World Journal of Gastrointestinal Oncology	World Journal of Gastrointestinal Oncology, 4, 2.01% World Journal of Gastrointestinal Oncology 4 publications, 2.01%
Quantitative Imaging in Medicine and Surgery	Quantitative Imaging in Medicine and Surgery, 4, 2.01% Quantitative Imaging in Medicine and Surgery 4 publications, 2.01%
Abdominal Radiology	Abdominal Radiology, 3, 1.51% Abdominal Radiology 3 publications, 1.51%
Pancreatology	Pancreatology, 3, 1.51% Pancreatology 3 publications, 1.51%
Cureus	Cureus, 3, 1.51% Cureus 3 publications, 1.51%
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American Journal of Gastroenterology	American Journal of Gastroenterology, 2, 1.01% American Journal of Gastroenterology 2 publications, 1.01%
Medicine (United States)	Medicine (United States), 2, 1.01% Medicine (United States) 2 publications, 1.01%
Langenbeck's Archives of Surgery	Langenbeck's Archives of Surgery, 2, 1.01% Langenbeck's Archives of Surgery 2 publications, 1.01%
Schweizer Gastroenterologie	Schweizer Gastroenterologie, 2, 1.01% Schweizer Gastroenterologie 2 publications, 1.01%
Scientific Reports	Scientific Reports, 2, 1.01% Scientific Reports 2 publications, 1.01%
Gastrointestinal Endoscopy	Gastrointestinal Endoscopy, 2, 1.01% Gastrointestinal Endoscopy 2 publications, 1.01%
Asian Journal of Surgery	Asian Journal of Surgery, 2, 1.01% Asian Journal of Surgery 2 publications, 1.01%
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Cancer Letters	Cancer Letters, 2, 1.01% Cancer Letters 2 publications, 1.01%
Cancer Management and Research	Cancer Management and Research, 2, 1.01% Cancer Management and Research 2 publications, 1.01%
Gut	Gut, 2, 1.01% Gut 2 publications, 1.01%
World Journal of Surgical Oncology	World Journal of Surgical Oncology, 2, 1.01% World Journal of Surgical Oncology 2 publications, 1.01%
Annals of Surgical Oncology	Annals of Surgical Oncology, 2, 1.01% Annals of Surgical Oncology 2 publications, 1.01%
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Elsevier	Elsevier, 41, 20.6% Elsevier 41 publications, 20.6%
Springer Nature	Springer Nature, 35, 17.59% Springer Nature 35 publications, 17.59%
MDPI	MDPI, 24, 12.06% MDPI 24 publications, 12.06%
Wiley	Wiley, 17, 8.54% Wiley 17 publications, 8.54%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 14, 7.04% Ovid Technologies (Wolters Kluwer Health) 14 publications, 7.04%
Frontiers Media S.A.	Frontiers Media S.A., 10, 5.03% Frontiers Media S.A. 10 publications, 5.03%
Taylor & Francis	Taylor & Francis, 8, 4.02% Taylor & Francis 8 publications, 4.02%
Baishideng Publishing Group	Baishideng Publishing Group, 6, 3.02% Baishideng Publishing Group 6 publications, 3.02%
AME Publishing Company	AME Publishing Company, 6, 3.02% AME Publishing Company 6 publications, 3.02%
BMJ	BMJ, 3, 1.51% BMJ 3 publications, 1.51%
Radiological Society of North America (RSNA)	Radiological Society of North America (RSNA), 2, 1.01% Radiological Society of North America (RSNA) 2 publications, 1.01%
SAGE	SAGE, 2, 1.01% SAGE 2 publications, 1.01%
Oxford University Press	Oxford University Press, 2, 1.01% Oxford University Press 2 publications, 1.01%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 2, 1.01% Georg Thieme Verlag KG 2 publications, 1.01%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 2, 1.01% American Association for Cancer Research (AACR) 2 publications, 1.01%
Obsidiana Editores	Obsidiana Editores, 1, 0.5% Obsidiana Editores 1 publication, 0.5%
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American Medical Association (AMA)	American Medical Association (AMA), 1, 0.5% American Medical Association (AMA) 1 publication, 0.5%
The Korean Society of Gastrointestinal Endoscopy	The Korean Society of Gastrointestinal Endoscopy, 1, 0.5% The Korean Society of Gastrointestinal Endoscopy 1 publication, 0.5%
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SciELO	SciELO, 1, 0.5% SciELO 1 publication, 0.5%
Research Square Platform LLC	Research Square Platform LLC, 1, 0.5% Research Square Platform LLC 1 publication, 0.5%
The Korean Society for Transplantation	The Korean Society for Transplantation, 1, 0.5% The Korean Society for Transplantation 1 publication, 0.5%
Hans Publishers	Hans Publishers, 1, 0.5% Hans Publishers 1 publication, 0.5%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 1, 0.5% American Society of Clinical Oncology (ASCO) 1 publication, 0.5%
Media Sphere Publishing House	Media Sphere Publishing House, 1, 0.5% Media Sphere Publishing House 1 publication, 0.5%
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Annals of Surgical Hepatology	Annals of Surgical Hepatology, 1, 0.5% Annals of Surgical Hepatology 1 publication, 0.5%
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199

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GOST |

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GOST Copy

van Huijgevoort N. C. et al. Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines // Nature Reviews Gastroenterology and Hepatology. 2019. Vol. 16. No. 11. pp. 676-689.

GOST all authors (up to 50) Copy

van Huijgevoort N. C., Del Chiaro M., Wolfgang C. L., van Hooft J. E., Besselink M. G. Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines // Nature Reviews Gastroenterology and Hepatology. 2019. Vol. 16. No. 11. pp. 676-689.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/s41575-019-0195-x

UR - https://doi.org/10.1038/s41575-019-0195-x

TI - Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines

T2 - Nature Reviews Gastroenterology and Hepatology

AU - van Huijgevoort, Nadine C.M.

AU - Del Chiaro, Marco

AU - Wolfgang, Christopher L.

AU - van Hooft, Jeanin E.

AU - Besselink, Marc G

PY - 2019

DA - 2019/09/16

PB - Springer Nature

SP - 676-689

IS - 11

VL - 16

PMID - 31527862

SN - 1759-5045

SN - 1759-5053

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_van Huijgevoort,

author = {Nadine C.M. van Huijgevoort and Marco Del Chiaro and Christopher L. Wolfgang and Jeanin E. van Hooft and Marc G Besselink},

title = {Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines},

journal = {Nature Reviews Gastroenterology and Hepatology},

year = {2019},

volume = {16},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1038/s41575-019-0195-x},

number = {11},

pages = {676--689},

doi = {10.1038/s41575-019-0195-x}

}

MLA

Cite this

MLA Copy

van Huijgevoort, Nadine C.M., et al. “Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines.” Nature Reviews Gastroenterology and Hepatology, vol. 16, no. 11, Sep. 2019, pp. 676-689. https://doi.org/10.1038/s41575-019-0195-x.

Publisher

Springer Nature

Journal

Nature Reviews Gastroenterology and Hepatology

scimago Q1

wos Q1

SJR

9.911

CiteScore

58.7

Impact factor

51.0

ISSN

17595045 (Print)

17595053 (Electronic)