Nature, volume 541, issue 7636, pages 228-232

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

MATSUMOTO Akinobu ¹

Pasut Alessandra ¹

Matsumoto Masaki ²

Yamashita Riu ³

Fung Jacqueline ¹

Monteleone Emanuele ^{1, 4}

Saghatelian Alan ⁵

Nakayama Keiichi I. ²

Clohessy John G ¹

Pandolfi Pier Paolo ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of Medicine and Pathology, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA |

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan |

Department of BioBank, Tohoku Medical Megabank Organization (ToMMo), Tohoku University, Sendai, Japan |

⁴

Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy |

⁵

The Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies, La Jolla, USA |

Publication type: Journal Article

Publication date: 2016-12-26

Springer Nature

Journal: Nature

Quartile SCImago

Quartile WOS

Impact factor: 64.8

ISSN: 00280836, 14764687

DOI: 10.1038/nature21034

Copy DOI

Multidisciplinary

Abstract

Although long non-coding RNAs (lncRNAs) are non-protein-coding transcripts by definition, recent studies have shown that a fraction of putative small open reading frames within lncRNAs are translated. However, the biological significance of these hidden polypeptides is still unclear. Here we identify and functionally characterize a novel polypeptide encoded by the lncRNA LINC00961. This polypeptide is conserved between human and mouse, is localized to the late endosome/lysosome and interacts with the lysosomal v-ATPase to negatively regulate mTORC1 activation. This regulation of mTORC1 is specific to activation of mTORC1 by amino acid stimulation, rather than by growth factors. Hence, we termed this polypeptide ‘small regulatory polypeptide of amino acid response’ (SPAR). We show that the SPAR-encoding lncRNA is highly expressed in a subset of tissues and use CRISPR/Cas9 engineering to develop a SPAR-polypeptide-specific knockout mouse while maintaining expression of the host lncRNA. We find that the SPAR-encoding lncRNA is downregulated in skeletal muscle upon acute injury, and using this in vivo model we establish that SPAR downregulation enables efficient activation of mTORC1 and promotes muscle regeneration. Our data provide a mechanism by which mTORC1 activation may be finely regulated in a tissue-specific manner in response to injury, and a paradigm by which lncRNAs encoding small polypeptides can modulate general biological pathways and processes to facilitate tissue-specific requirements, consistent with their restricted and highly regulated expression profile.

By date By citations

Citations by journals

	5 10 15 20 25
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 23, 5.16% International Journal of Molecular Sciences 23 publications, 5.16%
Frontiers in Genetics	Frontiers in Genetics, 12, 2.69% Frontiers in Genetics 12 publications, 2.69%
Frontiers in Physiology	Frontiers in Physiology, 8, 1.79% Frontiers in Physiology 8 publications, 1.79%
Nature Communications	Nature Communications, 8, 1.79% Nature Communications 8 publications, 1.79%
Frontiers in Oncology	Frontiers in Oncology, 7, 1.57% Frontiers in Oncology 7 publications, 1.57%
Briefings in Bioinformatics	Briefings in Bioinformatics, 7, 1.57% Briefings in Bioinformatics 7 publications, 1.57%
Nucleic Acids Research	Nucleic Acids Research, 6, 1.35% Nucleic Acids Research 6 publications, 1.35%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 6, 1.35% Frontiers in Cell and Developmental Biology 6 publications, 1.35%
Genes	Genes, 6, 1.35% Genes 6 publications, 1.35%
Non-coding RNA	Non-coding RNA, 6, 1.35% Non-coding RNA 6 publications, 1.35%
Cancer Letters	Cancer Letters, 6, 1.35% Cancer Letters 6 publications, 1.35%
Genome Research	Genome Research, 5, 1.12% Genome Research 5 publications, 1.12%
Cancers	Cancers, 4, 0.9% Cancers 4 publications, 0.9%
Cells	Cells, 4, 0.9% Cells 4 publications, 0.9%
Molecular Cancer	Molecular Cancer, 4, 0.9% Molecular Cancer 4 publications, 0.9%
Non-coding RNA Research	Non-coding RNA Research, 4, 0.9% Non-coding RNA Research 4 publications, 0.9%
Experimental Cell Research	Experimental Cell Research, 4, 0.9% Experimental Cell Research 4 publications, 0.9%
Cancer Research	Cancer Research, 4, 0.9% Cancer Research 4 publications, 0.9%
Gene	Gene, 4, 0.9% Gene 4 publications, 0.9%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 4, 0.9% Biomedicine and Pharmacotherapy 4 publications, 0.9%
Russian Journal of Bioorganic Chemistry	Russian Journal of Bioorganic Chemistry, 4, 0.9% Russian Journal of Bioorganic Chemistry 4 publications, 0.9%
Journal of Proteome Research	Journal of Proteome Research, 3, 0.67% Journal of Proteome Research 3 publications, 0.67%
Cancer Cell International	Cancer Cell International, 3, 0.67% Cancer Cell International 3 publications, 0.67%
Aging	Aging, 3, 0.67% Aging 3 publications, 0.67%
Molecular Medicine Reports	Molecular Medicine Reports, 3, 0.67% Molecular Medicine Reports 3 publications, 0.67%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 3, 0.67% Frontiers in Molecular Biosciences 3 publications, 0.67%
BMC Genomics	BMC Genomics, 3, 0.67% BMC Genomics 3 publications, 0.67%
Science China Life Sciences	Science China Life Sciences, 3, 0.67% Science China Life Sciences 3 publications, 0.67%
Molecular Therapy	Molecular Therapy, 3, 0.67% Molecular Therapy 3 publications, 0.67%
	5 10 15 20 25

Citations by publishers

	10 20 30 40 50 60 70 80 90
Elsevier	Elsevier, 90, 20.18% Elsevier 90 publications, 20.18%
Springer Nature	Springer Nature, 53, 11.88% Springer Nature 53 publications, 11.88%
Frontiers Media S.A.	Frontiers Media S.A., 48, 10.76% Frontiers Media S.A. 48 publications, 10.76%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 47, 10.54% Multidisciplinary Digital Publishing Institute (MDPI) 47 publications, 10.54%
Wiley	Wiley, 32, 7.17% Wiley 32 publications, 7.17%
Oxford University Press	Oxford University Press, 30, 6.73% Oxford University Press 30 publications, 6.73%
Pleiades Publishing	Pleiades Publishing, 10, 2.24% Pleiades Publishing 10 publications, 2.24%
Taylor & Francis	Taylor & Francis, 10, 2.24% Taylor & Francis 10 publications, 2.24%
Spandidos Publications	Spandidos Publications, 9, 2.02% Spandidos Publications 9 publications, 2.02%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 1.35% American Chemical Society (ACS) 6 publications, 1.35%
Impact Journals	Impact Journals, 5, 1.12% Impact Journals 5 publications, 1.12%
KeAi Communications Co.	KeAi Communications Co., 5, 1.12% KeAi Communications Co. 5 publications, 1.12%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 5, 1.12% American Association for Cancer Research (AACR) 5 publications, 1.12%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 5, 1.12% Cold Spring Harbor Laboratory 5 publications, 1.12%
Bentham Science	Bentham Science, 4, 0.9% Bentham Science 4 publications, 0.9%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 4, 0.9% American Association for the Advancement of Science (AAAS) 4 publications, 0.9%
EMBO press	EMBO press, 4, 0.9% EMBO press 4 publications, 0.9%
Mary Ann Liebert	Mary Ann Liebert, 3, 0.67% Mary Ann Liebert 3 publications, 0.67%
American Society for Microbiology	American Society for Microbiology, 3, 0.67% American Society for Microbiology 3 publications, 0.67%
Hindawi Limited	Hindawi Limited, 3, 0.67% Hindawi Limited 3 publications, 0.67%
PeerJ	PeerJ, 2, 0.45% PeerJ 2 publications, 0.45%
American Society for Clinical Investigation	American Society for Clinical Investigation, 2, 0.45% American Society for Clinical Investigation 2 publications, 0.45%
Portland Press	Portland Press, 2, 0.45% Portland Press 2 publications, 0.45%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 0.45% Public Library of Science (PLoS) 2 publications, 0.45%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 0.45% Royal Society of Chemistry (RSC) 2 publications, 0.45%
American Physiological Society	American Physiological Society, 2, 0.45% American Physiological Society 2 publications, 0.45%
Rockefeller University Press	Rockefeller University Press, 2, 0.45% Rockefeller University Press 2 publications, 0.45%
Annual Reviews	Annual Reviews, 2, 0.45% Annual Reviews 2 publications, 0.45%
AME Publishing Company	AME Publishing Company, 2, 0.45% AME Publishing Company 2 publications, 0.45%
	10 20 30 40 50 60 70 80 90

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","",""],"datasets":[{"label":"Citations number","data":[34,55,57,68,100,66,59,7],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["7.62","12.33","12.78","15.25","22.42","14.8","13.23","1.57"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Frontiers in Genetics","Frontiers in Physiology","Nature Communications","Frontiers in Oncology","Briefings in Bioinformatics","Nucleic Acids Research","Frontiers in Cell and Developmental Biology","Genes","Non-coding RNA","Cancer Letters","Genome Research","Cancers","Cells","Molecular Cancer","Non-coding RNA Research","Experimental Cell Research","Cancer Research","Gene","Biomedicine and Pharmacotherapy","Russian Journal of Bioorganic Chemistry","Journal of Proteome Research","Cancer Cell International","Aging","Molecular Medicine Reports","Frontiers in Molecular Biosciences","BMC Genomics","Science China Life Sciences","Molecular Therapy"],"ids":[14627,13242,15670,3231,10990,23409,23904,12128,8879,18908,1654,9342,22471,25293,21240,7055,525,11199,2111,23951,13594,14208,9737,780,4737,3133,7708,8991,2784],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/cfuVw6XIq2mATDNJdXiose3W8qYbkmaVSpHoP8XL_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[23,12,8,8,7,7,6,6,6,6,6,5,4,4,4,4,4,4,4,4,4,3,3,3,3,3,3,3,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.16,2.69,1.79,1.79,1.57,1.57,1.35,1.35,1.35,1.35,1.35,1.12,0.9,0.9,0.9,0.9,0.9,0.9,0.9,0.9,0.9,0.67,0.67,0.67,0.67,0.67,0.67,0.67,0.67],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Frontiers Media S.A.","Multidisciplinary Digital Publishing Institute (MDPI)","Wiley","Oxford University Press","Pleiades Publishing","Taylor & Francis","Spandidos Publications","American Chemical Society (ACS)","Impact Journals","KeAi Communications Co.","American Association for Cancer Research (AACR)","Cold Spring Harbor Laboratory","Bentham Science","American Association for the Advancement of Science (AAAS)","EMBO press","Mary Ann Liebert","American Society for Microbiology","Hindawi Limited","PeerJ","American Society for Clinical Investigation","Portland Press","Public Library of Science (PLoS)","Royal Society of Chemistry (RSC)","American Physiological Society","Rockefeller University Press","Annual Reviews","AME Publishing Company"],"ids":[17,8,208,202,11,19,101,18,1097,40,342,326,2286,6909,39,189,9415,230,142,6921,1089,564,801,344,123,166,22,6941,1566],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/8zKfOwdd5XirYzTQfqwp7U8IEQc8ckIOjyYQSBkk_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/HY0CXgRt044tzIAB16PDvDzdHeKHGtSvlMH0yWf6_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/cfuVw6XIq2mATDNJdXiose3W8qYbkmaVSpHoP8XL_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/s10mcsCV4OAUg9O2KrqOquQC0PhyLMI8hUUkuflM_medium.webp","\/storage\/images\/resized\/1UiI5HycPsvulDeXOySNp0OuaMMmIKfPnsdKPyH0_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/aOPqEqNWK2Sq9T8CLDlsR6diWsFkHppx3bLsAnpx_medium.webp","\/storage\/images\/resized\/aFa86lAy63Pq5tYKiOsH017UsgJA6uk6ed66C0Ns_medium.webp","\/storage\/images\/resized\/nUqNrP9GnM1t0BrAIXp1LBodjU8aIJ2Fk4pLfGhZ_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/eZQGZ1aBN8Xm8Yr5YG7nBeNQtWLPrca5SfDreLbq_medium.webp","\/storage\/images\/resized\/lEA1FyUnFAZR1DchuczZi5bjAixG3TNeWVz6oF4R_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/PYBAYQjpFdxPQPRGY3kU5Xzbu0W7K7umVNk0TY9i_medium.webp"],"datasets":[{"label":"","data":[90,53,48,47,32,30,10,10,9,6,5,5,5,5,4,4,4,3,3,3,2,2,2,2,2,2,2,2,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20.18,11.88,10.76,10.54,7.17,6.73,2.24,2.24,2.02,1.35,1.12,1.12,1.12,1.12,0.9,0.9,0.9,0.67,0.67,0.67,0.45,0.45,0.45,0.45,0.45,0.45,0.45,0.45,0.45],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

MATSUMOTO A. et al. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide // Nature. 2016. Vol. 541. No. 7636. pp. 228-232.

GOST all authors (up to 50) Copy

MATSUMOTO A., Pasut A., Matsumoto M., Yamashita R., Fung J., Monteleone E., Saghatelian A., Nakayama K. I., Clohessy J. G., Pandolfi P. P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide // Nature. 2016. Vol. 541. No. 7636. pp. 228-232.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/nature21034

UR - https://doi.org/10.1038%2Fnature21034

TI - mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

T2 - Nature

AU - MATSUMOTO, Akinobu

AU - Pasut, Alessandra

AU - Matsumoto, Masaki

AU - Yamashita, Riu

AU - Fung, Jacqueline

AU - Monteleone, Emanuele

AU - Saghatelian, Alan

AU - Nakayama, Keiichi I.

AU - Clohessy, John G

AU - Pandolfi, Pier Paolo

PY - 2016

DA - 2016/12/26 00:00:00

PB - Springer Nature

SP - 228-232

IS - 7636

VL - 541

SN - 0028-0836

SN - 1476-4687

ER -

BibTex |

Cite this

BibTex Copy

@article{2016_MATSUMOTO,

author = {Akinobu MATSUMOTO and Alessandra Pasut and Masaki Matsumoto and Riu Yamashita and Jacqueline Fung and Emanuele Monteleone and Alan Saghatelian and Keiichi I. Nakayama and John G Clohessy and Pier Paolo Pandolfi},

title = {mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide},

journal = {Nature},

year = {2016},

volume = {541},

publisher = {Springer Nature},

month = {dec},

url = {https://doi.org/10.1038%2Fnature21034},

number = {7636},

pages = {228--232},

doi = {10.1038/nature21034}

}

MLA

Cite this

MLA Copy

MATSUMOTO, Akinobu, et al. “mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.” Nature, vol. 541, no. 7636, Dec. 2016, pp. 228-232. https://doi.org/10.1038%2Fnature21034.

Found error?

Publisher

Springer Nature

Journal

Nature

Quartile SCImago

Quartile WOS

Impact factor

64.8

ISSN

00280836 (Print)
14764687 (Electronic)