Nature Medicine, volume 26, issue 9, pages 1422-1427

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Seth J. Zost ¹

Pavlo Gilchuk ¹

Rita E. Chen ^{2, 3}

James Brett Case ³

Joseph X Reidy ¹

Andrew Trivette ¹

Rachel S. Nargi ¹

Rachel E. Sutton ¹

Naveenchandra Suryadevara ¹

Elaine C. Chen ⁴

Elad Binshtein ¹

Swathi Shrihari ³

Mario Ostrowski ⁵

Helen Y. Chu ⁶

Jonathan E. Didier ⁷

Keith W MacRenaris ⁷

Taylor Jones ¹

Samuel Day ¹

Luke Myers ¹

F. Eun-Hyung Lee ⁸

Doan C. Nguyen ⁸

Ignacio Sanz ⁸

David R. Martinez ⁹

Paul W Rothlauf ^{10, 11}

Louis Marie Bloyet ¹¹

Sean Whelan ^{10, 11}

Ralph S Baric ⁹

Larissa B Thackray ³

Michael S. Diamond ^{2, 3, 11, 12}

Robert H. Carnahan ^{1, 13}

James Crowe ^{1, 4, 13}

Hide authors affiliations Show authors affiliations: 13 affiliations

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, USA |

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, USA |

Department of Medicine, Washington University School of Medicine, St. Louis, USA |

⁴

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, USA |

⁵

Department of Medicine, University of Toronto, Toronto, CANADA |

⁶

Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA |

⁷

Berkeley Lights, Inc., Emeryville, USA |

⁸

Department of Medicine, Emory University, Atlanta, USA |

⁹

Department of Epidemiology, University of North Carolina At Chapel Hill, Chapel Hill, USA |

¹⁰

Program in Virology, Harvard Medical School, Boston, USA |

¹¹

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, USA |

¹²

Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, USA |

¹³

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA |

Publication type: Journal Article

Publication date: 2020-07-10

Springer Nature

Journal: Nature Medicine

Quartile SCImago

Quartile WOS

Impact factor: 82.9

ISSN: 10788956, 1546170X, 17447933

DOI: 10.1038/s41591-020-0998-x

Copy DOI

PubMed ID: 32651581

General Biochemistry, Genetics and Molecular Biology

General Medicine

Abstract

Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date1,2. In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. We stratify these mAbs into five major classes on the basis of their reactivity to subdomains of S protein as well as their cross-reactivity to SARS-CoV. Many of these mAbs inhibit infection of authentic SARS-CoV-2 virus, with most neutralizing mAbs recognizing the receptor-binding domain (RBD) of S. This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates the speed and robustness of advanced antibody discovery platforms. A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19.

By date By citations

Top-30

Citations by journals

	5 10 15 20 25
Cell Reports	Cell Reports, 22, 5.24% Cell Reports 22 publications, 5.24%
Frontiers in Immunology	Frontiers in Immunology, 14, 3.33% Frontiers in Immunology 14 publications, 3.33%
Cell	Cell, 11, 2.62% Cell 11 publications, 2.62%
Nature Communications	Nature Communications, 10, 2.38% Nature Communications 10 publications, 2.38%
Immunity	Immunity, 10, 2.38% Immunity 10 publications, 2.38%
Nature	Nature, 9, 2.14% Nature 9 publications, 2.14%
iScience	iScience, 8, 1.9% iScience 8 publications, 1.9%
Cell Host and Microbe	Cell Host and Microbe, 7, 1.67% Cell Host and Microbe 7 publications, 1.67%
Science	Science, 6, 1.43% Science 6 publications, 1.43%
Viruses	Viruses, 5, 1.19% Viruses 5 publications, 1.19%
mAbs	mAbs, 5, 1.19% mAbs 5 publications, 1.19%
Science Translational Medicine	Science Translational Medicine, 4, 0.95% Science Translational Medicine 4 publications, 0.95%
Vaccines	Vaccines, 4, 0.95% Vaccines 4 publications, 0.95%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 4, 0.95% Signal Transduction and Targeted Therapy 4 publications, 0.95%
Scientific Reports	Scientific Reports, 3, 0.71% Scientific Reports 3 publications, 0.71%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 0.71% International Journal of Molecular Sciences 3 publications, 0.71%
Frontiers in Microbiology	Frontiers in Microbiology, 3, 0.71% Frontiers in Microbiology 3 publications, 0.71%
Communications Biology	Communications Biology, 3, 0.71% Communications Biology 3 publications, 0.71%
Journal of Biomedical Science	Journal of Biomedical Science, 3, 0.71% Journal of Biomedical Science 3 publications, 0.71%
PLoS ONE	PLoS ONE, 3, 0.71% PLoS ONE 3 publications, 0.71%
Journal of Virology	Journal of Virology, 3, 0.71% Journal of Virology 3 publications, 0.71%
Journal of Clinical Investigation	Journal of Clinical Investigation, 2, 0.48% Journal of Clinical Investigation 2 publications, 0.48%
Biomedicines	Biomedicines, 2, 0.48% Biomedicines 2 publications, 0.48%
Pharmaceutics	Pharmaceutics, 2, 0.48% Pharmaceutics 2 publications, 0.48%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 2, 0.48% Frontiers in Cellular and Infection Microbiology 2 publications, 0.48%
Nature Medicine	Nature Medicine, 2, 0.48% Nature Medicine 2 publications, 0.48%
Cell Discovery	Cell Discovery, 2, 0.48% Cell Discovery 2 publications, 0.48%
Cellular and Molecular Immunology	Cellular and Molecular Immunology, 2, 0.48% Cellular and Molecular Immunology 2 publications, 0.48%
BioDrugs	BioDrugs, 2, 0.48% BioDrugs 2 publications, 0.48%
	5 10 15 20 25

Citations by publishers

	20 40 60 80 100 120
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 105, 25% Cold Spring Harbor Laboratory 105 publications, 25%
Elsevier	Elsevier, 100, 23.81% Elsevier 100 publications, 23.81%
Springer Nature	Springer Nature, 64, 15.24% Springer Nature 64 publications, 15.24%
Frontiers Media S.A.	Frontiers Media S.A., 23, 5.48% Frontiers Media S.A. 23 publications, 5.48%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 22, 5.24% Multidisciplinary Digital Publishing Institute (MDPI) 22 publications, 5.24%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 14, 3.33% American Association for the Advancement of Science (AAAS) 14 publications, 3.33%
Wiley	Wiley, 12, 2.86% Wiley 12 publications, 2.86%
Taylor & Francis	Taylor & Francis, 10, 2.38% Taylor & Francis 10 publications, 2.38%
Oxford University Press	Oxford University Press, 10, 2.38% Oxford University Press 10 publications, 2.38%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 9, 2.14% Public Library of Science (PLoS) 9 publications, 2.14%
American Society for Microbiology	American Society for Microbiology, 8, 1.9% American Society for Microbiology 8 publications, 1.9%
American Chemical Society (ACS)	American Chemical Society (ACS), 7, 1.67% American Chemical Society (ACS) 7 publications, 1.67%
Mary Ann Liebert	Mary Ann Liebert, 4, 0.95% Mary Ann Liebert 4 publications, 0.95%
American Society for Clinical Investigation	American Society for Clinical Investigation, 3, 0.71% American Society for Clinical Investigation 3 publications, 0.71%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 0.71% Royal Society of Chemistry (RSC) 3 publications, 0.71%
Annual Reviews	Annual Reviews, 3, 0.71% Annual Reviews 3 publications, 0.71%
Wolters Kluwer Health	Wolters Kluwer Health, 2, 0.48% Wolters Kluwer Health 2 publications, 0.48%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 2, 0.48% Proceedings of the National Academy of Sciences (PNAS) 2 publications, 0.48%
Rockefeller University Press	Rockefeller University Press, 2, 0.48% Rockefeller University Press 2 publications, 0.48%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.24% The American Association of Immunologists 1 publication, 0.24%
NEJM Group	NEJM Group, 1, 0.24% NEJM Group 1 publication, 0.24%
Social Science Electronic Publishing	Social Science Electronic Publishing, 1, 0.24% Social Science Electronic Publishing 1 publication, 0.24%
EMBO press	EMBO press, 1, 0.24% EMBO press 1 publication, 0.24%
IEEE	IEEE, 1, 0.24% IEEE 1 publication, 0.24%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.24% eLife Sciences Publications 1 publication, 0.24%
Pleiades Publishing	Pleiades Publishing, 1, 0.24% Pleiades Publishing 1 publication, 0.24%
Mediar Press	Mediar Press, 1, 0.24% Mediar Press 1 publication, 0.24%
AME Publishing Company	AME Publishing Company, 1, 0.24% AME Publishing Company 1 publication, 0.24%
Microbiology Society	Microbiology Society, 1, 0.24% Microbiology Society 1 publication, 0.24%
	20 40 60 80 100 120

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST |

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GOST Copy

Zost S. J. et al. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein // Nature Medicine. 2020. Vol. 26. No. 9. pp. 1422-1427.

GOST all authors (up to 50) Copy

Zost S. J., Gilchuk P., Chen R. E., Case J. B., Reidy J. X., Trivette A., Nargi R. S., Sutton R. E., Suryadevara N., Chen E. C., Binshtein E., Shrihari S., Ostrowski M., Chu H. Y., Didier J. E., MacRenaris K. W., Jones T., Day S., Myers L., Lee F. E., Nguyen D. C., Sanz I., Martinez D. R., Rothlauf P. W., Bloyet L. M., Whelan S., Baric R. S., Thackray L. B., Diamond M., Carnahan R. H., Crowe J. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein // Nature Medicine. 2020. Vol. 26. No. 9. pp. 1422-1427.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41591-020-0998-x

UR - https://doi.org/10.1038/s41591-020-0998-x

TI - Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

T2 - Nature Medicine

AU - Zost, Seth J.

AU - Gilchuk, Pavlo

AU - Chen, Rita E.

AU - Case, James Brett

AU - Reidy, Joseph X

AU - Trivette, Andrew

AU - Nargi, Rachel S.

AU - Sutton, Rachel E.

AU - Suryadevara, Naveenchandra

AU - Chen, Elaine C.

AU - Binshtein, Elad

AU - Shrihari, Swathi

AU - Ostrowski, Mario

AU - Chu, Helen Y.

AU - Didier, Jonathan E.

AU - MacRenaris, Keith W

AU - Jones, Taylor

AU - Day, Samuel

AU - Myers, Luke

AU - Lee, F. Eun-Hyung

AU - Nguyen, Doan C.

AU - Sanz, Ignacio

AU - Martinez, David R.

AU - Rothlauf, Paul W

AU - Bloyet, Louis Marie

AU - Whelan, Sean

AU - Baric, Ralph S

AU - Thackray, Larissa B

AU - Diamond, Michael S.

AU - Carnahan, Robert H.

AU - Crowe, James

PY - 2020

DA - 2020/07/10 00:00:00

PB - Springer Nature

SP - 1422-1427

IS - 9

VL - 26

PMID - 32651581

SN - 1078-8956

SN - 1546-170X

SN - 1744-7933

ER -

BibTex |

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BibTex Copy

@article{2020_Zost,

author = {Seth J. Zost and Pavlo Gilchuk and Rita E. Chen and James Brett Case and Joseph X Reidy and Andrew Trivette and Rachel S. Nargi and Rachel E. Sutton and Naveenchandra Suryadevara and Elaine C. Chen and Elad Binshtein and Swathi Shrihari and Mario Ostrowski and Helen Y. Chu and Jonathan E. Didier and Keith W MacRenaris and Taylor Jones and Samuel Day and Luke Myers and F. Eun-Hyung Lee and Doan C. Nguyen and Ignacio Sanz and David R. Martinez and Paul W Rothlauf and Louis Marie Bloyet and Sean Whelan and Ralph S Baric and Larissa B Thackray and Michael S. Diamond and Robert H. Carnahan and James Crowe},

title = {Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein},

journal = {Nature Medicine},

year = {2020},

volume = {26},

publisher = {Springer Nature},

month = {jul},

url = {https://doi.org/10.1038/s41591-020-0998-x},

number = {9},

pages = {1422--1427},

doi = {10.1038/s41591-020-0998-x}

}

MLA

Cite this

MLA Copy

Zost, Seth J., et al. “Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.” Nature Medicine, vol. 26, no. 9, Jul. 2020, pp. 1422-1427. https://doi.org/10.1038/s41591-020-0998-x.

Found error?

Publisher

Springer Nature

Journal

Nature Medicine

Quartile SCImago

Quartile WOS

Impact factor

82.9

ISSN

10788956 (Print)
1546170X (Electronic)
17447933 (Electronic)