Open Access
Open access
Springer Nature
Scientific Reports
,  volume 8 ,  issue 1 ,  publication number 4513

High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway

Publication type: Journal Article
Publication date: 2018-03-14
Springer Nature
scimago Q1
wos Q1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
Multidisciplinary
Abstract
High-mobility group box 1 (HMGB1) facilitates neural stem cells (NSCs) proliferation and differentiation into neuronal linage. However, the effect of HMGB1 on NSCs migration is still elusive. The present study is to investigate the corelation between HMGB1 and NSCs migration and the potential mechanism. The results indicated that 1 ng/ml HMGB1 promoted NSCs proliferation using CCK8 assays. Moreover, data showed that 1 ng/ml HMGB1 facilitated NSCs migration via filopodia formation using phase-contrast and transwell assays. Furthermore, 1 ng/ml HMGB1 upregulated the expression of RAGE, one of the HMGB1 receptor, using western blotting assays and immunofluorescence staining. In addition, 1 ng/ml HMGB1 increased the percentage of filopodia formation using phalloidin staining. Meanwhile, the enhanced migration effect could be abrogated by 50 nM FPS-ZM1, one of the RAGE antagonist, and RAGE-specific siRNA through immunofluorescence and phalloidin staining. Together, our data demonstrate that HMGB1/RAGE axis facilitates NSCs migration via promoting filopodia formation, which might serve as a candidate for central nervous system (CNS) injury treatment and/or a preconditioning method for NSCs implantation.
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GOST |
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GOST Copy
Xin X. et al. High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway // Scientific Reports. 2018. Vol. 8. No. 1. 4513
GOST all authors (up to 50) Copy
Xin X., Chen X., Fan W., Wang G., Zhang L., Chen Z., Liu P., Liu M., Zhao J. High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway // Scientific Reports. 2018. Vol. 8. No. 1. 4513
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41598-018-22672-4
UR - https://doi.org/10.1038/s41598-018-22672-4
TI - High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway
T2 - Scientific Reports
AU - Xin, Xue
AU - Chen, Xingxing
AU - Fan, Weili
AU - Wang, Guan
AU - Zhang, Liang
AU - Chen, Zongfeng
AU - Liu, Peng
AU - Liu, Mingyong
AU - Zhao, Jianhua
PY - 2018
DA - 2018/03/14
PB - Springer Nature
IS - 1
VL - 8
PMID - 29540727
SN - 2045-2322
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Xin,
author = {Xue Xin and Xingxing Chen and Weili Fan and Guan Wang and Liang Zhang and Zongfeng Chen and Peng Liu and Mingyong Liu and Jianhua Zhao},
title = {High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway},
journal = {Scientific Reports},
year = {2018},
volume = {8},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038/s41598-018-22672-4},
number = {1},
pages = {4513},
doi = {10.1038/s41598-018-22672-4}
}