Open Access

Nature Communications, volume 6, issue 1, publication number 6158

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Schosserer Markus ¹

Minois Nadège ²

Angerer Tina B ³

Amring Manuela ³

Dellago Hanna ^{1, 4}

Harreither Eva ¹

Calle Perez Alfonso ¹

Pircher Andreas ⁵

Gerstl Matthias Peter ⁶

Pfeifenberger Sigrid ³

Brandl Clemens ³

Sonntagbauer Markus ⁷

Kriegner Albert ⁷

Linder Angela ⁸

Weinhäusel Andreas ⁷

Mohr Thomas ⁹

Steiger Matthias ^{1, 6}

Mattanovich Diethard ^{1, 6}

Rinnerthaler Mark ³

THOMAS KARL ³

Sharma Sunny ¹⁰

Entian Karl-Dieter ¹⁰

Kos Martin ¹¹

Breitenbach Michael ³

WILSON Iain B. H. ⁸

Polacek Norbert ⁵

Grillari-Voglauer Regina ^{1, 6, 12}

Breitenbach-Koller Lore ³

Grillari Johannes ^{1, 4, 6, 12}

Hide authors affiliations Show authors affiliations: 12 affiliations

Department of Biotechnology, BOKU—University of Natural Resources and Life Sciences, Vienna, Vienna, Austria |

Biomedical Sciences Research Complex, University of St Andrews, Fife, UK |

Department of Cell Biology, Division of Genetics, University of Salzburg, Salzburg, Austria |

⁴

Christian Doppler Laboratory on Biotechnology of Skin Aging, Vienna, Austria |

⁵

Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland |

⁶

ACIB GmbH–Austrian Centre of Industrial Biotechnology, Vienna, Austria |

⁷

Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Vienna, Austria |

⁸

Department of Chemistry, BOKU—University of Natural Resources and Life Sciences, Vienna, Vienna, Austria |

⁹

Science Consult DI Thomas Mohr KG, Guntramsdorf, Austria |

¹⁰

Department of Molecular Genetics & Cellular Microbiology, Institute of Molecular Biosciences, Goethe University, Frankfurt/M, Germany |

¹¹

Biochemie-Zentrum Der Universität Heidelberg (Bzh), Heidelberg, Germany |

¹²

Evercyte GmbH, Vienna, Austria |

Publication type: Journal Article

Publication date: 2015-01-30

Springer Nature

Journal: Nature Communications

Quartile SCImago

Quartile WOS

Impact factor: 16.6

ISSN: 20411723

DOI: 10.1038/ncomms7158

Copy DOI

PubMed ID: 25635753

General Chemistry

General Biochemistry, Genetics and Molecular Biology

General Physics and Astronomy

Abstract

Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in yeast, worms and flies. Rcm1, the yeast homologue of NSUN5, methylates C2278 within a conserved region of 25S rRNA. Loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes. Thus, rather than merely being a static molecular machine executing translation, the ribosome exhibits functional diversity by modification of just a single rRNA nucleotide, resulting in an alteration of organismal physiological behaviour, and linking rRNA-mediated translational regulation to modulation of lifespan, and differential stress response.

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	2 4 6 8 10 12 14
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Cell Reports	Cell Reports, 3, 1.4% Cell Reports 3 publications, 1.4%
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Nature Chemical Biology	Nature Chemical Biology, 2, 0.93% Nature Chemical Biology 2 publications, 0.93%
Ageing Research Reviews	Ageing Research Reviews, 2, 0.93% Ageing Research Reviews 2 publications, 0.93%
Journal of Cell Science	Journal of Cell Science, 2, 0.93% Journal of Cell Science 2 publications, 0.93%
Biochemical Society Transactions	Biochemical Society Transactions, 2, 0.93% Biochemical Society Transactions 2 publications, 0.93%
Genes	Genes, 2, 0.93% Genes 2 publications, 0.93%
Cells	Cells, 2, 0.93% Cells 2 publications, 0.93%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 2, 0.93% Frontiers in Molecular Biosciences 2 publications, 0.93%
BMC Genomics	BMC Genomics, 2, 0.93% BMC Genomics 2 publications, 0.93%
PLoS ONE	PLoS ONE, 2, 0.93% PLoS ONE 2 publications, 0.93%
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RNA	RNA, 2, 0.93% RNA 2 publications, 0.93%
KAGAKU TO SEIBUTSU	KAGAKU TO SEIBUTSU, 2, 0.93% KAGAKU TO SEIBUTSU 2 publications, 0.93%
	2 4 6 8 10 12 14

Citations by publishers

	5 10 15 20 25 30 35 40 45
Springer Nature	Springer Nature, 45, 21.03% Springer Nature 45 publications, 21.03%
Elsevier	Elsevier, 31, 14.49% Elsevier 31 publications, 14.49%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 26, 12.15% Multidisciplinary Digital Publishing Institute (MDPI) 26 publications, 12.15%
Wiley	Wiley, 18, 8.41% Wiley 18 publications, 8.41%
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Impact Journals	Impact Journals, 3, 1.4% Impact Journals 3 publications, 1.4%
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Portland Press	Portland Press, 2, 0.93% Portland Press 2 publications, 0.93%
Spandidos Publications	Spandidos Publications, 2, 0.93% Spandidos Publications 2 publications, 0.93%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 0.93% Public Library of Science (PLoS) 2 publications, 0.93%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 2, 0.93% American Association for Cancer Research (AACR) 2 publications, 0.93%
Japan Society for Bioscience, Biotechnology, and Agrochemistry	Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2, 0.93% Japan Society for Bioscience, Biotechnology, and Agrochemistry 2 publications, 0.93%
Pleiades Publishing	Pleiades Publishing, 1, 0.47% Pleiades Publishing 1 publication, 0.47%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.47% The American Association of Immunologists 1 publication, 0.47%
IOS Press	IOS Press, 1, 0.47% IOS Press 1 publication, 0.47%
The Royal Society	The Royal Society, 1, 0.47% The Royal Society 1 publication, 0.47%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 0.47% Wolters Kluwer Health 1 publication, 0.47%
Canadian Science Publishing	Canadian Science Publishing, 1, 0.47% Canadian Science Publishing 1 publication, 0.47%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 0.47% Royal Society of Chemistry (RSC) 1 publication, 0.47%
Walter de Gruyter	Walter de Gruyter, 1, 0.47% Walter de Gruyter 1 publication, 0.47%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.47% American Association for the Advancement of Science (AAAS) 1 publication, 0.47%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 0.47% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 0.47%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.47% eLife Sciences Publications 1 publication, 0.47%
Annual Reviews	Annual Reviews, 1, 0.47% Annual Reviews 1 publication, 0.47%
	5 10 15 20 25 30 35 40 45

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Schosserer M. et al. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan // Nature Communications. 2015. Vol. 6. No. 1. 6158

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Schosserer M., Minois N., Angerer T. B., Amring M., Dellago H., Harreither E., Calle Perez A., Pircher A., Gerstl M. P., Pfeifenberger S., Brandl C., Sonntagbauer M., Kriegner A., Linder A., Weinhäusel A., Mohr T., Steiger M., Mattanovich D., Rinnerthaler M., THOMAS K., Sharma S., Entian K., Kos M., Breitenbach M., WILSON I., Polacek N., Grillari-Voglauer R., Breitenbach-Koller L., Grillari J. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan // Nature Communications. 2015. Vol. 6. No. 1. 6158

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TY - JOUR

DO - 10.1038/ncomms7158

UR - https://doi.org/10.1038%2Fncomms7158

TI - Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

T2 - Nature Communications

AU - Schosserer, Markus

AU - Minois, Nadège

AU - Angerer, Tina B

AU - Amring, Manuela

AU - Dellago, Hanna

AU - Harreither, Eva

AU - Calle Perez, Alfonso

AU - Pircher, Andreas

AU - Gerstl, Matthias Peter

AU - Pfeifenberger, Sigrid

AU - Brandl, Clemens

AU - Sonntagbauer, Markus

AU - Kriegner, Albert

AU - Linder, Angela

AU - Weinhäusel, Andreas

AU - Mohr, Thomas

AU - Steiger, Matthias

AU - Mattanovich, Diethard

AU - Rinnerthaler, Mark

AU - THOMAS, KARL

AU - Sharma, Sunny

AU - Entian, Karl-Dieter

AU - Kos, Martin

AU - Breitenbach, Michael

AU - WILSON, Iain B. H.

AU - Polacek, Norbert

AU - Grillari-Voglauer, Regina

AU - Breitenbach-Koller, Lore

AU - Grillari, Johannes

PY - 2015

DA - 2015/01/30 00:00:00

PB - Springer Nature

IS - 1

VL - 6

PMID - 25635753

SN - 2041-1723

ER -

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BibTex Copy

@article{2015_Schosserer,

author = {Markus Schosserer and Nadège Minois and Tina B Angerer and Manuela Amring and Hanna Dellago and Eva Harreither and Alfonso Calle Perez and Andreas Pircher and Matthias Peter Gerstl and Sigrid Pfeifenberger and Clemens Brandl and Markus Sonntagbauer and Albert Kriegner and Angela Linder and Andreas Weinhäusel and Thomas Mohr and Matthias Steiger and Diethard Mattanovich and Mark Rinnerthaler and KARL THOMAS and Sunny Sharma and Karl-Dieter Entian and Martin Kos and Michael Breitenbach and Iain B. H. WILSON and Norbert Polacek and Regina Grillari-Voglauer and Lore Breitenbach-Koller and Johannes Grillari},

title = {Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan},

journal = {Nature Communications},

year = {2015},

volume = {6},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038%2Fncomms7158},

number = {1},

doi = {10.1038/ncomms7158}

}

Found error?

Publisher

Springer Nature

Journal

Nature Communications

Quartile SCImago

Quartile WOS

Impact factor

16.6

ISSN

20411723 (Print)