Detection of a SARS-CoV-2 variant of concern in South Africa
Houriiyah Tegally
1
,
Eduan Wilkinson
1
,
Marta Giovanetti
2, 3
,
Arash Iranzadeh
4
,
Vagner Fonseca
1, 3
,
Jennifer Giandhari
1
,
Deelan Doolabh
5
,
Sureshnee Pillay
1
,
Emmanuel James San
1
,
Nokukhanya Msomi
6
,
Koleka Mlisana
7, 8
,
Anne von Gottberg
9, 10
,
Sibongile Walaza
9, 11
,
Mushal Allam
9
,
Arshad Ismail
9
,
Thabo Mohale
9
,
Allison J Glass
10, 12
,
Susan Engelbrecht
13
,
Gert van Zyl
13
,
Wolfgang Preiser
13
,
Francesco Petruccione
14, 15
,
Alex Sigal
16, 17, 18
,
Diana Hardie
19
,
Gert Marais
19
,
Nei-yuan Hsiao
19
,
Stephen Korsman
19
,
Mary-Ann Davies
20, 21
,
Lynn Tyers
5
,
Innocent Mudau
5
,
Denis York
22
,
Caroline Maslo
23
,
Dominique Goedhals
24
,
Shareef Abrahams
25
,
Oluwakemi Laguda Akingba
25, 26
,
Arghavan Alisoltani Dehkordi
27, 28
,
Adam GODZIK
28
,
Constantinos Kurt Wibmer
9
,
Bryan Trevor Sewell
29
,
Jose Lourenco
30
,
Luiz CJ Alcantara
2, 3
,
Sergei L Kosakovsky Pond
31
,
Steven Weaver
31
,
Darren Martin
4, 5
,
Richard J Lessells
1, 8
,
Jinal N. Bhiman
9, 10
,
Carolyn Williamson
5, 8, 19
,
Tulio De Oliveira
1, 8, 32
6
8
Centre for the AIDS Programme of Research In South Africa (CAPRISA), Durban, South Africa
|
12
Department of Molecular Pathology, Lancet Laboratories, Johannesburg, South Africa
|
13
19
21
Western Cape Government: Health, Cape Town, South Africa
|
22
Molecular Diagnostics Services, Durban, South Africa
|
23
Department of Quality Leadership, Netcare Hospitals, Johannesburg, South Africa
|
24
Publication type: Journal Article
Publication date: 2021-03-09
scimago Q1
wos Q1
SJR: 18.288
CiteScore: 78.1
Impact factor: 48.5
ISSN: 00280836, 14764687
PubMed ID:
33690265
Multidisciplinary
Abstract
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3–5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu–Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6–8. The 501Y.V2 variant of SARS-CoV-2 in South Africa became dominant over other variants within weeks of its emergence, suggesting that this variant is linked to increased transmissibility or immune escape.
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Tegally H. et al. Detection of a SARS-CoV-2 variant of concern in South Africa // Nature. 2021. Vol. 592. No. 7854. pp. 438-443.
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Tegally H. et al. Detection of a SARS-CoV-2 variant of concern in South Africa // Nature. 2021. Vol. 592. No. 7854. pp. 438-443.
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TY - JOUR
DO - 10.1038/s41586-021-03402-9
UR - https://www.nature.com/articles/s41586-021-03402-9
TI - Detection of a SARS-CoV-2 variant of concern in South Africa
T2 - Nature
AU - Tegally, Houriiyah
AU - Wilkinson, Eduan
AU - Giovanetti, Marta
AU - Iranzadeh, Arash
AU - Fonseca, Vagner
AU - Giandhari, Jennifer
AU - Doolabh, Deelan
AU - Pillay, Sureshnee
AU - San, Emmanuel James
AU - Msomi, Nokukhanya
AU - Mlisana, Koleka
AU - von Gottberg, Anne
AU - Walaza, Sibongile
AU - Allam, Mushal
AU - Ismail, Arshad
AU - Mohale, Thabo
AU - Glass, Allison J
AU - Engelbrecht, Susan
AU - van Zyl, Gert
AU - Preiser, Wolfgang
AU - Petruccione, Francesco
AU - Sigal, Alex
AU - Hardie, Diana
AU - Marais, Gert
AU - Hsiao, Nei-yuan
AU - Korsman, Stephen
AU - Davies, Mary-Ann
AU - Tyers, Lynn
AU - Mudau, Innocent
AU - York, Denis
AU - Maslo, Caroline
AU - Goedhals, Dominique
AU - Abrahams, Shareef
AU - Laguda Akingba, Oluwakemi
AU - Alisoltani Dehkordi, Arghavan
AU - GODZIK, Adam
AU - Wibmer, Constantinos Kurt
AU - Sewell, Bryan Trevor
AU - Lourenco, Jose
AU - Alcantara, Luiz CJ
AU - Kosakovsky Pond, Sergei L
AU - Weaver, Steven
AU - Martin, Darren
AU - Lessells, Richard J
AU - Bhiman, Jinal N.
AU - Williamson, Carolyn
AU - De Oliveira, Tulio
PY - 2021
DA - 2021/03/09
PB - Springer Nature
SP - 438-443
IS - 7854
VL - 592
PMID - 33690265
SN - 0028-0836
SN - 1476-4687
ER -
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@article{2021_Tegally,
author = {Houriiyah Tegally and Eduan Wilkinson and Marta Giovanetti and Arash Iranzadeh and Vagner Fonseca and Jennifer Giandhari and Deelan Doolabh and Sureshnee Pillay and Emmanuel James San and Nokukhanya Msomi and Koleka Mlisana and Anne von Gottberg and Sibongile Walaza and Mushal Allam and Arshad Ismail and Thabo Mohale and Allison J Glass and Susan Engelbrecht and Gert van Zyl and Wolfgang Preiser and Francesco Petruccione and Alex Sigal and Diana Hardie and Gert Marais and Nei-yuan Hsiao and Stephen Korsman and Mary-Ann Davies and Lynn Tyers and Innocent Mudau and Denis York and Caroline Maslo and Dominique Goedhals and Shareef Abrahams and Oluwakemi Laguda Akingba and Arghavan Alisoltani Dehkordi and Adam GODZIK and Constantinos Kurt Wibmer and Bryan Trevor Sewell and Jose Lourenco and Luiz CJ Alcantara and Sergei L Kosakovsky Pond and Steven Weaver and Darren Martin and Richard J Lessells and Jinal N. Bhiman and Carolyn Williamson and Tulio De Oliveira and others},
title = {Detection of a SARS-CoV-2 variant of concern in South Africa},
journal = {Nature},
year = {2021},
volume = {592},
publisher = {Springer Nature},
month = {mar},
url = {https://www.nature.com/articles/s41586-021-03402-9},
number = {7854},
pages = {438--443},
doi = {10.1038/s41586-021-03402-9}
}
Cite this
MLA
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Tegally, Houriiyah, et al. “Detection of a SARS-CoV-2 variant of concern in South Africa.” Nature, vol. 592, no. 7854, Mar. 2021, pp. 438-443. https://www.nature.com/articles/s41586-021-03402-9.
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