Guidelines and definitions for research on epithelial–mesenchymal transition
Jing Yang
1
,
Parker Antin
2
,
Geert Berx
3
,
Cédric Blanpain
4
,
Thomas Brabletz
5
,
Marianne Bronner
6
,
Kyra Campbell
7
,
Amparo Cano
8
,
Jordi Casanova
9
,
Gerhard Christofori
10
,
Shoukat Dedhar
11
,
Rik Derynck
12
,
Heide L Ford
13
,
Jonas Fuxe
14
,
Antonio García de Herreros
15
,
Gregory J. Goodall
16
,
Anna-Katerina Hadjantonakis
17
,
Ruby Y J Huang
18
,
Chaya Kalcheim
19
,
Raghu Kalluri
20
,
Yibin Kang
21
,
Yeesim Khew-Goodall
22
,
Herbert Levine
23
,
Jinsong Liu
24
,
Gregory D. Longmore
25
,
Sendurai A Mani
26
,
Joan Massagué
27
,
R. F. Mayor
28
,
David McClay
29
,
Keith Mostov
30
,
Donald Newgreen
31
,
M. M. Nieto
32
,
Alain Puisieux
33, 34
,
Ray Runyan
2
,
PIERRE SAVAGNER
35
,
Ben Stanger
36
,
Marc P. Stemmler
5
,
Yoshiko Takahashi
37
,
M. Takeichi
38
,
Eric Theveneau
39
,
Jean-Paul Thiery
40
,
Erik W. Thompson
41
,
Robert A. Weinberg
42
,
Elizabeth C. Williams
43
,
Jianhua Xing
44
,
Binhua P. Zhou
45
,
Guojun Sheng
46
3
6
14
15
19
20
31
33
34
35
36
40
Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China
|
41
42
Publication type: Journal Article
Publication date: 2020-04-16
scimago Q1
wos Q1
SJR: 37.353
CiteScore: 150.9
Impact factor: 90.2
ISSN: 14710072, 14710080
PubMed ID:
32300252
Molecular Biology
Cell Biology
Abstract
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
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GOST
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Yang J. et al. Guidelines and definitions for research on epithelial–mesenchymal transition // Nature Reviews Molecular Cell Biology. 2020. Vol. 21. No. 6. pp. 341-352.
GOST all authors (up to 50)
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Yang J., Antin P., Berx G., Blanpain C., Brabletz T., Bronner M., Campbell K., Cano A., Casanova J., Christofori G., Dedhar S., Derynck R., Ford H. L., Fuxe J., García de Herreros A., Goodall G. J., Hadjantonakis A., Huang R. Y. J., Kalcheim C., Kalluri R., Kang Y., Khew-Goodall Y., Levine H., Liu J., Longmore G. D., Mani S. A., Massagué J., Mayor R. F., McClay D., Mostov K., Newgreen D., Nieto M. M., Puisieux A., Runyan R., SAVAGNER P., Stanger B., Stemmler M. P., Takahashi Y., Takeichi M., Theveneau E., Thiery J., Thompson E. W., Weinberg R. A., Williams E. C., Xing J., Zhou B. P., Sheng G. Guidelines and definitions for research on epithelial–mesenchymal transition // Nature Reviews Molecular Cell Biology. 2020. Vol. 21. No. 6. pp. 341-352.
Cite this
RIS
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TY - JOUR
DO - 10.1038/s41580-020-0237-9
UR - https://www.nature.com/articles/s41580-020-0237-9
TI - Guidelines and definitions for research on epithelial–mesenchymal transition
T2 - Nature Reviews Molecular Cell Biology
AU - Yang, Jing
AU - Antin, Parker
AU - Berx, Geert
AU - Blanpain, Cédric
AU - Brabletz, Thomas
AU - Bronner, Marianne
AU - Campbell, Kyra
AU - Cano, Amparo
AU - Casanova, Jordi
AU - Christofori, Gerhard
AU - Dedhar, Shoukat
AU - Derynck, Rik
AU - Ford, Heide L
AU - Fuxe, Jonas
AU - García de Herreros, Antonio
AU - Goodall, Gregory J.
AU - Hadjantonakis, Anna-Katerina
AU - Huang, Ruby Y J
AU - Kalcheim, Chaya
AU - Kalluri, Raghu
AU - Kang, Yibin
AU - Khew-Goodall, Yeesim
AU - Levine, Herbert
AU - Liu, Jinsong
AU - Longmore, Gregory D.
AU - Mani, Sendurai A
AU - Massagué, Joan
AU - Mayor, R. F.
AU - McClay, David
AU - Mostov, Keith
AU - Newgreen, Donald
AU - Nieto, M. M.
AU - Puisieux, Alain
AU - Runyan, Ray
AU - SAVAGNER, PIERRE
AU - Stanger, Ben
AU - Stemmler, Marc P.
AU - Takahashi, Yoshiko
AU - Takeichi, M.
AU - Theveneau, Eric
AU - Thiery, Jean-Paul
AU - Thompson, Erik W.
AU - Weinberg, Robert A.
AU - Williams, Elizabeth C.
AU - Xing, Jianhua
AU - Zhou, Binhua P.
AU - Sheng, Guojun
PY - 2020
DA - 2020/04/16
PB - Springer Nature
SP - 341-352
IS - 6
VL - 21
PMID - 32300252
SN - 1471-0072
SN - 1471-0080
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Yang,
author = {Jing Yang and Parker Antin and Geert Berx and Cédric Blanpain and Thomas Brabletz and Marianne Bronner and Kyra Campbell and Amparo Cano and Jordi Casanova and Gerhard Christofori and Shoukat Dedhar and Rik Derynck and Heide L Ford and Jonas Fuxe and Antonio García de Herreros and Gregory J. Goodall and Anna-Katerina Hadjantonakis and Ruby Y J Huang and Chaya Kalcheim and Raghu Kalluri and Yibin Kang and Yeesim Khew-Goodall and Herbert Levine and Jinsong Liu and Gregory D. Longmore and Sendurai A Mani and Joan Massagué and R. F. Mayor and David McClay and Keith Mostov and Donald Newgreen and M. M. Nieto and Alain Puisieux and Ray Runyan and PIERRE SAVAGNER and Ben Stanger and Marc P. Stemmler and Yoshiko Takahashi and M. Takeichi and Eric Theveneau and Jean-Paul Thiery and Erik W. Thompson and Robert A. Weinberg and Elizabeth C. Williams and Jianhua Xing and Binhua P. Zhou and Guojun Sheng},
title = {Guidelines and definitions for research on epithelial–mesenchymal transition},
journal = {Nature Reviews Molecular Cell Biology},
year = {2020},
volume = {21},
publisher = {Springer Nature},
month = {apr},
url = {https://www.nature.com/articles/s41580-020-0237-9},
number = {6},
pages = {341--352},
doi = {10.1038/s41580-020-0237-9}
}
Cite this
MLA
Copy
Yang, Jing, et al. “Guidelines and definitions for research on epithelial–mesenchymal transition.” Nature Reviews Molecular Cell Biology, vol. 21, no. 6, Apr. 2020, pp. 341-352. https://www.nature.com/articles/s41580-020-0237-9.
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