Nature Genetics

, volume 53 , issue 1 , pages 65-75

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti ¹

Burcu Darst ¹

Lilit C Moss ¹

Edward J. Saunders ²

XIN SHENG ¹

Alisha Chou ¹

Fredrick Schumacher ^{3, 4}

Ali Amin Al Olama ^{5, 6}

Sara Benlloch ⁵

Tokhir Dadaev ²

M. Brook ²

Ali Sahimi ¹

Thomas J. Hoffmann ^{7, 8}

Atsushi Takahashi ^{9, 10}

Koichi Matsuda ^{11, 12}

Yukihide Momozawa ¹³

Masashi Fujita ¹⁴

K. T. Muir ^{15, 16}

Artitaya Lophatananon ¹⁵

Peggy Wan ¹

Loïc Le Marchand ¹⁷

Lynne R. Wilkens ¹⁷

Victoria L. Stevens ¹⁸

Susan M. Gapstur ¹⁸

Brian D. Carter ¹⁸

Johanna Schleutker ^{19, 20}

Teuvo L.J. Tammela ²¹

Csilla Sipeky ¹⁹

Anssi Auvinen ²²

G. R. Giles ^{23, 24, 25}

Melissa C. Southey ²⁵

Robert J. MacInnis ^{23, 24}

Cezary Cybulski ²⁶

Dominika Wokołorczyk ²⁶

Jan Lubinski ²⁶

DAVID E. NEAL ^{27, 28, 29}

Jenny L. Donovan ³⁰

Freddie C. Hamdy ^{31, 32}

Richard C. Martin ^{30, 33, 34}

Børge G. Nordestgaard ^{35, 36}

Sune F. Nielsen ^{35, 36}

Maren Weischer ³⁶

Stig Egil Bojesen ^{35, 36}

Martin Andreas Røder ³⁷

Peter Iversen ³⁷

Jyotsna Batra ^{38, 39}

Suzanne Chambers ⁴⁰

Leire Moya ^{38, 39}

Lisa Horvath ^{41, 42}

Judith A. Clements ^{38, 39}

W. Tilley ⁴³

Gail Risbridger ^{44, 45}

Henrik Grönberg ⁴⁶

Markus Aly ^{46, 47, 48}

Robert Szulkin ^{46, 49}

Martin Eklund ⁴⁶

Tobias Nordström ^{46, 50}

Nora Pashayan ^{51, 52}

ALISON DUNNING ⁵²

Maya Ghoussaini ⁵³

Ruth C. Travis ⁵⁴

Tim J Key ⁵⁴

Elio Riboli ⁵⁵

Jong Y. Park ⁵⁶

Thomas A. Sellers ⁵⁶

Hui-Yi Lin ⁵⁷

Demetrius Albanes ⁵⁸

S L Weinstein ⁵⁸

Lorelei A. Mucci ⁵⁹

Edward Giovannucci ⁵⁹

Sara Lindström ⁶⁰

Peter Kraft ⁶¹

David J. Hunter ⁶²

Kathryn L. Penney ⁶³

Constance Turman ⁶¹

Catherine M. Tangen ⁶⁴

Phyllis J. Goodman ⁶⁴

Ian M. Thompson ⁶⁵

Robert J. Hamilton ^{66, 67}

Neil E. Fleshner ⁶⁶

Antonio Finelli ⁶⁸

Marie-Elise Parent ^{69, 70}

Janet L. Stanford ^{71, 72}

ELAINE OSTRANDER ⁷³

Milan S. Geybels ⁷¹

Stella Koutros ⁵⁸

Laura E Beane Freeman ⁵⁸

Meir Stampfer ⁶³

Alicja Wolk ^{74, 75}

Niclas Håkansson ⁷⁴

Gerald L. Andriole ⁷⁶

Robert N Hoover ⁵⁸

Mitchell J. Machiela ⁵⁸

Karina Meden Sørensen ^{77, 78}

Michael Borre ^{78, 79}

William J. Blot ^{80, 81}

Wei Zheng ⁸⁰

Edward D Yeboah ^{82, 83}

James E. Mensah ^{82, 83}

Yong-Jie Lu ⁸⁴

Hong-Wei Zhang ⁸⁵

Ninghan Feng ⁸⁶

Xueying Mao ⁸⁴

Wu Yudong ⁸⁷

Shan‐Chao Zhao ⁸⁸

Zan Sun ⁸⁹

Stephen N. Thibodeau ⁹⁰

Shannon K. McDonnell ⁹¹

Daniel J. Schaid ⁹¹

Catharine ML West ⁹²

Neil Burnet ⁹³

Gill Barnett ⁹⁴

Christiane Maier ⁹⁵

Thomas Schnoeller ⁹⁶

Manuel Luedeke ⁹⁷

Adam S. Kibel ⁹⁸

Bettina F Drake ⁷⁶

Olivier Cussenot ⁹⁹

Géraldine Cancel-Tassin ^{99, 100}

Florence Menegaux ¹⁰¹

Thérèse Truong ¹⁰¹

Yves Akoli Koudou ¹⁰²

Esther M. John ¹⁰³

Eli Marie Grindedal ¹⁰⁴

Lovise Maehle ¹⁰⁴

Kay-Tee Khaw ¹⁰⁵

Sue A. Ingles ¹⁰⁶

Mariana C. Stern ¹⁰⁶

Ana Lydia Vega ^{107, 108, 109}

Antonio Gómez-Caamaño ¹¹⁰

Laura Fachal ^{5, 107, 108, 109}

Barry S. Rosenstein ^{111, 112}

Sarah L. Kerns ¹¹³

Harry Ostrer ¹¹⁴

Manuel R. Teixeira ^{115, 116}

Paulo Paula ^{115, 117}

Andreia Brandão ^{115, 117}

Stephen Watya ¹¹⁸

Alexander Lubwama ¹¹⁸

Jeannette T. Bensen ^{119, 120}

Elizabeth T. H. Fontham ⁵⁸

James Mohler ^{120, 121}

Jack A. Taylor ^{122, 123}

Manolis Kogevinas ^{124, 125, 126, 127}

Javier Llorca ^{127, 128}

Gemma Castaño-Vinyals ^{124, 125, 126, 127}

Lisa A. Cannon Albright ^{129, 130}

Craig C. Teerlink ^{129, 130}

Chad D Huff ¹³¹

Sara S. Strom ¹³¹

L. Multigner ¹³²

Pascal Blanchet ¹³³

Brureau Laurent ¹³³

Radka Kaneva ¹³⁴

Chavdar Slavov ¹³⁵

Vanio Mitev ¹³⁴

Robin J. Leach ¹³⁶

Brandi Weaver ¹³⁶

Hermann Brenner ^{137, 138, 139}

Katarina Cuk ¹³⁷

Bernd Holleczek ¹⁴⁰

Kai-Uwe Saum ¹³⁷

Eric A. Klein ^{141, 142}

Ann W. Hsing ¹⁴³

Rick A. Kittles ¹⁴⁴

Adam B. Murphy ¹⁴⁵

CHRISTOPHER J. LOGOTHETIS ¹⁴⁶

Jeri Kim ¹⁴⁶

Susan L. Neuhausen ¹⁴⁷

Linda Steele ¹⁴⁷

Yuan Chun Ding ¹⁴⁷

William B. Isaacs ¹⁴⁸

Barbara Nemesure ¹⁴⁹

Anselm J.M. Hennis ^{149, 150}

John Carpten ¹⁵¹

Hardev Pandha ¹⁵²

A. J. Michael ¹⁵²

Kim De Ruyck ¹⁵³

Gert De Meerleer ¹⁵⁴

Piet Ost ¹⁵⁴

Jianfeng Xu ¹⁵⁵

Azad Razack ¹⁵⁶

Jasmine Lim ¹⁵⁶

Soo-Hwang Teo ¹⁵⁷

Lisa F. Newcomb ^{72, 158}

Daniel W Lin ^{72, 158}

Jay H. Fowke ¹⁵⁹

Christine Neslund-Dudas ¹⁶⁰

Benjamin A. Rybicki ¹⁶⁰

Marija Gamulin ¹⁶¹

Davor Lessel ¹⁶²

Tomislav Kulis ¹⁶³

Nawaid Usmani ^{164, 165}

Sandeep Singhal ¹⁶⁴

Matthew Parliament ^{164, 165}

Frank CLAESSENS ¹⁶⁶

Steven Joniau ¹⁶⁷

Thomas Van den Broeck ^{166, 167}

Manuela Gago-Dominguez ^{168, 169}

Jose Esteban Castelao ¹⁷⁰

Maria Elena Martinez ¹⁷¹

Samantha Larkin ¹⁷²

Paul A. TOWNSEND ^{152, 173}

Claire Aukim Hastie ¹⁵²

William H. Bush ¹⁷⁴

Melinda C. Aldrich ¹⁷⁵

Dana C. Crawford ¹⁷⁴

Shiv Srivastava ¹⁷⁶

Jennifer C Cullen ¹⁷⁶

Gyorgy Petrovics ¹⁷⁶

Graham Casey ¹⁷⁷

Monique J. Roobol ¹⁷⁸

Guido Jenster ¹⁷⁸

Ron H. N. van Schaik ¹⁷⁹

Jennifer J. Hu ¹⁸⁰

Maureen Sanderson ¹⁸¹

Rohit Varma ¹⁸²

Roberta McKean-Cowdin ¹

Mina Torres ¹⁸²

Nicholas Mancuso ¹

Sonja I Berndt ⁵⁸

Stephen K. Van Den Eeden ^{183, 184}

Douglas F. Easton ⁵

STEPHEN CHANOCK ⁵⁸

Michael B. Cook ⁵⁸

Fredrik Wiklund ⁴⁶

Hidewaki Nakagawa ¹⁴

John S Witte ^{7, 8, 184}

Rosalind Eeles ^{2, 185}

Zsofia Kote-Jarai ²

Christopher Haiman ¹

Hide authors affiliations Show authors affiliations: 185 affiliations

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, USA |

the Institute of Cancer Research, London, UK |

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, USA |

⁴

Seidman Cancer Center, University Hospitals, Cleveland, USA |

⁵

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK |

⁶

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK |

⁷

Department of Epidemiology and Biostatistics, University of California, San Francisco, USA |

⁸

Institute for Human Genetics, University of California, San Francisco, USA |

⁹

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan |

¹⁰

Department of Genomic Medicine, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan |

¹¹

Laboratory of Clinical Genome Sequencing, Department of Computational biology and medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan |

¹²

Biobank, Tokyo, Japan |

¹³

Laboratory for Genotyping Development, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan |

¹⁴

Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan |

¹⁵

Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK |

¹⁶

Warwick Medical School, University of Warwick, Coventry, UK |

¹⁷

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, USA |

¹⁸

Behavioral and Epidemiology Research Group, Research Program, American Cancer Society, Atlanta, USA |

¹⁹

Institute of Biomedicine, University of Turku, Turku, Finland |

²⁰

Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland |

²¹

Department of Urology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland |

²²

Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland |

²³

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia |

²⁴

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia |

²⁵

Precision Medicine, School of Clinical Sciences At Monash Health, Monash University, Clayton, Australia

Monash University

Monash Health

²⁶

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland |

²⁷

Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK |

²⁸

University of Cambridge, Department of Oncology, Addenbrooke’s Hospital, Cambridge, UK |

²⁹

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK |

³⁰

Population Health Sciences, Bristol Medical School, University Of Bristol, Bristol, UK |

³¹

Nuffield department of surgical sciences, University of Oxford, Oxford, UK |

³²

Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK |

³³

National Institute for Health Research (NIHR) Biomedical Research Centre, University of Bristol, Bristol, UK |

³⁴

Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK |

³⁵

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |

³⁶

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark |

³⁷

Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark |

³⁸

Australian Prostate Cancer Research Centre–Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia |

³⁹

Translational Research Institute, Brisbane, Australia |

⁴⁰

UNIVERSITY OF TECHNOLOGY, SYDNEY, AUSTRALIA |

⁴¹

Chris O’Brien Lifehouse (COBLH), Camperdown, Sydney, Australia |

⁴²

Garvan Institute of Medical Research, Sydney, Australia |

⁴³

Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, Australia |

⁴⁴

Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia |

⁴⁵

Prostate Cancer Translational Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia |

⁴⁶

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden |

⁴⁷

Department of Molecular Medicine and Surgery, Karolinska Institutet, and Department of Urology, Karolinska University Hospital, Solna, Stockholm, Sweden

Karolinska Institute

Karolinska University Hospital

⁴⁸

Department of urology, Karolinska University Hospital, Stockholm, Sweden |

⁴⁹

SDS Life Science, Danderyd, Sweden |

⁵⁰

Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden |

⁵¹

Department of Applied Health Research, University College London, London, UK |

⁵²

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Cambridge, UK |

⁵³

Open Targets, Wellcome Sanger Institute, Hinxton, UK |

⁵⁴

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK |

⁵⁵

Department of Epidemiology and Biostatistics, School of Public health, Imperial College London, London, UK |

⁵⁶

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, USA |

⁵⁷

School of Public Health, Louisiana State University Health Sciences Center, New Orleans, USA |

⁵⁸

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, USA |

⁵⁹

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA |

⁶⁰

Department of Epidemiology, University of Washington, Seattle, USA |

⁶¹

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA |

⁶²

Nuffield Department of Population Health, University of Oxford, Oxford, UK |

⁶³

Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, USA

Harvard University

Brigham and Women's Hospital

⁶⁴

SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, USA |

⁶⁵

CHRISTUS Santa Rosa Hospital – Medical Center, San Antonio, USA |

⁶⁶

Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Canada |

⁶⁷

Department of Surgery (Urology), University of Toronto, Toronto, Canada |

⁶⁸

Division of Urology, Princess Margaret Cancer Centre, Toronto, Canada |

⁶⁹

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, Canada |

⁷⁰

Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Canada |

⁷¹

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA |

⁷²

Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA |

⁷³

National Human Genome Research Institute, National Institutes of Health, Bethesda, USA |

⁷⁴

Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden |

⁷⁵

Department of Surgical sciences, Uppsala University, Uppsala, Sweden |

⁷⁶

Washington University School of Medicine, St Louis, USA |

⁷⁷

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark |

⁷⁸

Department of Clinical medicine, Aarhus University, Aarhus, Denmark |

⁷⁹

Department of Urology, Aarhus University Hospital, Aarhus, Denmark |

⁸⁰

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA |

⁸¹

International Epidemiology Institute, Rockville, USA |

⁸²

University of Ghana Medical School, Accra, Ghana |

⁸³

Korle BU Teaching Hospital, Accra, Ghana |

⁸⁴

Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK |

⁸⁵

Second Military Medical University, Shanghai, China |

⁸⁶

Wuxi Second Hospital, Nanjing Medical University, Wuxi, China |

⁸⁷

Department of Urology, First Affiliated Hospital, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China |

⁸⁸

Department of Urology, NanFang Hospital, Southern Medical University, Guangzhou, China |

⁸⁹

The People’s Hospital of Liaoning Province, The People’s Hospital of China Medical University, Shenyang, China |

⁹⁰

Department of laboratory medicine and pathology, Mayo Clinic, Rochester, USA |

⁹¹

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, USA |

⁹²

Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK

University of Manchester

Manchester Academic Health Science Centre

⁹³

Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, and the Christie NHS Foundation Trust, Manchester, UK

University of Manchester

Manchester Academic Health Science Centre

⁹⁴

University of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK |

⁹⁵

Humangenetik Tuebingen, Tuebingen, Germany |

⁹⁶

Department of Urology, University Hospital, Ulm, Germany |

⁹⁷

genetikum, Neu-Ulm, Germany |

⁹⁸

Division of Urologic Surgery, Brigham and Womens Hospital, Boston, USA |

⁹⁹

Sorbonne Universite, Tenon Hospital, Paris, France |

¹⁰⁰

CeRePP, Tenon Hospital, Paris, France |

¹⁰¹

Exposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France

Université Paris-Saclay

French Institute of Health and Medical Research

Institut Gustave Roussy

¹⁰²

CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Villejuif, France

Université Paris-Saclay

French Institute of Health and Medical Research

¹⁰³

Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA |

¹⁰⁴

Department of medical genetics, Oslo University Hospital, Oslo, Norway |

¹⁰⁵

Clinical Gerontology Unit, University of Cambridge, Cambridge, UK |

¹⁰⁶

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, USA |

¹⁰⁷

Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain |

¹⁰⁸

Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain |

¹⁰⁹

Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain |

¹¹⁰

Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain |

¹¹¹

Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA |

¹¹²

Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, USA |

¹¹³

Department of Radiation Oncology, University of Rochester Medical Center, Rochester, USA |

¹¹⁴

Department of Pathology, Albert Einstein College of Medicine, Bronx, USA |

¹¹⁵

Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal |

¹¹⁶

Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal |

¹¹⁷

Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal |

¹¹⁸

Uro Care, Kampala, Uganda |

¹¹⁹

Department of Epidemiology, University of North Carolina At Chapel Hill, Chapel Hill, USA |

¹²⁰

Lineberger Comprehensive Cancer Center, University of North Carolina At Chapel Hill, Chapel Hill, USA |

¹²¹

Department of Urology, Roswell Park Cancer Institute, Buffalo, USA |

¹²²

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, USA |

¹²³

Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, USA |

¹²⁴

ISGlobal, Barcelona, Spain |

¹²⁵

IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain |

¹²⁶

Universitat Pompeu Fabra (UPF), Barcelona, Spain |

¹²⁷

CIBER Epidemiología y Salud pública (CIBERESP), Madrid, Spain |

¹²⁸

University of Cantabria–IDIVAL, Santander, Spain

University of Cantabria

Instituto de Investigación Marqués de Valdecilla

¹²⁹

Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, USA |

¹³⁰

George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, USA |

¹³¹

Department of Epidemiology, the University of Texas M. D. Anderson Cancer Center, Houston, USA |

¹³²

University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Rennes, France

French Institute of Health and Medical Research

Université de Rennes

Research Institute for Environmental and Occupation Health

¹³³

CHU de Pointe-à-Pitre, University of the French Antilles, University of Rennes, Inserm, EHESP, Irset (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, France

University of the French Antilles

French Institute of Health and Medical Research

Université de Rennes

Research Institute for Environmental and Occupation Health

¹³⁴

Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria |

¹³⁵

Department of Urology and Alexandrovska University Hospital, Medical University of Sofia, Sofia, Bulgaria |

¹³⁶

Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, USA |

¹³⁷

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany |

¹³⁸

German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany |

¹³⁹

Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany |

¹⁴⁰

Saarland cancer registry, Saarbrücken, Germany |

¹⁴¹

Cleveland Clinic Lerner Research Institute, Cleveland, USA |

¹⁴²

Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, USA |

¹⁴³

Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, USA |

¹⁴⁴

Division of Health Equities, Department of Population Sciences, City of Hope, Duarte, USA |

¹⁴⁵

Department of Urology, Northwestern University, Chicago, USA |

¹⁴⁶

Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, USA |

¹⁴⁷

Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, USA |

¹⁴⁸

James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, USA |

¹⁴⁹

Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, USA |

¹⁵⁰

Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados |

¹⁵¹

Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, USA |

¹⁵²

Faculty of Health and Medical Sciences, The University of Surrey, Guildford, UK |

¹⁵³

Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium |

¹⁵⁴

Department of Radiotherapy, Ghent University Hospital, Gent, Belgium |

¹⁵⁵

Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, USA |

¹⁵⁶

Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia |

¹⁵⁷

Cancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Malaysia |

¹⁵⁸

Department of Urology, University of Washington, Seattle, USA |

¹⁵⁹

Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, USA |

¹⁶⁰

Department of Public Health Sciences, Henry Ford Hospital, Detroit, USA |

¹⁶¹

Department of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia |

¹⁶²

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany |

¹⁶³

Department of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia |

¹⁶⁴

Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Canada |

¹⁶⁵

Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Canada |

¹⁶⁶

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium |

¹⁶⁷

Department of urology, University Hospitals Leuven, Leuven, Belgium |

¹⁶⁸

Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain |

¹⁶⁹

University of California San Diego, Moores Cancer Center, La Jolla, USA |

¹⁷⁰

Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo, Spain |

¹⁷¹

Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, USA |

¹⁷²

The University of Southampton, Southampton General Hospital, Southampton, UK |

¹⁷³

Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK

University of Manchester

Manchester Academic Health Science Centre

¹⁷⁴

Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, USA |

¹⁷⁵

Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, USA |

¹⁷⁶

Center for Prostate Disease Research, Uniformed Services University, Bethesda, USA |

¹⁷⁷

Center for public health genomics, Department of public health sciences, University of Virginia, Charlottesville, USA |

¹⁷⁸

Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands |

¹⁷⁹

Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands |

¹⁸⁰

The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, USA |

¹⁸¹

Department of Family and Community Medicine, Meharry Medical College, Nashville, USA |

¹⁸²

Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, USA |

¹⁸³

Division of Research, Kaiser Permanente, Northern California, Oakland, USA |

¹⁸⁴

Department of Urology, University of California San Francisco, San Francisco, USA |

¹⁸⁵

Royal Marsden NHS Foundation Trust, London, UK |

Publication type: Journal Article

Publication date: 2021-01-04

Springer Nature

Nature Genetics

scimago Q1

wos Q1

SJR: 16.586

CiteScore: 45.1

Impact factor: 29.0

ISSN: 10614036, 15461718

DOI: 10.1038/s41588-020-00748-0

Copy DOI

PubMed ID: 33398198

Genetics

Abstract

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84–5.29) for men of European ancestry to 3.74 (95% CI, 3.36–4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14–2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71–0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

Found

2 citations

Mark Sean

42 publications, 430 citations, 16 reviews

h-index: 12

University of Pretoria

Research interests

Physiology

1 citation

Toscano Emily

PhD in Biological/biomedical sciences

15 publications, 81 citations

h-index: 4

Autonomous University of Barcelona

Developmental biology

Molecular biology

Regenerative biology

Top-30

Journals

	2 4 6 8 10 12 14 16 18
Nature Communications	Nature Communications, 17, 4.5% Nature Communications 17 publications, 4.5%
Cancers	Cancers, 15, 3.97% Cancers 15 publications, 3.97%
European Urology	European Urology, 12, 3.17% European Urology 12 publications, 3.17%
medRxiv : the preprint server for health sciences	medRxiv : the preprint server for health sciences, 12, 3.17% medRxiv : the preprint server for health sciences 12 publications, 3.17%
Prostate	Prostate, 11, 2.91% Prostate 11 publications, 2.91%
Nature Genetics	Nature Genetics, 8, 2.12% Nature Genetics 8 publications, 2.12%
Journal of the National Cancer Institute	Journal of the National Cancer Institute, 8, 2.12% Journal of the National Cancer Institute 8 publications, 2.12%
Cancer Epidemiology Biomarkers and Prevention	Cancer Epidemiology Biomarkers and Prevention, 8, 2.12% Cancer Epidemiology Biomarkers and Prevention 8 publications, 2.12%
Prostate Cancer and Prostatic Diseases	Prostate Cancer and Prostatic Diseases, 7, 1.85% Prostate Cancer and Prostatic Diseases 7 publications, 1.85%
American Journal of Human Genetics	American Journal of Human Genetics, 7, 1.85% American Journal of Human Genetics 7 publications, 1.85%
Journal of Clinical Oncology	Journal of Clinical Oncology, 5, 1.32% Journal of Clinical Oncology 5 publications, 1.32%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 5, 1.32% International Journal of Molecular Sciences 5 publications, 1.32%
Human Genetics and Genomics Advances	Human Genetics and Genomics Advances, 5, 1.32% Human Genetics and Genomics Advances 5 publications, 1.32%
European Urology Open Science	European Urology Open Science, 5, 1.32% European Urology Open Science 5 publications, 1.32%
European urology oncology	European urology oncology, 5, 1.32% European urology oncology 5 publications, 1.32%
Cancer Letters	Cancer Letters, 4, 1.06% Cancer Letters 4 publications, 1.06%
Genes	Genes, 4, 1.06% Genes 4 publications, 1.06%
Frontiers in Genetics	Frontiers in Genetics, 4, 1.06% Frontiers in Genetics 4 publications, 1.06%
Human Molecular Genetics	Human Molecular Genetics, 4, 1.06% Human Molecular Genetics 4 publications, 1.06%
Journal of Translational Medicine	Journal of Translational Medicine, 3, 0.79% Journal of Translational Medicine 3 publications, 0.79%
British Journal of Cancer	British Journal of Cancer, 3, 0.79% British Journal of Cancer 3 publications, 0.79%
Nature Medicine	Nature Medicine, 3, 0.79% Nature Medicine 3 publications, 0.79%
Communications Biology	Communications Biology, 3, 0.79% Communications Biology 3 publications, 0.79%
Genetics in Medicine	Genetics in Medicine, 3, 0.79% Genetics in Medicine 3 publications, 0.79%
Scientific Reports	Scientific Reports, 3, 0.79% Scientific Reports 3 publications, 0.79%
PLoS Genetics	PLoS Genetics, 3, 0.79% PLoS Genetics 3 publications, 0.79%
International Journal of Cancer	International Journal of Cancer, 3, 0.79% International Journal of Cancer 3 publications, 0.79%
Ca-A Cancer Journal for Clinicians	Ca-A Cancer Journal for Clinicians, 3, 0.79% Ca-A Cancer Journal for Clinicians 3 publications, 0.79%
Genetic Epidemiology	Genetic Epidemiology, 3, 0.79% Genetic Epidemiology 3 publications, 0.79%
	2 4 6 8 10 12 14 16 18

Publishers

	10 20 30 40 50 60 70 80 90
Springer Nature	Springer Nature, 84, 22.22% Springer Nature 84 publications, 22.22%
Elsevier	Elsevier, 61, 16.14% Elsevier 61 publications, 16.14%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 49, 12.96% Cold Spring Harbor Laboratory 49 publications, 12.96%
Wiley	Wiley, 39, 10.32% Wiley 39 publications, 10.32%
MDPI	MDPI, 30, 7.94% MDPI 30 publications, 7.94%
Oxford University Press	Oxford University Press, 24, 6.35% Oxford University Press 24 publications, 6.35%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 20, 5.29% American Association for Cancer Research (AACR) 20 publications, 5.29%
Frontiers Media S.A.	Frontiers Media S.A., 10, 2.65% Frontiers Media S.A. 10 publications, 2.65%
American Society of Clinical Oncology (ASCO)	American Society of Clinical Oncology (ASCO), 7, 1.85% American Society of Clinical Oncology (ASCO) 7 publications, 1.85%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 6, 1.59% Public Library of Science (PLoS) 6 publications, 1.59%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 5, 1.32% Ovid Technologies (Wolters Kluwer Health) 5 publications, 1.32%
American Medical Association (AMA)	American Medical Association (AMA), 5, 1.32% American Medical Association (AMA) 5 publications, 1.32%
American Society for Clinical Investigation	American Society for Clinical Investigation, 2, 0.53% American Society for Clinical Investigation 2 publications, 0.53%
eLife Sciences Publications	eLife Sciences Publications, 2, 0.53% eLife Sciences Publications 2 publications, 0.53%
Taylor & Francis	Taylor & Francis, 2, 0.53% Taylor & Francis 2 publications, 0.53%
The Korean Urological Association	The Korean Urological Association, 2, 0.53% The Korean Urological Association 2 publications, 0.53%
Annual Reviews	Annual Reviews, 2, 0.53% Annual Reviews 2 publications, 0.53%
Research Square Platform LLC	Research Square Platform LLC, 2, 0.53% Research Square Platform LLC 2 publications, 0.53%
Massachusetts Medical Society	Massachusetts Medical Society, 2, 0.53% Massachusetts Medical Society 2 publications, 0.53%
PeerJ	PeerJ, 2, 0.53% PeerJ 2 publications, 0.53%
The Royal Society	The Royal Society, 1, 0.26% The Royal Society 1 publication, 0.26%
SAGE	SAGE, 1, 0.26% SAGE 1 publication, 0.26%
American Society for Nutrition	American Society for Nutrition, 1, 0.26% American Society for Nutrition 1 publication, 0.26%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.26% Mary Ann Liebert 1 publication, 0.26%
Hans Publishers	Hans Publishers, 1, 0.26% Hans Publishers 1 publication, 0.26%
AME Publishing Company	AME Publishing Company, 1, 0.26% AME Publishing Company 1 publication, 0.26%
Bioscientifica	Bioscientifica, 1, 0.26% Bioscientifica 1 publication, 0.26%
XMLink	XMLink, 1, 0.26% XMLink 1 publication, 0.26%
	10 20 30 40 50 60 70 80 90

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

378

Cite this

GOST |

Cite this

GOST Copy

Conti D. V. et al. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction // Nature Genetics. 2021. Vol. 53. No. 1. pp. 65-75.

GOST all authors (up to 50) Copy

RIS |

Cite this

RIS

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Conti,

author = {David V. Conti and Burcu Darst and Lilit C Moss and Edward J. Saunders and XIN SHENG and Alisha Chou and Fredrick Schumacher and Ali Amin Al Olama and Sara Benlloch and Tokhir Dadaev and M. Brook and Ali Sahimi and Thomas J. Hoffmann and Atsushi Takahashi and Koichi Matsuda and Yukihide Momozawa and Masashi Fujita and K. T. Muir and Artitaya Lophatananon and Peggy Wan and Loïc Le Marchand and Lynne R. Wilkens and Victoria L. Stevens and Susan M. Gapstur and Brian D. Carter and Johanna Schleutker and Teuvo L.J. Tammela and Csilla Sipeky and Anssi Auvinen and G. R. Giles and Melissa C. Southey and Robert J. MacInnis and Cezary Cybulski and Dominika Wokołorczyk and Jan Lubinski and DAVID E. NEAL and Jenny L. Donovan and Freddie C. Hamdy and Richard C. Martin and Børge G. Nordestgaard and Sune F. Nielsen and Maren Weischer and Stig Egil Bojesen and Martin Andreas Røder and Peter Iversen and Jyotsna Batra and Suzanne Chambers and Leire Moya and Lisa Horvath and Judith A. Clements and others},

title = {Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction},

journal = {Nature Genetics},

year = {2021},

volume = {53},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038/s41588-020-00748-0},

number = {1},

pages = {65--75},

doi = {10.1038/s41588-020-00748-0}

}

MLA

Cite this

MLA Copy

Conti, David V., et al. “Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.” Nature Genetics, vol. 53, no. 1, Jan. 2021, pp. 65-75. https://doi.org/10.1038/s41588-020-00748-0.

Publisher

Springer Nature

Journal

Nature Genetics

scimago Q1

wos Q1

SJR

16.586

CiteScore

45.1

Impact factor

29.0

ISSN

10614036 (Print)

15461718 (Electronic)