Plant phytochrome B is an asymmetric dimer with unique signalling potential
Publication type: Journal Article
Publication date: 2022-03-30
scimago Q1
wos Q1
SJR: 18.288
CiteScore: 78.1
Impact factor: 48.5
ISSN: 00280836, 14764687
PubMed ID:
35355010
Multidisciplinary
Abstract
Many aspects of plant photoperception are mediated by the phytochrome (Phy) family of bilin-containing photoreceptors that reversibly interconvert between inactive Pr and active Pfr conformers1,2. Despite extensive biochemical studies, full understanding of plant Phy signalling has remained unclear due to the absence of relevant 3D models. Here we report a cryo-electron microscopy structure of Arabidopsis PhyB in the Pr state that reveals a topologically complex dimeric organization that is substantially distinct from its prokaryotic relatives. Instead of an anticipated parallel architecture, the C-terminal histidine-kinase-related domains (HKRDs) associate head-to-head, whereas the N-terminal photosensory regions associate head-to-tail to form a parallelogram-shaped platform with near two-fold symmetry. The platform is internally linked by the second of two internal Per/Arnt/Sim domains that binds to the photosensory module of the opposing protomer and a preceding ‘modulator’ loop that assembles tightly with the photosensory module of its own protomer. Both connections accelerate the thermal reversion of Pfr back to Pr, consistent with an inverse relationship between dimer assembly and Pfr stability. Lopsided contacts between the HKRDs and the platform create profound asymmetry to PhyB that might imbue distinct signalling potentials to the protomers. We propose that this unique structural dynamism creates an extensive photostate-sensitive surface for conformation-dependent interactions between plant Phy photoreceptors and their signalling partners. The inactive Pr conformer of Arabidopsis phytochrome B shows a topologically complex dimeric organization that is distinct from its prokaryotic relatives.
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68
Total citations:
68
Citations from 2024:
50
(73.53%)
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GOST
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Li H. et al. Plant phytochrome B is an asymmetric dimer with unique signalling potential // Nature. 2022. Vol. 604. No. 7904. pp. 127-133.
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Li H., Burgie E. S., Gannam Z. T. K., Li H., Vierstra R. D. Plant phytochrome B is an asymmetric dimer with unique signalling potential // Nature. 2022. Vol. 604. No. 7904. pp. 127-133.
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TY - JOUR
DO - 10.1038/s41586-022-04529-z
UR - https://doi.org/10.1038/s41586-022-04529-z
TI - Plant phytochrome B is an asymmetric dimer with unique signalling potential
T2 - Nature
AU - Li, Hua
AU - Burgie, E Sethe
AU - Gannam, Zachary T K
AU - Li, Huilin
AU - Vierstra, Richard D.
PY - 2022
DA - 2022/03/30
PB - Springer Nature
SP - 127-133
IS - 7904
VL - 604
PMID - 35355010
SN - 0028-0836
SN - 1476-4687
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Li,
author = {Hua Li and E Sethe Burgie and Zachary T K Gannam and Huilin Li and Richard D. Vierstra},
title = {Plant phytochrome B is an asymmetric dimer with unique signalling potential},
journal = {Nature},
year = {2022},
volume = {604},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038/s41586-022-04529-z},
number = {7904},
pages = {127--133},
doi = {10.1038/s41586-022-04529-z}
}
Cite this
MLA
Copy
Li, Hua, et al. “Plant phytochrome B is an asymmetric dimer with unique signalling potential.” Nature, vol. 604, no. 7904, Mar. 2022, pp. 127-133. https://doi.org/10.1038/s41586-022-04529-z.