Open Access

Scientific Reports

, volume 10 , issue 1 , publication number 508

Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

A N Moiseeva ¹

R. A. Aliev ^{1, 2}

V N Unezhev ¹

V A Zagryadskiy ¹

S T Latushkin ¹

N. V. Aksenov ³

N S Gustova ³

M G Voronuk ³

G. Ya. Starodub ³

A. A. Ogloblin ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

National research center “Kurchatov Institute”, Moscow, Russia |

Chemistry department, Moscow State University, Moscow, Russia |

Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Dubna, Russia |

Publication type: Journal Article

Publication date: 2020-01-16

Springer Nature

Scientific Reports

scimago Q1

wos Q1

SJR: 0.874

CiteScore: 6.7

Impact factor: 3.9

ISSN: 20452322

DOI: 10.1038/s41598-020-57436-6

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PubMed ID: 31949230

Multidisciplinary

Abstract

Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield of 149Tb is 39 MBq/μAh, or 230 MBq/μA 149Tb at saturation. The optimal energy range from the point of view of radioisotopic purity is 70 → 40 MeV. At these conditions about 150 MBq/μA 149Tb can be produced in 8 hours irradiation, which is sufficient for therapeutic applications. The main impurities are 150Tb (~100% in activity) and 151Tb (~30% in activity). The proposed method surpasses its counterparts by the high content of the target isotope in the natural mixture and the simplicity of the radiochemical separation of 149Tb from the bulk target material.

Found

1 citation

Konevega Andrey

🥼 🤝

PhD in Physics and Mathematics

97 publications, 3 395 citations

h-index: 29

Peter the Great St. Petersburg Polytechnic University

National Research Centre "Kurchatov Institute"

Petersburg Nuclear Physics Institute of NRC «Kurchatov Institute»

Research interests

Antibiotics

Nuclear medicine

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Moiseeva A. N. et al. Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production // Scientific Reports. 2020. Vol. 10. No. 1. 508

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Moiseeva A. N., Aliev R. A., Unezhev V. N., Zagryadskiy V. A., Latushkin S. T., Aksenov N. V., Gustova N. S., Voronuk M. G., Starodub G. Y., Ogloblin A. A. Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production // Scientific Reports. 2020. Vol. 10. No. 1. 508

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-020-57436-6

UR - https://doi.org/10.1038/s41598-020-57436-6

TI - Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

T2 - Scientific Reports

AU - Moiseeva, A N

AU - Aliev, R. A.

AU - Unezhev, V N

AU - Zagryadskiy, V A

AU - Latushkin, S T

AU - Aksenov, N. V.

AU - Gustova, N S

AU - Voronuk, M G

AU - Starodub, G. Ya.

AU - Ogloblin, A. A.

PY - 2020

DA - 2020/01/16

PB - Springer Nature

IS - 1

VL - 10

PMID - 31949230

SN - 2045-2322

ER -

BibTex

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BibTex (up to 50 authors) Copy

@article{2020_Moiseeva,

author = {A N Moiseeva and R. A. Aliev and V N Unezhev and V A Zagryadskiy and S T Latushkin and N. V. Aksenov and N S Gustova and M G Voronuk and G. Ya. Starodub and A. A. Ogloblin},

title = {Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production},

journal = {Scientific Reports},

year = {2020},

volume = {10},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038/s41598-020-57436-6},

number = {1},

pages = {508},

doi = {10.1038/s41598-020-57436-6}

}

Publisher

Springer Nature

Journal

Scientific Reports

scimago Q1

wos Q1

SJR

0.874

CiteScore

6.7

Impact factor

3.9

ISSN

20452322 (Print, Electronic)

Labs

Laboratory of Radionuclides and Radiopharmaceuticals

Profiles

Ramiz A Aliev