Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[13,31,41,47,39,55,51,54,37,38],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["3.2","7.64","10.1","11.58","9.61","13.55","12.56","13.3","9.11","9.36"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Scientific Reports","ChemBioChem","Molecules","Nature Communications","Journal of the American Chemical Society","International Journal of Molecular Sciences","PLoS ONE","Nucleic Acids Research","Analytical Chemistry","The Analyst","Proceedings of the National Academy of Sciences of the United States of America","Nature Medicine","Advanced Drug Delivery Reviews","Journal of Proteome Research","Chemical Reviews","Molecular Biology","Nucleic Acid Therapeutics","Seminars in Immunopathology","Circulation","Biotechnology Advances","American Journal of Human Genetics","Methods","Journal of Allergy and Clinical Immunology","Biochimie","ACS Chemical Biology","RSC Chemical Biology","Science Translational Medicine","Journal of Clinical Microbiology","Methods in Molecular Biology"],"ids":[13767,12154,1770,3231,4813,14627,24963,23904,18157,9343,306,20436,12266,14208,13718,1134,8743,11724,25062,17421,15105,16671,13710,4794,2045,27133,358,6320,3516],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[9,8,7,7,7,6,6,6,5,5,5,4,4,4,4,4,3,3,3,3,3,3,3,3,3,3,3,3,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[2.22,1.97,1.72,1.72,1.72,1.48,1.48,1.48,1.23,1.23,1.23,0.99,0.99,0.99,0.99,0.99,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74,0.74],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","American Chemical Society (ACS)","Wiley","Cold Spring Harbor Laboratory","Multidisciplinary Digital Publishing Institute (MDPI)","Royal Society of Chemistry (RSC)","Wolters Kluwer Health","Oxford University Press","Frontiers Media S.A.","Public Library of Science (PLoS)","Pleiades Publishing","Taylor & Francis","Proceedings of the National Academy of Sciences (PNAS)","American Society for Clinical Investigation","Mary Ann Liebert","American Association for the Advancement of Science (AAAS)","American Society for Microbiology","American Thoracic Society","Association for Research in Vision and Ophthalmology (ARVO)","Radiation Research Society","American Society of Nephrology","Hindawi Limited","American Diabetes Association","American Medical Association (AMA)","The American Association of Immunologists","The Endocrine Society","European Respiratory Society (ERS)","Future Medicine"],"ids":[17,8,40,11,6909,202,123,32,19,208,344,101,18,162,564,230,189,142,3246,1778,2171,974,6921,253,2676,7871,2489,3289,6949],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/mxFdPe9qujsfvfYfcN0QOclAiYORFb0xrRlwV8gs_medium.webp","\/storage\/images\/resized\/aFa86lAy63Pq5tYKiOsH017UsgJA6uk6ed66C0Ns_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/y6coX2RdMAMXy0PTXCMVDlJvumyjAcjbT7WXoxjx_medium.webp","\/storage\/images\/resized\/5UMgKnFqPQsuIMt03SiGJWWld9jmDgeekKAEN0Wm_medium.webp","","\/storage\/images\/resized\/orS0jeKEmNluvTOmiw9eau2cDuw0NkXVV399uzuY_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/Vcp1mJE3h2yVzw4TTlfw73zQiRwX0TnSmBF8aJ1J_medium.webp","\/storage\/images\/resized\/brnEFyEeTGw9nlsHnEHbyCV6AqrisRCX7QF1dLtY_medium.webp","\/storage\/images\/resized\/Teo7jjEEA71rw8mjlFC8lDbYotZhhtZbL0J9gPs2_medium.webp","\/storage\/images\/resized\/ykVNlEVbd1r3y7sMfZorOnDlpU1cRYn1ESbDmhRe_medium.webp","\/storage\/images\/resized\/hMjtEcPnOlZu0Qdup5ZFVJML9APp6JeBF0xfZC5e_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp"],"datasets":[{"label":"","data":[64,59,38,31,30,27,24,11,10,10,7,7,7,5,4,4,4,3,2,2,2,2,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[15.76,14.53,9.36,7.64,7.39,6.65,5.91,2.71,2.46,2.46,1.72,1.72,1.72,1.23,0.99,0.99,0.99,0.74,0.49,0.49,0.49,0.49,0.49,0.49,0.49,0.25,0.25,0.25,0.25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,1,1,1,1,1,2,2,0,1],"percentage":["0","0.25","0.25","0.25","0.25","0.25","0.49","0.49","0","0.25"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,1,1,2,1,2,3,0,0],"percentage":["0","0","0.25","0.25","0.49","0.25","0.49","0.74","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[2,3,3,3,0,4,6,2,3,5],"percentage":["0.49","0.74","0.74","0.74","0","0.99","1.48","0.49","0.74","1.23"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[10,24,33,35,26,40,35,35,28,23],"percentage":["2.46","5.91","8.13","8.62","6.4","9.85","8.62","8.62","6.9","5.67"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,3,3,7,10,9,6,12,6,9],"percentage":["0.25","0.74","0.74","1.72","2.46","2.22","1.48","2.96","1.48","2.22"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,2,2,1,1,1,2,0,0],"percentage":["0","0","0.49","0.49","0.25","0.25","0.25","0.49","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,1,6,3,4,4,3,3,1,1],"percentage":["0.25","0.25","1.48","0.74","0.99","0.99","0.74","0.74","0.25","0.25"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[5,11,8,11,9,15,10,13,7,9],"percentage":["1.23","2.71","1.97","2.71","2.22","3.69","2.46","3.2","1.72","2.22"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[5,13,22,24,13,25,26,20,22,16],"percentage":["1.23","3.2","5.42","5.91","3.2","6.16","6.4","4.93","5.42","3.94"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[2,6,3,7,12,10,11,16,7,12],"percentage":["0.49","1.48","0.74","1.72","2.96","2.46","2.71","3.94","1.72","2.96"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}