Nature Immunology, volume 25, issue 4, pages 633-643
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Valeria Fumagalli
1, 2
,
Micol Ravà
1, 2
,
Davide Marotta
1, 2
,
Pietro Di Lucia
1, 2
,
Elisa B Bono
1
,
Leonardo Giustini
1
,
Federica De Leo
3
,
Maura Casalgrandi
4
,
Emanuele Monteleone
2
,
Violette Mouro
1
,
Chiara Malpighi
1
,
Chiara Perucchini
1
,
Marta Grillo
1, 2
,
Sara De Palma
1, 5
,
Lorena Donnici
6
,
Silvia Marchese
7
,
Matteo Conti
6
,
Hiromi Muramatsu
8
,
S. Perlman
9, 10
,
Norbert Pardi
8
,
Mirela Kuka
1, 2
,
Raffaele De Francesco
6, 7
,
Marco E Bianchi
2, 3
,
Luca G. Guidotti
1, 2
,
Matteo Iannacone
1, 2, 11
4
HMGBiotech, Milan, Italy
|
5
Charles River Laboratories, Calco, Italy
|
6
Istituto Nazionale di Genetica Molecolare (INGM) ‘Romeo ed Enrica Invernizzi’, Milan, Italy
|
9
Department of Microbiology and Immunology, University of Iowa, Iowa City, USA
|
10
Department of Pediatrics, University of Iowa, Iowa city, USA
|
Publication type: Journal Article
Publication date: 2024-03-14
Journal:
Nature Immunology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 30.5
ISSN: 15292908, 15292916
Immunology
Immunology and Allergy
Abstract
Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies. Our findings, using three distinct models inclusive of a novel human/mouse ACE2 hybrid, highlight that CD8+ T cells are essential for combating severe infections, whereas CD4+ T cells contribute to managing milder cases, with interferon-γ having an important function in this antibody-independent defense. These findings highlight the importance of T cell responses in vaccine development, urging a broader perspective on protective immunity beyond just antibodies.
Top-30
Citations by journals
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1
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Nature Immunology
1 publication, 14.29%
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Nature Microbiology
1 publication, 14.29%
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Frontiers in Immunology
1 publication, 14.29%
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Advanced Science
1 publication, 14.29%
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Russian Chemical Reviews
1 publication, 14.29%
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Immunity
1 publication, 14.29%
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EBioMedicine
1 publication, 14.29%
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1
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Citations by publishers
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1
2
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Springer Nature
2 publications, 28.57%
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Elsevier
2 publications, 28.57%
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Frontiers Media S.A.
1 publication, 14.29%
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Wiley
1 publication, 14.29%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 14.29%
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1
2
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fumagalli V. et al. Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination // Nature Immunology. 2024. Vol. 25. No. 4. pp. 633-643.
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Fumagalli V. et al. Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination // Nature Immunology. 2024. Vol. 25. No. 4. pp. 633-643.
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TY - JOUR
DO - 10.1038/s41590-024-01787-z
UR - https://doi.org/10.1038/s41590-024-01787-z
TI - Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
T2 - Nature Immunology
AU - Fumagalli, Valeria
AU - Ravà, Micol
AU - Marotta, Davide
AU - Di Lucia, Pietro
AU - Bono, Elisa B
AU - Giustini, Leonardo
AU - De Leo, Federica
AU - Casalgrandi, Maura
AU - Monteleone, Emanuele
AU - Mouro, Violette
AU - Malpighi, Chiara
AU - Perucchini, Chiara
AU - Grillo, Marta
AU - De Palma, Sara
AU - Donnici, Lorena
AU - Marchese, Silvia
AU - Conti, Matteo
AU - Muramatsu, Hiromi
AU - Perlman, S.
AU - Pardi, Norbert
AU - Kuka, Mirela
AU - De Francesco, Raffaele
AU - Bianchi, Marco E
AU - Guidotti, Luca G.
AU - Iannacone, Matteo
PY - 2024
DA - 2024/03/14 00:00:00
PB - Springer Nature
SP - 633-643
IS - 4
VL - 25
SN - 1529-2908
SN - 1529-2916
ER -
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@article{2024_Fumagalli,
author = {Valeria Fumagalli and Micol Ravà and Davide Marotta and Pietro Di Lucia and Elisa B Bono and Leonardo Giustini and Federica De Leo and Maura Casalgrandi and Emanuele Monteleone and Violette Mouro and Chiara Malpighi and Chiara Perucchini and Marta Grillo and Sara De Palma and Lorena Donnici and Silvia Marchese and Matteo Conti and Hiromi Muramatsu and S. Perlman and Norbert Pardi and Mirela Kuka and Raffaele De Francesco and Marco E Bianchi and Luca G. Guidotti and Matteo Iannacone},
title = {Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination},
journal = {Nature Immunology},
year = {2024},
volume = {25},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038/s41590-024-01787-z},
number = {4},
pages = {633--643},
doi = {10.1038/s41590-024-01787-z}
}
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Fumagalli, Valeria, et al. “Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination.” Nature Immunology, vol. 25, no. 4, Mar. 2024, pp. 633-643. https://doi.org/10.1038/s41590-024-01787-z.
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