Open Access

Scientific Reports, volume 7, issue 1, publication number 12509

Pore formation in lipid membrane II: Energy landscape under external stress

Akimov Sergey A ^{1, 2}

Volynsky Pavel E ³

Galimzyanov Timur R ^{1, 2}

Kuzmin Peter I ¹

Pavlov Konstantin V ^{1, 4}

Batishchev Oleg ^{1, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of sciences, Moscow, Russia |

National University of Science and technology “MISiS”, Moscow, Russia |

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia |

⁴

Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia |

⁵

Moscow Institute of Physics and Technology, Dolgoprudniy, Russia |

Publication type: Journal Article

Publication date: 2017-10-02

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-017-12749-x

Copy DOI

PubMed ID: 28970526

Multidisciplinary

Abstract

Lipid membranes are extremely stable envelopes allowing cells to survive in various environments and to maintain desired internal composition. Membrane permeation through formation of transversal pores requires substantial external stress. Practically, pores are usually formed by application of lateral tension or transmembrane voltage. Using the same approach as was used for obtaining continuous trajectory of pore formation in the stress-less membrane in the previous article, we now consider the process of pore formation under the external stress. The waiting time to pore formation proved a non-monotonous function of the lateral tension, dropping from infinity at zero tension to a minimum at the tension of several millinewtons per meter. Transmembrane voltage, on the contrary, caused the waiting time to decrease monotonously. Analysis of pore formation trajectories for several lipid species with different spontaneous curvatures and elastic moduli under various external conditions provided instrumental insights into the mechanisms underlying some experimentally observed phenomena.

By date By citations

Citations by journals

	1 2 3 4 5 6 7
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 7, 10.29% Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 7 publications, 10.29%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 5.88% International Journal of Molecular Sciences 4 publications, 5.88%
Physical Review E	Physical Review E, 3, 4.41% Physical Review E 3 publications, 4.41%
European Biophysics Journal	European Biophysics Journal, 3, 4.41% European Biophysics Journal 3 publications, 4.41%
Soft Matter	Soft Matter, 3, 4.41% Soft Matter 3 publications, 4.41%
Journal of Membrane Biology	Journal of Membrane Biology, 2, 2.94% Journal of Membrane Biology 2 publications, 2.94%
Biochimica et Biophysica Acta - Biomembranes	Biochimica et Biophysica Acta - Biomembranes, 2, 2.94% Biochimica et Biophysica Acta - Biomembranes 2 publications, 2.94%
PLoS ONE	PLoS ONE, 2, 2.94% PLoS ONE 2 publications, 2.94%
Langmuir	Langmuir, 2, 2.94% Langmuir 2 publications, 2.94%
Physics of Fluids	Physics of Fluids, 1, 1.47% Physics of Fluids 1 publication, 1.47%
Journal of Applied Physics	Journal of Applied Physics, 1, 1.47% Journal of Applied Physics 1 publication, 1.47%
Physical Review Letters	Physical Review Letters, 1, 1.47% Physical Review Letters 1 publication, 1.47%
Current Drug Delivery	Current Drug Delivery, 1, 1.47% Current Drug Delivery 1 publication, 1.47%
Journal of Cell Science	Journal of Cell Science, 1, 1.47% Journal of Cell Science 1 publication, 1.47%
Journal of the Royal Society Interface	Journal of the Royal Society Interface, 1, 1.47% Journal of the Royal Society Interface 1 publication, 1.47%
Royal Society Open Science	Royal Society Open Science, 1, 1.47% Royal Society Open Science 1 publication, 1.47%
Biomolecules	Biomolecules, 1, 1.47% Biomolecules 1 publication, 1.47%
Membranes	Membranes, 1, 1.47% Membranes 1 publication, 1.47%
Processes	Processes, 1, 1.47% Processes 1 publication, 1.47%
Molecules	Molecules, 1, 1.47% Molecules 1 publication, 1.47%
Biomechanics and Modeling in Mechanobiology	Biomechanics and Modeling in Mechanobiology, 1, 1.47% Biomechanics and Modeling in Mechanobiology 1 publication, 1.47%
Biophysical Reviews	Biophysical Reviews, 1, 1.47% Biophysical Reviews 1 publication, 1.47%
Scientific Reports	Scientific Reports, 1, 1.47% Scientific Reports 1 publication, 1.47%
Bioelectrochemistry	Bioelectrochemistry, 1, 1.47% Bioelectrochemistry 1 publication, 1.47%
Journal Physics D: Applied Physics	Journal Physics D: Applied Physics, 1, 1.47% Journal Physics D: Applied Physics 1 publication, 1.47%
Chemistry and Physics of Lipids	Chemistry and Physics of Lipids, 1, 1.47% Chemistry and Physics of Lipids 1 publication, 1.47%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 1, 1.47% Biosensors and Bioelectronics 1 publication, 1.47%
Journal of Colloid and Interface Science	Journal of Colloid and Interface Science, 1, 1.47% Journal of Colloid and Interface Science 1 publication, 1.47%
Biophysical Journal	Biophysical Journal, 1, 1.47% Biophysical Journal 1 publication, 1.47%
	1 2 3 4 5 6 7

Citations by publishers

	2 4 6 8 10
Springer Nature	Springer Nature, 10, 14.71% Springer Nature 10 publications, 14.71%
Pleiades Publishing	Pleiades Publishing, 9, 13.24% Pleiades Publishing 9 publications, 13.24%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 8, 11.76% Multidisciplinary Digital Publishing Institute (MDPI) 8 publications, 11.76%
American Chemical Society (ACS)	American Chemical Society (ACS), 8, 11.76% American Chemical Society (ACS) 8 publications, 11.76%
Elsevier	Elsevier, 6, 8.82% Elsevier 6 publications, 8.82%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 5, 7.35% Royal Society of Chemistry (RSC) 5 publications, 7.35%
American Physical Society (APS)	American Physical Society (APS), 4, 5.88% American Physical Society (APS) 4 publications, 5.88%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 3, 4.41% American Institute of Physics (AIP) 3 publications, 4.41%
The Royal Society	The Royal Society, 2, 2.94% The Royal Society 2 publications, 2.94%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 2.94% Public Library of Science (PLoS) 2 publications, 2.94%
Wiley	Wiley, 2, 2.94% Wiley 2 publications, 2.94%
Bentham Science	Bentham Science, 1, 1.47% Bentham Science 1 publication, 1.47%
The Company of Biologists	The Company of Biologists, 1, 1.47% The Company of Biologists 1 publication, 1.47%
IOP Publishing	IOP Publishing, 1, 1.47% IOP Publishing 1 publication, 1.47%
Biophysical Society	Biophysical Society, 1, 1.47% Biophysical Society 1 publication, 1.47%
Akademie Ved Ceske Republiky	Akademie Ved Ceske Republiky, 1, 1.47% Akademie Ved Ceske Republiky 1 publication, 1.47%
Taylor & Francis	Taylor & Francis, 1, 1.47% Taylor & Francis 1 publication, 1.47%
	2 4 6 8 10

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","",""],"datasets":[{"label":"Citations number","data":[1,6,14,18,13,8,7,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["1.47","8.82","20.59","26.47","19.12","11.76","10.29","1.47"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology","International Journal of Molecular Sciences","Physical Review E","European Biophysics Journal","Soft Matter","Journal of Membrane Biology","Biochimica et Biophysica Acta - Biomembranes","PLoS ONE","Langmuir","Physics of Fluids","Journal of Applied Physics","Physical Review Letters","Current Drug Delivery","Journal of Cell Science","Journal of the Royal Society Interface","Royal Society Open Science","Biomolecules","Membranes","Processes","Molecules","Biomechanics and Modeling in Mechanobiology","Biophysical Reviews","Scientific Reports","Bioelectrochemistry","Journal Physics D: Applied Physics","Chemistry and Physics of Lipids","Biosensors and Bioelectronics","Journal of Colloid and Interface Science","Biophysical Journal"],"ids":[6012,14627,12743,6317,15507,5272,24807,24963,19601,14994,11951,4343,2705,21886,13195,3859,13780,6479,19796,1770,8166,79,13767,17177,14873,22265,18799,24202,4026],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/nrK64iXHTzj43wMrfN1ZoUQ0vanswGzWPN45K3jA_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/nrK64iXHTzj43wMrfN1ZoUQ0vanswGzWPN45K3jA_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/Bmz9XNb2QDptmPTa5N8huM54tShVewUj8fZqKFRy_medium.webp"],"datasets":[{"label":"","data":[7,4,3,3,3,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[10.29,5.88,4.41,4.41,4.41,2.94,2.94,2.94,2.94,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47,1.47],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Pleiades Publishing","Multidisciplinary Digital Publishing Institute (MDPI)","American Chemical Society (ACS)","Elsevier","Royal Society of Chemistry (RSC)","American Physical Society (APS)","American Institute of Physics (AIP)","The Royal Society","Public Library of Science (PLoS)","Wiley","Bentham Science","The Company of Biologists","IOP Publishing","Biophysical Society","Akademie Ved Ceske Republiky","Taylor & Francis"],"ids":[8,101,202,40,17,123,1539,250,259,344,11,39,872,2075,1454,128,18],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/nrK64iXHTzj43wMrfN1ZoUQ0vanswGzWPN45K3jA_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/ko5EaisKGm66J1hHXtfEgVEeeWb9uOcMofpNuf0a_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/Bmz9XNb2QDptmPTa5N8huM54tShVewUj8fZqKFRy_medium.webp","","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp"],"datasets":[{"label":"","data":[10,9,8,8,6,5,4,3,2,2,2,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.71,13.24,11.76,11.76,8.82,7.35,5.88,4.41,2.94,2.94,2.94,1.47,1.47,1.47,1.47,1.47,1.47],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Akimov S. A. et al. Pore formation in lipid membrane II: Energy landscape under external stress // Scientific Reports. 2017. Vol. 7. No. 1. 12509

GOST all authors (up to 50) Copy

Akimov S. A., Volynsky P. E., Galimzyanov T. R., Kuzmin P. I., Pavlov K. V., Batishchev O. Pore formation in lipid membrane II: Energy landscape under external stress // Scientific Reports. 2017. Vol. 7. No. 1. 12509

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/s41598-017-12749-x

UR - https://doi.org/10.1038%2Fs41598-017-12749-x

TI - Pore formation in lipid membrane II: Energy landscape under external stress

T2 - Scientific Reports

AU - Akimov, Sergey A

AU - Volynsky, Pavel E

AU - Galimzyanov, Timur R

AU - Kuzmin, Peter I

AU - Pavlov, Konstantin V

AU - Batishchev, Oleg

PY - 2017

DA - 2017/10/02 00:00:00

PB - Springer Nature

IS - 1

VL - 7

PMID - 28970526

SN - 2045-2322

ER -

BibTex

Cite this

BibTex Copy

@article{2017_Akimov,

author = {Sergey A Akimov and Pavel E Volynsky and Timur R Galimzyanov and Peter I Kuzmin and Konstantin V Pavlov and Oleg Batishchev},

title = {Pore formation in lipid membrane II: Energy landscape under external stress},

journal = {Scientific Reports},

year = {2017},

volume = {7},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1038%2Fs41598-017-12749-x},

number = {1},

doi = {10.1038/s41598-017-12749-x}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Bioelectrochemistry Laboratory

Profiles

Batishchev, Oleg Vyacheslavovich