Nature Genetics

, volume 53 , issue 6 , pages 817-829

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Niamh Mullins ^{1, 2}

Andreas J. Forstner ^{3, 4, 5}

Kevin S. O'Connell ^{6, 7}

Brandon Coombes ⁸

Jonathan R. I. Coleman ^{9, 10}

Zhen Qiao ¹¹

Thomas D. Als ^{12, 13, 14}

Tim B. Bigdeli ^{15, 16}

Sigrid Børte ^{17, 18, 19}

Julien Bryois ²⁰

Alexander W. Charney ²

Ole Kristian Drange ^{21, 22}

Michael J Gandal ²³

Saskia P. Hagenaars ^{9, 10}

Masashi IKEDA ²⁴

Nolan Kamitaki ^{25, 26}

Minsoo Kim ²³

Kristi Krebs ²⁷

Georgia Panagiotaropoulou ²⁸

Brian M Schilder ^{1, 29, 30, 31}

Laura G Sloofman ¹

Stacy Steinberg ³²

Vassily Trubetskoy ²⁸

Bendik S. Winsvold ^{19, 33}

HONG-HEE WON ³⁴

Liliya Abramova ³⁵

Kristina Adorjan ^{36, 37}

Esben Agerbo ^{14, 38, 39}

Mariam Al Eissa ⁴⁰

Diego Albani ⁴¹

Ney Alliey-Rodriguez ^{42, 43}

Adebayo Anjorin ⁴⁴

Verneri Antilla ⁴⁵

Anastasia Antoniou ⁴⁶

Swapnil Awasthi ²⁸

Ji Hyun Baek ⁴⁷

Marie Bækvad-Hansen ^{14, 48}

Nicholas Bass ⁴⁰

Michael Bauer ⁴⁹

Eva C Beins ³

Sarah E. Bergen ²⁰

Armin Birner ⁵⁰

Carsten Bøcker Pedersen ^{14, 38, 39}

Erlend Bøen ⁵¹

Marco P. Boks ⁵²

Rosa Bosch ^{53, 54, 55, 56}

Murielle Brum ⁵⁷

Ben M. Brumpton ¹⁹

Nathalie Brunkhorst Kanaan ⁵⁷

Monika Budde ³⁶

Jonas Bybjerg-Grauholm ^{14, 48}

William Byerley ⁵⁸

Murray Cairns ⁵⁹

Miquel Casas ^{53, 54, 55, 56}

Pablo Cervantes ⁶⁰

Toni-Kim Clarke ⁶¹

Cristiana Cruceanu ^{60, 62}

Alfredo Cuellar Barboza ^{63, 64}

Julie Cunningham ⁶⁵

David Curtis ^{66, 67}

Piotr M. Czerski ⁶⁸

Anders M. Dale ⁶⁹

Nina Dalkner ⁵⁰

Friederike S David ³

Franziska Degenhardt ^{3, 70}

Srdjan Djurovic ^{71, 72}

Amanda L Dobbyn ^{1, 2}

Athanassios Douzenis ⁴⁶

Torbjørn Elvsåshagen ^{18, 73, 74}

Valentina Escott-Price ⁷⁵

I. Nicol Ferrier ⁷⁶

Alessia Fiorentino ⁴⁰

Tatiana M. Foroud ⁷⁷

Liz Forty ⁷⁵

Josef Frank ⁷⁸

Oleksandr Frei ^{6, 18}

Nelson B. Freimer ^{23, 79}

Louise Frisén ⁸⁰

Katrin Gade ^{36, 81}

Julie Garnham ⁸²

Joel Gelernter ^{83, 84, 85}

Marianne Giørtz Pedersen ^{14, 38, 39}

Ian R. Gizer ⁸⁶

Scott D. Gordon ⁸⁷

Katherine Gordon-Smith ⁸⁸

Tiffany A. Greenwood ⁸⁹

JAKOB GROVE ^{12, 13, 14, 90}

José Guzman-Parra ⁹¹

Kyooseob Ha ⁹²

Magnus Haraldsson ⁹³

Martin Hautzinger ⁹⁴

Urs Heilbronner ³⁶

Dennis Hellgren ²⁰

Stefan Herms ^{3, 95, 96}

Per Hoffmann ^{3, 95, 96}

Peter A Holmans ⁷⁵

Laura Huckins ^{1, 2}

Stéphane Jamain ^{97, 98}

Jessica S Johnson ^{1, 2}

Janos L Kalman ^{36, 37, 99}

Yoichiro Kamatani ^{100, 101}

James L. Kennedy ^{102, 103, 104, 105}

Sarah Kittel-Schneider ^{57, 106}

James A. Knowles ^{107, 108}

Manolis Kogevinas ¹⁰⁹

Maria Koromina ¹¹⁰

Thorsten M. Kranz ⁵⁷

Henry R. Kranzler ^{111, 112}

Michiaki Kubo ¹¹³

Ralph Kupka ^{114, 115, 116}

Steven A Kushner ¹¹⁷

Catharina Lavebratt ^{118, 119}

Jacob Lawrence ¹²⁰

Markus Leber ¹²¹

Heon-Jeong Lee ¹²²

Phil H Lee ¹²³

Shawn E. Levy ¹²⁴

Catrin Lewis ⁷⁵

Calwing Liao ^{125, 126}

Susanne Lucae ⁶²

Martin Lundberg ^{118, 119}

Donald J Macintyre ¹²⁷

Sigurdur H Magnusson ³²

Wolfgang Maier ¹²⁸

Adam Maihofer ⁸⁹

Dolores Malaspina ^{1, 2}

Eirini Maratou ¹²⁹

Lina Martinsson ⁸⁰

Manuel Mattheisen ^{12, 13, 14, 106, 130}

Steven A. McCarroll ^{25, 26}

Nathaniel W Mcgregor ¹³¹

Peter McGuffin ⁹

James D. McKay ¹³²

Helena Medeiros ¹⁰⁸

Sarah E. Medland ⁸⁷

Vincent Millischer ^{118, 119}

Grant W. Montgomery ¹¹

Jennifer L. Moran ^{25, 133}

Derek W. Morris ¹³⁴

Thomas W. Mühleisen ^{4, 95}

Niamh O'Brien ⁴⁰

Claire O'Donovan ⁸²

Loes M. Olde Loohuis ^{23, 79}

Lilijana Oruc ¹³⁵

Sergi Papiol ^{36, 37}

Antonio F. Pardiñas ⁷⁵

Amy Perry ⁸⁸

Andrea Pfennig ⁴⁹

Evgenia Porichi ⁴⁶

James B. Potash ¹³⁶

Digby Quested ^{137, 138}

Towfique Raj ^{1, 29, 30, 31}

Mark H. Rapaport ¹³⁹

J. RAYMOND DePAULO ¹³⁶

Eline J Regeer ¹⁴⁰

John P. Rice ¹⁴¹

Fabio Rivas ⁹¹

Margarita Rivera ^{142, 143}

Julian Roth ¹⁰⁶

Panos Roussos ^{1, 2, 29}

Douglas M. Ruderfer ¹⁴⁴

Cristina Sánchez Mora ^{53, 54, 56, 145}

Eva C Schulte ^{36, 37}

Fanny Senner ^{36, 37}

Sally Sharp ⁴⁰

Paul D. Shilling ⁸⁹

Engilbert Sigurdsson ^{93, 146}

Lea Sirignano ⁷⁸

Claire Slaney ⁸²

Olav B. Smeland ^{6, 7}

Daniel J. Smith ¹⁴⁷

Janet L. Sobell ¹⁴⁸

Christine Søholm Hansen ^{14, 48}

María Soler Artigas ^{53, 54, 56, 145}

Anne T Spijker ¹⁴⁹

Dan J. Stein ¹⁵⁰

John S. Strauss ¹⁰²

Beata Świątkowska ¹⁵¹

Chikashi Terao ¹⁰¹

Thorgeir E. Thorgeirsson ³²

Claudio Toma ^{152, 153, 154}

Paul Tooney ⁵⁹

Evangelia-Eirini Tsermpini ¹¹⁰

Marquis P Vawter ¹⁵⁵

Helmut Vedder ¹⁵⁶

James T.R. Walters ⁷⁵

Stephanie H. Witt ⁷⁸

Simon Xi ¹⁵⁷

Wei Xu ¹⁵⁸

Jessica Mei Kay Yang ⁷⁵

Allan H Young ^{159, 160}

Hannah Young ¹

Peter P. Zandi ¹³⁶

Hang Zhou ^{83, 84}

Lea Zillich ⁷⁸

Rolf Adolfsson ¹⁶¹

Ingrid Agartz ^{51, 130, 162}

Martin Alda ^{82, 163}

Lars Alfredsson ¹⁶⁴

Gulja Babadjanova ¹⁶⁵

Lena Backlund ^{118, 119}

Bernhard T. Baune ^{166, 167, 168}

Frank Bellivier ^{169, 170}

Susanne Bengesser ⁵⁰

Wade H. Berrettini ¹⁷¹

Douglas H.R. Blackwood ⁶¹

Michael Boehnke ¹⁷²

Anders D. Børglum ^{14, 173, 174}

Gerome Breen ^{9, 10}

Vaughan J Carr ¹⁷⁵

Stanley Catts ¹⁷⁶

Aiden Corvin ¹⁷⁷

Nicholas Craddock ⁷⁵

Udo Dannlowski ¹⁶⁶

Dimitris Dikeos ¹⁷⁸

Tonu Esko ^{26, 27, 179, 180}

Bruno Etain ^{169, 170}

Panagiotis Ferentinos ^{9, 46}

Mark Frye ⁶⁴

Janice M. Fullerton ^{152, 153}

Micha Gawlik ¹⁰⁶

Elliot S. Gershon ^{42, 181}

Fernando S. Goes ¹³⁶

Melissa J Green ^{152, 175}

Maria Grigoroiu-Serbanescu ¹⁸²

Joanna Hauser ⁶⁸

Frans Henskens ⁵⁹

Jan Hillert ⁸⁰

Kyung Sue Hong ⁴⁷

David M. Hougaard ^{14, 48}

Christina M. Hultman ²⁰

Kristian Hveem ^{19, 183}

Nakao Iwata ²⁴

Assen V. Jablensky ¹⁸⁴

Ian Jones ⁷⁵

Lisa A. Jones ⁸⁸

René S. Kahn ^{2, 52}

John R. Kelsoe ⁸⁹

George Kirov ⁷⁵

Mikael Landén ^{20, 185}

Marion Leboyer ^{97, 98, 186}

Cathryn M. Lewis ^{9, 10, 187}

Qingqin S. Li ¹⁸⁸

Jolanta Lissowska ¹⁸⁹

Christine Lochner ¹⁹⁰

Carmel Loughland ⁵⁹

Nicholas G. Martin ^{87, 191}

Carol A. Mathews ¹⁹²

Fermin Mayoral ⁹¹

Susan L. McElroy ¹⁹³

Andrew M. McIntosh ^{127, 194}

Francis J. McMahon ¹⁹⁵

Ingrid Melle ^{6, 196}

Michie Patricia ⁵⁹

Lili Milani ²⁷

Philip B. Mitchell ¹⁷⁵

Gunnar Morken ^{21, 197}

Ole Mors ^{14, 198}

Preben Bo Mortensen ^{12, 14, 38, 39}

Bryan Mowry ¹⁷⁶

Bertram Müller-Myhsok ^{62, 199, 200}

Richard M. Myers ¹²⁴

Benjamin M Neale ^{25, 45, 179}

Caroline M. Nievergelt ^{89, 201}

Merete Nordentoft ^{14, 202}

Markus M. Nöthen ³

Michael C. O’Donovan ⁷⁵

Ketil J. Oedegaard ^{203, 204}

Tomas Olsson ²⁰⁵

Michael J Owen ⁷⁵

Sara A. Paciga ²⁰⁶

Chris Pantelis ²⁰⁷

Carlos Pato ¹⁰⁸

MICHELE T. PATO ¹⁰⁸

George P. Patrinos ^{110, 208, 209}

Roy H. Perlis ^{210, 211}

Danielle Posthuma ^{212, 213}

Josep Antoni Ramos Quiroga ^{53, 54, 55, 56}

Andreas Reif ⁵⁷

Eva Z. Reininghaus ⁵⁰

Marta Ribasés ^{53, 54, 56, 145}

Marcella Rietschel ⁷⁸

Stephan Ripke ^{25, 28, 45}

Guy A. Rouleau ^{126, 214}

Takeo SAITO ²⁴

Ulrich Schall ⁵⁹

Martin Schalling ^{118, 119}

Peter R. Schofield ^{152, 153}

Thomas G. Schulze ^{36, 78, 81, 136, 215}

Laura J. Scott ¹⁷²

Rodney J Scott ⁵⁹

Alessandro Serretti ²¹⁶

Cynthia Shannon Weickert ^{152, 175, 217}

Jordan W. Smoller ^{25, 133, 218}

Hreinn Stefansson ³²

Kari Stefansson ^{32, 219}

Eystein Stordal ^{220, 221}

Fabian Streit ⁷⁸

Patrick F. Sullivan ^{20, 222, 223}

Gustavo Turecki ²²⁴

Arne E Vaaler ²²⁵

Eduard Vieta ²²⁶

John B. Vincent ¹⁰²

Irwin D. Waldman ²²⁷

Thomas W. Weickert ^{152, 175, 217}

Thomas Werge ^{14, 228, 229, 230}

Naomi R Wray ^{11, 231}

John-Anker Zwart ^{18, 19, 33}

Joanna M. Biernacka ^{8, 64}

John I. Nurnberger ²³²

Sven Cichon ^{3, 4, 95, 96}

Howard J. Edenberg ^{77, 233}

Eli A. Stahl ^{1, 2, 179}

Andrew McQuillin ⁴⁰

Arianna Di Florio ^{75, 223}

Roel A. Ophoff ^{23, 79, 117, 234}

Ole A. Andreassen ^{6, 7}

Hide authors affiliations Show authors affiliations: 234 affiliations

Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, USA |

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA |

Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany |

⁴

Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany |

⁵

Centre for Human Genetics, University of Marburg, Marburg, Germany |

⁶

Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway |

⁷

NORMENT, University of Oslo, Oslo, Norway |

⁸

Department of Health Sciences Research, Mayo Clinic, Rochester, USA |

⁹

Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK |

¹⁰

NIHR Maudsley BRC, King’s College London, London, UK

King's College London

NIHR Maudsley Biomedical Research Centre

¹¹

Institute for Molecular Bioscience, the University of Queensland, Brisbane, Australia |

¹²

iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark |

¹³

Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark |

¹⁴

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark |

¹⁵

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, USA |

¹⁶

VA NY Harbor Healthcare System, Brooklyn, USA |

¹⁷

Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway |

¹⁸

Institute of clinical medicine, University of Oslo, Oslo, Norway |

¹⁹

K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway |

²⁰

Department of medical epidemiology and biostatistics, Karolinska Institutet, Stockholm, Sweden |

²¹

Department of Mental Health, Faculty of Medicine and Health sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway |

²²

Department of Østmarka, Division of Mental Health Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway |

²³

Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, USA |

²⁴

Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan |

²⁵

Stanley Center for Psychiatric Research, Broad Institute, Cambridge, USA |

²⁶

Department of Genetics, Harvard Medical School, Boston, USA |

²⁷

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia |

²⁸

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany |

²⁹

Department of Neuroscience, ICAHN School of Medicine at Mount Sinai, New York, USA |

³⁰

Ronald M. Loeb Center for Alzheimer’s disease, Icahn School of Medicine at Mount Sinai, New York, USA |

³¹

Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA |

³²

deCODE genetics/AMGEN, Reykjavik, Iceland |

³³

Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway |

³⁴

Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea

Sungkyunkwan University

Samsung Medical Center

³⁵

Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation |

³⁶

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany |

³⁷

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany |

³⁸

National Centre for Register-based Research, Aarhus University, Aarhus, Denmark |

³⁹

Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark |

⁴⁰

Division of Psychiatry, University College London, London, UK |

⁴¹

Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

Istituti di Ricovero e Cura a Carattere Scientifico

Mario Negri Institute for Pharmacological Research

⁴²

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA |

⁴³

Northwestern University, Chicago, USA |

⁴⁴

Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK |

⁴⁵

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USA |

⁴⁶

2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece |

⁴⁷

Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea

Sungkyunkwan University

Samsung Medical Center

⁴⁸

Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark |

⁴⁹

Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Technische Universität Dresden

University Hospital Carl Gustav Carus

⁵⁰

Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria |

⁵¹

Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway |

⁵²

Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands |

⁵³

Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red de Salud Mental

⁵⁴

Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain |

⁵⁵

Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain |

⁵⁶

Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain

Autonomous University of Barcelona

Vall d'Hebron Research Institute

⁵⁷

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany |

⁵⁸

Psychiatry, University of California San Francisco, San Francisco, USA |

⁵⁹

University Of Newcastle, Newcastle, Australia |

⁶⁰

Mood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Canada |

⁶¹

Division of Psychiatry, University of Edinburgh, Edinburgh, UK |

⁶²

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany |

⁶³

Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico |

⁶⁴

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, USA |

⁶⁵

Department of laboratory medicine and pathology, Mayo Clinic, Rochester, USA |

⁶⁶

Centre for Psychiatry, Queen Mary University of London, London, UK |

⁶⁷

UCL Genetics Institute, University College London, London, UK |

⁶⁸

Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland |

⁶⁹

Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, USA |

⁷⁰

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany |

⁷¹

Department of medical genetics, Oslo University Hospital, Oslo, Norway |

⁷²

NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway |

⁷³

Department of Neurology, Oslo University Hospital, Oslo, Norway |

⁷⁴

NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway |

⁷⁵

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK |

⁷⁶

Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK |

⁷⁷

Department of Medical and Molecular Genetics, Indiana University, Indianapolis, USA |

⁷⁸

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Heidelberg University

University of Mannheim

Central Institute of Mental Health

⁷⁹

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, USA |

⁸⁰

Department of clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden |

⁸¹

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany |

⁸²

Department of Psychiatry, Dalhousie University, Halifax, Canada |

⁸³

Department of Psychiatry, Yale School of Medicine, New Haven, USA |

⁸⁴

Veterans Affairs Connecticut Healthcare System, West Haven, USA |

⁸⁵

Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, USA |

⁸⁶

Department of Psychological Sciences, University of Missouri, Columbia, USA |

⁸⁷

Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia |

⁸⁸

Psychological Medicine, University of Worcester, Worcester, UK |

⁸⁹

Department of Psychiatry, University of California San Diego, La Jolla, USA |

⁹⁰

Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark |

⁹¹

Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain |

⁹²

Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea |

⁹³

Landspitali University Hospital, Reykjavik, Iceland |

⁹⁴

Department of Psychology, Eberhard Karls Universität Tübingen, Tübingen, Germany |

⁹⁵

Department of Biomedicine, University of Basel, Basel, Switzerland |

⁹⁶

Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland |

⁹⁷

Neuropsychiatrie Translationnelle, Inserm U955, Créteil, France |

⁹⁸

Faculté de Santé, Université Paris Est, Créteil, France |

⁹⁹

International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany |

¹⁰⁰

Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan |

¹⁰¹

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan |

¹⁰²

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada |

¹⁰³

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada |

¹⁰⁴

Department of Psychiatry, University Of Toronto, Toronto, Canada |

¹⁰⁵

Institute of Medical Sciences, University of Toronto, Toronto, Canada |

¹⁰⁶

Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany |

¹⁰⁷

Cell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, USA |

¹⁰⁸

Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, USA |

¹⁰⁹

ISGlobal, Barcelona, Spain |

¹¹⁰

Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece |

¹¹¹

Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, USA |

¹¹²

Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA |

¹¹³

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan |

¹¹⁴

Psychiatry, Altrecht, Utrecht, the Netherlands |

¹¹⁵

Psychiatry, GGZ inGeest, Amsterdam, the Netherlands |

¹¹⁶

Psychiatry, VU Medisch Centrum, Amsterdam, the Netherlands |

¹¹⁷

Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands |

¹¹⁸

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden |

¹¹⁹

Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SWEDEN |

¹²⁰

Psychiatry, North East London NHS Foundation Trust, Ilford, UK |

¹²¹

Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany |

¹²²

Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea |

¹²³

Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Harvard University

Massachusetts General Hospital

¹²⁴

HudsonAlpha Institute for Biotechnology, Huntsville, USA |

¹²⁵

Department of Human Genetics, McGill University, Montréal, Canada |

¹²⁶

Montreal Neurological Institute and Hospital, McGill University, Montréal, Canada

McGill University

Montreal Neurological Institute and Hospital

¹²⁷

Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK |

¹²⁸

Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany |

¹²⁹

Clinical Biochemistry Laboratory, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece |

¹³⁰

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska institutet, Stockholm, Sweden |

¹³¹

Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa |

¹³²

Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France |

¹³³

Department of Psychiatry, Massachusetts General Hospital, Boston, USA |

¹³⁴

Centre for Neuroimaging and Cognitive Genomics (NICOG), National University of Ireland Galway, Galway, Ireland |

¹³⁵

Medical Faculty, School of Science and Technology, University Sarajevo, Sarajevo, Bosnia and Herzegovina |

¹³⁶

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, USA |

¹³⁷

Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK |

¹³⁸

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK |

¹³⁹

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, USA |

¹⁴⁰

Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands |

¹⁴¹

Department of Psychiatry, Washington University in Saint Louis, Saint Louis, USA |

¹⁴²

Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain |

¹⁴³

Institute of Neurosciences, Biomedical Research Center (CIBM), University of Granada, Granada, Spain |

¹⁴⁴

Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, USA |

¹⁴⁵

Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain |

¹⁴⁶

Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland |

¹⁴⁷

Institute of Health and WellBeing, University of Glasgow, Glasgow, UK |

¹⁴⁸

Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, USA |

¹⁴⁹

Mood Disorders, PsyQ, Rotterdam, the Netherlands |

¹⁵⁰

SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa

University of Cape Town

South African Medical Research Council

¹⁵¹

Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland |

¹⁵²

Neuroscience Research Australia, Sydney, Australia |

¹⁵³

School of Medical Sciences, University of New South Wales, Sydney, Australia |

¹⁵⁴

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain

Universidad Autónoma de Madrid

Center for Molecular Biology Severo Ochoa

¹⁵⁵

Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, USA |

¹⁵⁶

Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany |

¹⁵⁷

Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, USA |

¹⁵⁸

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada |

¹⁵⁹

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK |

¹⁶⁰

South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK |

¹⁶¹

Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden |

¹⁶²

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, Norway

University of Oslo

Diakonhjemmet Hospital

¹⁶³

National Institute of Mental Health, Klecany, Czech Republic |

¹⁶⁴

Institute of Environmental Medicine, Karolinska institutet, Stockholm, Sweden |

¹⁶⁵

Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation |

¹⁶⁶

Department of Psychiatry, University of Münster, Münster, Germany |

¹⁶⁷

Department of Psychiatry, Melbourne Medical School, the University of Melbourne, Melbourne, Australia |

¹⁶⁸

The Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Parkville, Australia

University of Melbourne

Florey Institute of Neuroscience and Mental Health

¹⁶⁹

Université de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France |

¹⁷⁰

APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France |

¹⁷¹

Psychiatry, University of Pennsylvania, Philadelphia, USA |

¹⁷²

Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, USA |

¹⁷³

Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark |

¹⁷⁴

Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark |

¹⁷⁵

School of psychiatry, University of New South Wales, Sydney, Australia |

¹⁷⁶

university of Queensland, Brisbane, Australia |

¹⁷⁷

Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland |

¹⁷⁸

1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece |

¹⁷⁹

Medical and Population Genetics, Broad Institute, Cambridge, USA |

¹⁸⁰

Division of Endocrinology, Children’s Hospital Boston, Boston, USA |

¹⁸¹

Department of Human Genetics, university of Chicago, Chicago, USA |

¹⁸²

Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania |

¹⁸³

HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway |

¹⁸⁴

University of Western Australia, NEDLANDS, Australia |

¹⁸⁵

Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden |

¹⁸⁶

Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France |

¹⁸⁷

Department of Medical and Molecular Genetics, King’s College London, London, UK |

¹⁸⁸

Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, USA |

¹⁸⁹

Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland |

¹⁹⁰

SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa |

¹⁹¹

School of Psychology, the University of Queensland, Brisbane, Australia |

¹⁹²

Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, USA |

¹⁹³

Research Institute, Lindner Center of HOPE, Mason, USA |

¹⁹⁴

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK |

¹⁹⁵

Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, USA |

¹⁹⁶

Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway |

¹⁹⁷

Psychiatry, St Olavs University Hospital, Trondheim, Norway |

¹⁹⁸

Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Risskov, Denmark |

¹⁹⁹

Munich Cluster for Systems Neurology (SyNergY), Munich, Germany |

²⁰⁰

University of LIverpool, Liverpool, UK |

²⁰¹

Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, USA |

²⁰²

Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark |

²⁰³

Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway |

²⁰⁴

Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway |

²⁰⁵

Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden

Karolinska Institute

Karolinska University Hospital

²⁰⁶

Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, USA |

²⁰⁷

University Of Melbourne, Melbourne, Australia |

²⁰⁸

Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates |

²⁰⁹

Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates |

²¹⁰

Psychiatry, Harvard Medical School, Boston, USA |

²¹¹

Division of Clinical Research, Massachusetts General Hospital, Boston, USA |

²¹²

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

Vrije Universiteit Amsterdam

Amsterdam Neuroscience

²¹³

Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, The Netherlands

Vrije Universiteit Medical Center

Amsterdam Neuroscience

²¹⁴

Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Canada |

²¹⁵

Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, USA |

²¹⁶

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, ITALY |

²¹⁷

Department of Neuroscience, SUNY Upstate Medical University, Syracuse, USA |

²¹⁸

Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, USA |

²¹⁹

Faculty of medicine, University of Iceland, Reykjavik, Iceland |

²²⁰

Department of psychiatry, Hospital Namsos, Namsos, Norway |

²²¹

Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for Naturvitenskap og Teknologi, Trondheim, Norway |

²²²

Department of Genetics, University of North Carolina At Chapel Hill, Chapel Hill, USA |

²²³

Department of Psychiatry, University of North Carolina At Chapel Hill, Chapel Hill, USA |

²²⁴

Department of psychiatry, McGill University, Montreal, Canada |

²²⁵

Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway |

²²⁶

Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain

Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer

Hospital Clínic de Barcelona

Centro de Investigación Biomédica en Red de Salud Mental

²²⁷

Department of Psychology, Emory University, Atlanta, USA |

²²⁸

Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark |

²²⁹

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark |

²³⁰

Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark |

²³¹

Queensland Brain Institute, the University of Queensland, Brisbane, Australia |

²³²

Psychiatry, Indiana University School of Medicine, Indianapolis, USA |

²³³

Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA |

²³⁴

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA |

Publication type: Journal Article

Publication date: 2021-05-17

Springer Nature

Nature Genetics

scimago Q1

wos Q1

SJR: 16.586

CiteScore: 45.1

Impact factor: 29.0

ISSN: 10614036, 15461718

DOI: 10.1038/s41588-021-00857-4

Copy DOI

PubMed ID: 34002096

Genetics

Abstract

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Found

2 citations

Scholz Sonja

🥼 🤝

114 publications, 3 222 citations, 10 reviews

h-index: 25

National Institute of Neurological Disorders and Stroke

Johns Hopkins University

1 citation

Limborska Svetlana

DSc in Biological/biomedical sciences, professor, associate member of the Russian Academy of Sciences

214 publications, 22 431 citations

h-index: 35

National Research Centre "Kurchatov Institute"

Research interests

Population studies

1 citation

Georgiou Andrea

🥼 🤝

19 publications, 194 citations, 4 reviews

h-index: 10

University of Cyprus

University of Ioannina

Top-30

Journals

	10 20 30 40 50 60 70
Molecular Psychiatry	Molecular Psychiatry, 65, 5.23% Molecular Psychiatry 65 publications, 5.23%
Journal of Affective Disorders	Journal of Affective Disorders, 58, 4.66% Journal of Affective Disorders 58 publications, 4.66%
Translational Psychiatry	Translational Psychiatry, 57, 4.58% Translational Psychiatry 57 publications, 4.58%
medRxiv : the preprint server for health sciences	medRxiv : the preprint server for health sciences, 45, 3.62% medRxiv : the preprint server for health sciences 45 publications, 3.62%
Nature Communications	Nature Communications, 33, 2.65% Nature Communications 33 publications, 2.65%
Biological Psychiatry	Biological Psychiatry, 25, 2.01% Biological Psychiatry 25 publications, 2.01%
Frontiers in Psychiatry	Frontiers in Psychiatry, 23, 1.85% Frontiers in Psychiatry 23 publications, 1.85%
bioRxiv	bioRxiv, 22, 1.77% bioRxiv 22 publications, 1.77%
Psychological Medicine	Psychological Medicine, 17, 1.37% Psychological Medicine 17 publications, 1.37%
Schizophrenia Bulletin	Schizophrenia Bulletin, 15, 1.21% Schizophrenia Bulletin 15 publications, 1.21%
JAMA Psychiatry	JAMA Psychiatry, 14, 1.13% JAMA Psychiatry 14 publications, 1.13%
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 14, 1.13% American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 14 publications, 1.13%
Psychiatry Research	Psychiatry Research, 12, 0.96% Psychiatry Research 12 publications, 0.96%
Biological Psychiatry Global Open Science	Biological Psychiatry Global Open Science, 12, 0.96% Biological Psychiatry Global Open Science 12 publications, 0.96%
Nature Genetics	Nature Genetics, 11, 0.88% Nature Genetics 11 publications, 0.88%
Progress in Neuro-Psychopharmacology and Biological Psychiatry	Progress in Neuro-Psychopharmacology and Biological Psychiatry, 11, 0.88% Progress in Neuro-Psychopharmacology and Biological Psychiatry 11 publications, 0.88%
European Neuropsychopharmacology	European Neuropsychopharmacology, 11, 0.88% European Neuropsychopharmacology 11 publications, 0.88%
BMC Psychiatry	BMC Psychiatry, 11, 0.88% BMC Psychiatry 11 publications, 0.88%
Nature Human Behaviour	Nature Human Behaviour, 10, 0.8% Nature Human Behaviour 10 publications, 0.8%
Nature Neuroscience	Nature Neuroscience, 10, 0.8% Nature Neuroscience 10 publications, 0.8%
Bipolar Disorders	Bipolar Disorders, 10, 0.8% Bipolar Disorders 10 publications, 0.8%
Neuropsychopharmacology	Neuropsychopharmacology, 9, 0.72% Neuropsychopharmacology 9 publications, 0.72%
BMC Medicine	BMC Medicine, 9, 0.72% BMC Medicine 9 publications, 0.72%
American Journal of Psychiatry	American Journal of Psychiatry, 8, 0.64% American Journal of Psychiatry 8 publications, 0.64%
Scientific Reports	Scientific Reports, 8, 0.64% Scientific Reports 8 publications, 0.64%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 8, 0.64% International Journal of Molecular Sciences 8 publications, 0.64%
European Archives of Psychiatry and Clinical Neuroscience	European Archives of Psychiatry and Clinical Neuroscience, 8, 0.64% European Archives of Psychiatry and Clinical Neuroscience 8 publications, 0.64%
Genes	Genes, 7, 0.56% Genes 7 publications, 0.56%
Cell Genomics	Cell Genomics, 7, 0.56% Cell Genomics 7 publications, 0.56%
	10 20 30 40 50 60 70

Publishers

	50 100 150 200 250 300 350
Springer Nature	Springer Nature, 339, 27.25% Springer Nature 339 publications, 27.25%
Elsevier	Elsevier, 273, 21.95% Elsevier 273 publications, 21.95%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 247, 19.86% Cold Spring Harbor Laboratory 247 publications, 19.86%
Wiley	Wiley, 73, 5.87% Wiley 73 publications, 5.87%
Frontiers Media S.A.	Frontiers Media S.A., 41, 3.3% Frontiers Media S.A. 41 publications, 3.3%
MDPI	MDPI, 39, 3.14% MDPI 39 publications, 3.14%
Oxford University Press	Oxford University Press, 36, 2.89% Oxford University Press 36 publications, 2.89%
Cambridge University Press	Cambridge University Press, 24, 1.93% Cambridge University Press 24 publications, 1.93%
American Medical Association (AMA)	American Medical Association (AMA), 15, 1.21% American Medical Association (AMA) 15 publications, 1.21%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 13, 1.05% American Association for the Advancement of Science (AAAS) 13 publications, 1.05%
Research Square Platform LLC	Research Square Platform LLC, 12, 0.96% Research Square Platform LLC 12 publications, 0.96%
Taylor & Francis	Taylor & Francis, 11, 0.88% Taylor & Francis 11 publications, 0.88%
American Psychiatric Association Publishing	American Psychiatric Association Publishing, 9, 0.72% American Psychiatric Association Publishing 9 publications, 0.72%
SAGE	SAGE, 9, 0.72% SAGE 9 publications, 0.72%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 8, 0.64% Ovid Technologies (Wolters Kluwer Health) 8 publications, 0.64%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 7, 0.56% Public Library of Science (PLoS) 7 publications, 0.56%
S. Karger AG	S. Karger AG, 6, 0.48% S. Karger AG 6 publications, 0.48%
BMJ	BMJ, 6, 0.48% BMJ 6 publications, 0.48%
CMA Impact Inc.	CMA Impact Inc., 3, 0.24% CMA Impact Inc. 3 publications, 0.24%
Royal College of Psychiatrists	Royal College of Psychiatrists, 3, 0.24% Royal College of Psychiatrists 3 publications, 0.24%
American Society for Clinical Investigation	American Society for Clinical Investigation, 2, 0.16% American Society for Clinical Investigation 2 publications, 0.16%
eLife Sciences Publications	eLife Sciences Publications, 2, 0.16% eLife Sciences Publications 2 publications, 0.16%
Baishideng Publishing Group	Baishideng Publishing Group, 2, 0.16% Baishideng Publishing Group 2 publications, 0.16%
European Molecular Biology Organization	European Molecular Biology Organization, 1, 0.08% European Molecular Biology Organization 1 publication, 0.08%
American Physiological Society	American Physiological Society, 1, 0.08% American Physiological Society 1 publication, 0.08%
Rockefeller University Press	Rockefeller University Press, 1, 0.08% Rockefeller University Press 1 publication, 0.08%
Eco-Vector LLC	Eco-Vector LLC, 1, 0.08% Eco-Vector LLC 1 publication, 0.08%
Spandidos Publications	Spandidos Publications, 1, 0.08% Spandidos Publications 1 publication, 0.08%
	50 100 150 200 250 300 350

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

1.2k

Cite this

GOST |

Cite this

GOST Copy

Mullins N. et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology // Nature Genetics. 2021. Vol. 53. No. 6. pp. 817-829.

GOST all authors (up to 50) Copy

Mullins N. et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology // Nature Genetics. 2021. Vol. 53. No. 6. pp. 817-829.

RIS |

Cite this

RIS

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Mullins,

author = {Niamh Mullins and Andreas J. Forstner and Kevin S. O'Connell and Brandon Coombes and Jonathan R. I. Coleman and Zhen Qiao and Thomas D. Als and Tim B. Bigdeli and Sigrid Børte and Julien Bryois and Alexander W. Charney and Ole Kristian Drange and Michael J Gandal and Saskia P. Hagenaars and Masashi IKEDA and Nolan Kamitaki and Minsoo Kim and Kristi Krebs and Georgia Panagiotaropoulou and Brian M Schilder and Laura G Sloofman and Stacy Steinberg and Vassily Trubetskoy and Bendik S. Winsvold and HONG-HEE WON and Liliya Abramova and Kristina Adorjan and Esben Agerbo and Mariam Al Eissa and Diego Albani and Ney Alliey-Rodriguez and Adebayo Anjorin and Verneri Antilla and Anastasia Antoniou and Swapnil Awasthi and Ji Hyun Baek and Marie Bækvad-Hansen and Nicholas Bass and Michael Bauer and Eva C Beins and Sarah E. Bergen and Armin Birner and Carsten Bøcker Pedersen and Erlend Bøen and Marco P. Boks and Rosa Bosch and Murielle Brum and Ben M. Brumpton and Nathalie Brunkhorst Kanaan and Monika Budde and others},

title = {Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology},

journal = {Nature Genetics},

year = {2021},

volume = {53},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038/s41588-021-00857-4},

number = {6},

pages = {817--829},

doi = {10.1038/s41588-021-00857-4}

}

MLA

Cite this

MLA Copy

Mullins, Niamh, et al. “Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.” Nature Genetics, vol. 53, no. 6, May. 2021, pp. 817-829. https://doi.org/10.1038/s41588-021-00857-4.

Publisher

Springer Nature

Journal

Nature Genetics

scimago Q1

wos Q1

SJR

16.586

CiteScore

45.1

Impact factor

29.0

ISSN

10614036 (Print)

15461718 (Electronic)