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Scientific Reports, volume 13, issue 1, publication number 1341

Experimental validation of proton boron capture therapy for glioma cells

Shtam Tatiana ^{1, 2, 3}

Burdakov Vladimir ^{1, 2}

Garina Alina ^{1, 2, 4}

Garaeva Luiza ^{1, 2, 4}

Tran Nhan Hau ^{2, 4}

Volnitskiy Andrey ^{1, 2}

Kuus Eva ^{2, 4, 5}

Amerkanov Dmitry ^{1, 2}

Pack Fedor ^{1, 2}

Andreev Georgy ⁵

Lubinskiy Andrey ⁵

Shabalin Konstantin ^{1, 2}

Verlov Nicolay ^{1, 2}

Ivanov Evgeniy ²

Ezhov Victor ²

Lebedev Dmitry ^{1, 2}

Konevega Andrey L. ^{1, 2, 4}

Hide authors affiliations Show authors affiliations: 5 affiliations

National Research Center “Kurchatov Institute”, Moscow, Russian Federation |

Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre “Kurchatov Institute”, Gatchina, Russian Federation

National Research Centre "Kurchatov Institute"

Petersburg Nuclear Physics Institute of NRC «Kurchatov Institute»

Institute of Cytology of Russian Academy of Sciences, St. Petersburg, Russian Federation |

⁴

Peter the Great St.Petersburg Polytechnic University, St. Petersburg, Russian Federation |

⁵

Proton Therapy Center MIBS, St. Petersburg, Russian Federation |

Publication type: Journal Article

Publication date: 2023-01-24

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-023-28428-z

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PubMed ID: 36693879

Multidisciplinary

Abstract

Proton boron capture therapy (PBCT) has emerged from particle acceleration research for enhancing the biological effectiveness of proton therapy. The mechanism responsible for the dose increase was supposed to be related to proton-boron fusion reactions (¹¹B + p → 3α + 8.7 MeV). There has been some experimental evidence that the biological efficiency of protons is significantly higher for boron-11-containing prostate or breast cancer cells. The aim of this study was to evaluate the sensitizing potential of sodium borocaptate (BSH) under proton irradiation at the Bragg peak of cultured glioma cells. To address this problem, cells of two glioma lines were preincubated with 80 or 160 ppm boron-11, irradiated both at the middle of 200 MeV beam Spread-Out Bragg Peak (SOBP) and at the distal end of the 89.7 MeV beam SOBP and assessed for the viability, as well as their ability to form colonies. Our results clearly show that BSH provides for only a slight, if any, enhancement of the effect of proton radiation on the glioma cells in vitro. In addition, we repeated the experiments using the Du145 prostate cancer cell line, for which an increase in the biological efficiency of proton irradiation in the presence of sodium borocaptate was demonstrated previously. The data presented add new argument against the efficiency of proton boron capture therapy when based solely on direct dose-enhancement effect by the proton capture nuclear reaction, underlining the need to investigate the indirect effects of the secondary alpha irradiation depending on the state and treatment conditions of the irradiated tissue.

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	1
Biomedicines	Biomedicines, 1, 25% Biomedicines 1 publication, 25%
Nanomaterials	Nanomaterials, 1, 25% Nanomaterials 1 publication, 25%
Radiation Physics and Chemistry	Radiation Physics and Chemistry, 1, 25% Radiation Physics and Chemistry 1 publication, 25%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 25% International Journal of Molecular Sciences 1 publication, 25%
	1

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	1 2 3
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 75% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 75%
Elsevier	Elsevier, 1, 25% Elsevier 1 publication, 25%
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Shtam T. et al. Experimental validation of proton boron capture therapy for glioma cells // Scientific Reports. 2023. Vol. 13. No. 1. 1341

GOST all authors (up to 50) Copy

Shtam T., Burdakov V., Garina A., Garaeva L., Tran N. H., Volnitskiy A., Kuus E., Amerkanov D., Pack F., Andreev G., Lubinskiy A., Shabalin K., Verlov N., Ivanov E., Ezhov V., Lebedev D., Konevega A. L. Experimental validation of proton boron capture therapy for glioma cells // Scientific Reports. 2023. Vol. 13. No. 1. 1341

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TY - JOUR

DO - 10.1038/s41598-023-28428-z

UR - https://doi.org/10.1038%2Fs41598-023-28428-z

TI - Experimental validation of proton boron capture therapy for glioma cells

T2 - Scientific Reports

AU - Shtam, Tatiana

AU - Burdakov, Vladimir

AU - Garina, Alina

AU - Garaeva, Luiza

AU - Tran, Nhan Hau

AU - Volnitskiy, Andrey

AU - Kuus, Eva

AU - Amerkanov, Dmitry

AU - Pack, Fedor

AU - Andreev, Georgy

AU - Lubinskiy, Andrey

AU - Shabalin, Konstantin

AU - Verlov, Nicolay

AU - Ivanov, Evgeniy

AU - Ezhov, Victor

AU - Lebedev, Dmitry

AU - Konevega, Andrey L.

PY - 2023

DA - 2023/01/24 00:00:00

PB - Springer Nature

IS - 1

VL - 13

PMID - 36693879

SN - 2045-2322

ER -

BibTex

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@article{2023_Shtam,

author = {Tatiana Shtam and Vladimir Burdakov and Alina Garina and Luiza Garaeva and Nhan Hau Tran and Andrey Volnitskiy and Eva Kuus and Dmitry Amerkanov and Fedor Pack and Georgy Andreev and Andrey Lubinskiy and Konstantin Shabalin and Nicolay Verlov and Evgeniy Ivanov and Victor Ezhov and Dmitry Lebedev and Andrey L. Konevega},

title = {Experimental validation of proton boron capture therapy for glioma cells},

journal = {Scientific Reports},

year = {2023},

volume = {13},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038%2Fs41598-023-28428-z},

number = {1},

doi = {10.1038/s41598-023-28428-z}

}

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Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

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Kuus, Eva Andreevna