Open Access
Nature Communications, volume 12, issue 1, publication number 288
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
CHEOLMIN KIM
1
,
Dong Kyun Ryu
1
,
Ji-Hun Lee
1
,
Young Il Kim
2
,
Ji-Min Seo
1
,
Yeon-Gil Kim
3
,
Jae-Hee Jeong
3
,
Minsoo Kim
1
,
Jong-In Kim
1
,
Pankyeom Kim
1
,
Jin Soo Bae
1
,
Eun Yeong Shim
1
,
Min Seob Lee
1
,
Man Su Kim
1
,
Hanmi Noh
1
,
Geun-Soo Park
1
,
Jae Sang Park
1
,
Dain Son
1
,
Yongjin An
1
,
Jeong-No Lee
1
,
Ki Sung Kwon
1
,
Joo-Yeon Lee
4
,
Hansaem Lee
4
,
Jeong Sun Yang
4
,
Kyung-Chang Kim
4
,
Sung Soon Kim
4
,
Hye Min Woo
4
,
Jun Won Kim
4
,
Man‐Seong Park
5
,
Kwang Min Yu
2
,
Se Mi Kim
2
,
Eun-Ha Kim
2
,
Su Jin Park
2, 6
,
Seong Tae Jeong
7
,
Chi Ho Yu
7
,
YoungJo Song
7
,
Se Hun Gu
7
,
Hanseul Oh
8
,
Bon-Sang Koo
8
,
Jung Joo Hong
8
,
Choong-Min Ryu
9
,
Wan Beom Park
10
,
Myoung-don Oh
10
,
Young Ki Choi
2
,
Soo Young Lee
1
1
Biotechnology Research Institute, Celltrion Inc, Incheon, Republic of Korea
|
4
Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea
|
Publication type: Journal Article
Publication date: 2021-01-12
Journal:
Nature Communications
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 20411723, 20411723
General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy
Abstract
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient. The CT-P59 mAb potently neutralizes SARS-CoV-2 isolates including the D614G variant without antibody-dependent enhancement effect. Complex crystal structure of CT-P59 Fab/RBD shows that CT-P59 blocks interaction regions of RBD for angiotensin converting enzyme 2 (ACE2) receptor with an orientation that is notably different from previously reported RBD-targeting mAbs. Furthermore, therapeutic effects of CT-P59 are evaluated in three animal models (ferret, hamster, and rhesus monkey), demonstrating a substantial reduction in viral titer along with alleviation of clinical symptoms. Therefore, CT-P59 may be a promising therapeutic candidate for COVID-19. Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models.
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Citations by publishers
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Springer Nature
35 publications, 16.43%
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Taylor & Francis
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The American Association of Immunologists
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1 publication, 0.47%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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KIM C. et al. A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein // Nature Communications. 2021. Vol. 12. No. 1. 288
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KIM C., Ryu D. K., Lee J., Kim Y. I., Seo J., Kim Y., Jeong J., Kim M., Kim J., Kim P., Bae J. S., Shim E. Y., Lee M. S., Kim M. S., Noh H., Park G., Park J. S., Son D., An Y., Lee J., Kwon K. S., Lee J., Lee H., Yang J. S., Kim K., Kim S. S., Woo H. M., Kim J. W., Park M., Yu K. M., Kim S. M., Kim E., Park S. J., Jeong S. T., Yu C. H., Song Y., Gu S. H., Oh H., Koo B., Hong J. J., Ryu C., Park W. B., Oh M., Choi Y. K., Lee S. Y. A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein // Nature Communications. 2021. Vol. 12. No. 1. 288
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TY - JOUR
DO - 10.1038/s41467-020-20602-5
UR - https://doi.org/10.1038/s41467-020-20602-5
TI - A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
T2 - Nature Communications
AU - KIM, CHEOLMIN
AU - Ryu, Dong Kyun
AU - Lee, Ji-Hun
AU - Kim, Young Il
AU - Seo, Ji-Min
AU - Kim, Yeon-Gil
AU - Jeong, Jae-Hee
AU - Kim, Minsoo
AU - Kim, Jong-In
AU - Kim, Pankyeom
AU - Bae, Jin Soo
AU - Shim, Eun Yeong
AU - Lee, Min Seob
AU - Kim, Man Su
AU - Noh, Hanmi
AU - Park, Geun-Soo
AU - Park, Jae Sang
AU - Son, Dain
AU - An, Yongjin
AU - Lee, Jeong-No
AU - Kwon, Ki Sung
AU - Lee, Joo-Yeon
AU - Lee, Hansaem
AU - Yang, Jeong Sun
AU - Kim, Kyung-Chang
AU - Kim, Sung Soon
AU - Woo, Hye Min
AU - Kim, Jun Won
AU - Park, Man‐Seong
AU - Yu, Kwang Min
AU - Kim, Se Mi
AU - Kim, Eun-Ha
AU - Park, Su Jin
AU - Jeong, Seong Tae
AU - Yu, Chi Ho
AU - Song, YoungJo
AU - Gu, Se Hun
AU - Oh, Hanseul
AU - Koo, Bon-Sang
AU - Hong, Jung Joo
AU - Ryu, Choong-Min
AU - Park, Wan Beom
AU - Oh, Myoung-don
AU - Choi, Young Ki
AU - Lee, Soo Young
PY - 2021
DA - 2021/01/12 00:00:00
PB - Springer Nature
IS - 1
VL - 12
SN - 2041-1723
SN - 2041-1723
ER -
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@article{2021_KIM,
author = {CHEOLMIN KIM and Dong Kyun Ryu and Ji-Hun Lee and Young Il Kim and Ji-Min Seo and Yeon-Gil Kim and Jae-Hee Jeong and Minsoo Kim and Jong-In Kim and Pankyeom Kim and Jin Soo Bae and Eun Yeong Shim and Min Seob Lee and Man Su Kim and Hanmi Noh and Geun-Soo Park and Jae Sang Park and Dain Son and Yongjin An and Jeong-No Lee and Ki Sung Kwon and Joo-Yeon Lee and Hansaem Lee and Jeong Sun Yang and Kyung-Chang Kim and Sung Soon Kim and Hye Min Woo and Jun Won Kim and Man‐Seong Park and Kwang Min Yu and Se Mi Kim and Eun-Ha Kim and Su Jin Park and Seong Tae Jeong and Chi Ho Yu and YoungJo Song and Se Hun Gu and Hanseul Oh and Bon-Sang Koo and Jung Joo Hong and Choong-Min Ryu and Wan Beom Park and Myoung-don Oh and Young Ki Choi and Soo Young Lee},
title = {A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein},
journal = {Nature Communications},
year = {2021},
volume = {12},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038/s41467-020-20602-5},
number = {1},
doi = {10.1038/s41467-020-20602-5}
}