CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Publication type: Journal Article
Publication date: 2022-09-02
scimago Q1
wos Q1
SJR: 9.331
CiteScore: 34.9
Impact factor: 26.7
ISSN: 1471003X, 14710048
PubMed ID:
36056211
General Neuroscience
Abstract
Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is activated by intracellular increases in calcium ion levels and triggers molecular processes necessary for synaptic plasticity. CaMKII phosphorylates numerous synaptic proteins, thereby regulating their structure and functions. This leads to molecular events crucial for synaptic plasticity, such as receptor trafficking, localization and activity; actin cytoskeletal dynamics; translation; and even transcription through synapse–nucleus shuttling. Several new tools affording increasingly greater spatiotemporal resolution have revealed the link between CaMKII activity and downstream signalling processes in dendritic spines during synaptic and behavioural plasticity. These technologies have provided insights into the function of CaMKII in learning and memory. Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) has a central role in synaptic plasticity, learning and memory. In this Review, Yasuda, Hayashi and Hell provide an overview of the postsynaptic regulation and function of CaMKII.
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Metrics
331
Total citations:
331
Citations from 2024:
266
(80.36%)
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Yasuda R., Hayashi Y., Hell J. W. CaMKII: a central molecular organizer of synaptic plasticity, learning and memory // Nature Reviews Neuroscience. 2022. Vol. 23. No. 11. pp. 666-682.
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Yasuda R., Hayashi Y., Hell J. W. CaMKII: a central molecular organizer of synaptic plasticity, learning and memory // Nature Reviews Neuroscience. 2022. Vol. 23. No. 11. pp. 666-682.
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TY - JOUR
DO - 10.1038/s41583-022-00624-2
UR - https://doi.org/10.1038/s41583-022-00624-2
TI - CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
T2 - Nature Reviews Neuroscience
AU - Yasuda, Ryohei
AU - Hayashi, Yasunori
AU - Hell, Johannes W.
PY - 2022
DA - 2022/09/02
PB - Springer Nature
SP - 666-682
IS - 11
VL - 23
PMID - 36056211
SN - 1471-003X
SN - 1471-0048
ER -
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BibTex (up to 50 authors)
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@article{2022_Yasuda,
author = {Ryohei Yasuda and Yasunori Hayashi and Johannes W. Hell},
title = {CaMKII: a central molecular organizer of synaptic plasticity, learning and memory},
journal = {Nature Reviews Neuroscience},
year = {2022},
volume = {23},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1038/s41583-022-00624-2},
number = {11},
pages = {666--682},
doi = {10.1038/s41583-022-00624-2}
}
Cite this
MLA
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Yasuda, Ryohei, et al. “CaMKII: a central molecular organizer of synaptic plasticity, learning and memory.” Nature Reviews Neuroscience, vol. 23, no. 11, Sep. 2022, pp. 666-682. https://doi.org/10.1038/s41583-022-00624-2.