Nature Materials, volume 8, issue 7, pages 543-557

Understanding biophysicochemical interactions at the nano–bio interface

Andre E. Nel ¹

Lutz Mädler ²

Darrell Velegol ³

Tian Xia ¹

Eric M V Hoek ⁴

Ponisseril Somasundaran ⁵

Fred Klaessig ⁶

Vince Castranova ⁷

Mike Thompson ⁸

Hide authors affiliations Show authors affiliations: 8 affiliations

Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, USA |

Department of Production Engineering, Foundation Institute of Materials Science (IWT), University of Bremen, Germany |

Department of Chemical Engineering, Penn State University, University Park, USA |

⁴

Civil & Environmental Engineering Department, and California NanoSystems Institute at UCLA, Los Angeles, USA |

⁵

Department of Earth and Environmental Engineering, Langmuir Center for Colloids and Interfaces, Columbia University, New York, USA |

⁶

Pennsylvania Bio Nano Systems, 3805 Old Easton Road, Doylestown, USA |

⁷

NIOSH, Morgantown, USA |

⁸

FEI Company, Hillsboro, USA |

Publication type: Journal Article

Publication date: 2009-06-14

Springer Nature

Journal: Nature Materials

Quartile SCImago

Quartile WOS

Impact factor: 41.2

ISSN: 14761122, 14764660

DOI: 10.1038/nmat2442

Copy DOI

General Chemistry

Condensed Matter Physics

General Materials Science

Mechanical Engineering

Mechanics of Materials

Abstract

Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.

By date By citations

Top-30

Citations by journals

	20 40 60 80 100 120 140 160 180 200
ACS Nano	ACS Nano, 196, 3.41% ACS Nano 196 publications, 3.41%
Nanoscale	Nanoscale, 183, 3.18% Nanoscale 183 publications, 3.18%
Langmuir	Langmuir, 137, 2.38% Langmuir 137 publications, 2.38%
ACS applied materials & interfaces	ACS applied materials & interfaces, 117, 2.03% ACS applied materials & interfaces 117 publications, 2.03%
Small	Small, 104, 1.81% Small 104 publications, 1.81%
Biomaterials	Biomaterials, 85, 1.48% Biomaterials 85 publications, 1.48%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 82, 1.42% Colloids and Surfaces B: Biointerfaces 82 publications, 1.42%
Nanomaterials	Nanomaterials, 73, 1.27% Nanomaterials 73 publications, 1.27%
RSC Advances	RSC Advances, 68, 1.18% RSC Advances 68 publications, 1.18%
Scientific Reports	Scientific Reports, 64, 1.11% Scientific Reports 64 publications, 1.11%
Journal of Controlled Release	Journal of Controlled Release, 64, 1.11% Journal of Controlled Release 64 publications, 1.11%
Nanotoxicology	Nanotoxicology, 62, 1.08% Nanotoxicology 62 publications, 1.08%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 61, 1.06% Journal of Materials Chemistry B 61 publications, 1.06%
Nanomedicine	Nanomedicine, 60, 1.04% Nanomedicine 60 publications, 1.04%
Advanced Materials	Advanced Materials, 53, 0.92% Advanced Materials 53 publications, 0.92%
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 52, 0.9% Journal of Physical Chemistry C 52 publications, 0.9%
Soft Matter	Soft Matter, 48, 0.83% Soft Matter 48 publications, 0.83%
Environmental Science & Technology	Environmental Science & Technology, 47, 0.82% Environmental Science & Technology 47 publications, 0.82%
Environmental Science: Nano	Environmental Science: Nano, 47, 0.82% Environmental Science: Nano 47 publications, 0.82%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 43, 0.75% International Journal of Molecular Sciences 43 publications, 0.75%
Journal of Nanoparticle Research	Journal of Nanoparticle Research, 43, 0.75% Journal of Nanoparticle Research 43 publications, 0.75%
Nano Letters	Nano Letters, 40, 0.69% Nano Letters 40 publications, 0.69%
Journal of the American Chemical Society	Journal of the American Chemical Society, 39, 0.68% Journal of the American Chemical Society 39 publications, 0.68%
Nature Communications	Nature Communications, 38, 0.66% Nature Communications 38 publications, 0.66%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 38, 0.66% Advanced Drug Delivery Reviews 38 publications, 0.66%
Advanced Functional Materials	Advanced Functional Materials, 38, 0.66% Advanced Functional Materials 38 publications, 0.66%
Journal of Colloid and Interface Science	Journal of Colloid and Interface Science, 37, 0.64% Journal of Colloid and Interface Science 37 publications, 0.64%
Angewandte Chemie	Angewandte Chemie, 37, 0.64% Angewandte Chemie 37 publications, 0.64%
Chemical Society Reviews	Chemical Society Reviews, 37, 0.64% Chemical Society Reviews 37 publications, 0.64%
	20 40 60 80 100 120 140 160 180 200

Citations by publishers

	200 400 600 800 1000 1200 1400 1600
Elsevier	Elsevier, 1475, 25.63% Elsevier 1475 publications, 25.63%
American Chemical Society (ACS)	American Chemical Society (ACS), 974, 16.92% American Chemical Society (ACS) 974 publications, 16.92%
Wiley	Wiley, 658, 11.43% Wiley 658 publications, 11.43%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 640, 11.12% Royal Society of Chemistry (RSC) 640 publications, 11.12%
Springer Nature	Springer Nature, 633, 11% Springer Nature 633 publications, 11%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 280, 4.86% Multidisciplinary Digital Publishing Institute (MDPI) 280 publications, 4.86%
Taylor & Francis	Taylor & Francis, 178, 3.09% Taylor & Francis 178 publications, 3.09%
Future Medicine	Future Medicine, 69, 1.2% Future Medicine 69 publications, 1.2%
Frontiers Media S.A.	Frontiers Media S.A., 63, 1.09% Frontiers Media S.A. 63 publications, 1.09%
IOP Publishing	IOP Publishing, 59, 1.03% IOP Publishing 59 publications, 1.03%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 33, 0.57% Public Library of Science (PLoS) 33 publications, 0.57%
Hindawi Limited	Hindawi Limited, 30, 0.52% Hindawi Limited 30 publications, 0.52%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 26, 0.45% American Institute of Physics (AIP) 26 publications, 0.45%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 22, 0.38% Cold Spring Harbor Laboratory 22 publications, 0.38%
Pleiades Publishing	Pleiades Publishing, 21, 0.36% Pleiades Publishing 21 publications, 0.36%
Oxford University Press	Oxford University Press, 20, 0.35% Oxford University Press 20 publications, 0.35%
Beilstein-Institut	Beilstein-Institut, 16, 0.28% Beilstein-Institut 16 publications, 0.28%
SAGE	SAGE, 16, 0.28% SAGE 16 publications, 0.28%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 16, 0.28% Proceedings of the National Academy of Sciences (PNAS) 16 publications, 0.28%
Walter de Gruyter	Walter de Gruyter, 14, 0.24% Walter de Gruyter 14 publications, 0.24%
Dove Medical Press	Dove Medical Press, 13, 0.23% Dove Medical Press 13 publications, 0.23%
American Physical Society (APS)	American Physical Society (APS), 12, 0.21% American Physical Society (APS) 12 publications, 0.21%
The Royal Society	The Royal Society, 12, 0.21% The Royal Society 12 publications, 0.21%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 11, 0.19% American Association for the Advancement of Science (AAAS) 11 publications, 0.19%
Bentham Science	Bentham Science, 10, 0.17% Bentham Science 10 publications, 0.17%
World Scientific	World Scientific, 10, 0.17% World Scientific 10 publications, 0.17%
IEEE	IEEE, 9, 0.16% IEEE 9 publications, 0.16%
American Vacuum Society	American Vacuum Society, 8, 0.14% American Vacuum Society 8 publications, 0.14%
Mary Ann Liebert	Mary Ann Liebert, 8, 0.14% Mary Ann Liebert 8 publications, 0.14%
	200 400 600 800 1000 1200 1400 1600

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Nel A. E. et al. Understanding biophysicochemical interactions at the nano–bio interface // Nature Materials. 2009. Vol. 8. No. 7. pp. 543-557.

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Nel A. E., Mädler L., Velegol D., Xia T., Hoek E. M. V., Somasundaran P., Klaessig F., Castranova V., Thompson M. Understanding biophysicochemical interactions at the nano–bio interface // Nature Materials. 2009. Vol. 8. No. 7. pp. 543-557.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nmat2442

UR - https://doi.org/10.1038/nmat2442

TI - Understanding biophysicochemical interactions at the nano–bio interface

T2 - Nature Materials

AU - Nel, Andre E.

AU - Mädler, Lutz

AU - Velegol, Darrell

AU - Xia, Tian

AU - Hoek, Eric M V

AU - Somasundaran, Ponisseril

AU - Klaessig, Fred

AU - Castranova, Vince

AU - Thompson, Mike

PY - 2009

DA - 2009/06/14 00:00:00

PB - Springer Nature

SP - 543-557

IS - 7

VL - 8

SN - 1476-1122

SN - 1476-4660

ER -

BibTex |

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BibTex Copy

@article{2009_Nel,

author = {Andre E. Nel and Lutz Mädler and Darrell Velegol and Tian Xia and Eric M V Hoek and Ponisseril Somasundaran and Fred Klaessig and Vince Castranova and Mike Thompson},

title = {Understanding biophysicochemical interactions at the nano–bio interface},

journal = {Nature Materials},

year = {2009},

volume = {8},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1038/nmat2442},

number = {7},

pages = {543--557},

doi = {10.1038/nmat2442}

}

MLA

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MLA Copy

Nel, Andre E., et al. “Understanding biophysicochemical interactions at the nano–bio interface.” Nature Materials, vol. 8, no. 7, Jun. 2009, pp. 543-557. https://doi.org/10.1038/nmat2442.

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Publisher

Springer Nature

Journal

Nature Materials

Quartile SCImago

Quartile WOS

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41.2

ISSN

14761122 (Print)
14764660 (Electronic)