Nature Nanotechnology, volume 5, issue 3, pages 200-203

Single-molecule chemical reactions on DNA origami

Voigt Niels V 1, 2
Tørring Thomas 1, 2
Rotaru Alexandru 1, 2
Jacobsen Mikkel F 1, 2
Ravnsbæk Jens B. 1, 2
Subramani Ramesh 2, 3
Mamdouh Wael 2, 3
Kjems Jørgen 2, 4
Mokhir Andriy 5
Besenbacher Flemming 2, 3
Gothelf Kurt Vesterager 1, 2
Publication typeJournal Article
Publication date2010-02-28
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor38.3
ISSN17483387, 17483395
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
General Materials Science
Electrical and Electronic Engineering
Bioengineering
Biomedical Engineering
Abstract
DNA nanotechnology and particularly DNA origami, in which long, single-stranded DNA molecules are folded into predetermined shapes, can be used to form complex self-assembled nanostructures. Although DNA itself has limited chemical, optical or electronic functionality, DNA nanostructures can serve as templates for building materials with new functional properties. Relatively large nanocomponents such as nanoparticles and biomolecules can also be integrated into DNA nanostructures and imaged. Here, we show that chemical reactions with single molecules can be performed and imaged at a local position on a DNA origami scaffold by atomic force microscopy. The high yields and chemoselectivities of successive cleavage and bond-forming reactions observed in these experiments demonstrate the feasibility of post-assembly chemical modification of DNA nanostructures and their potential use as locally addressable solid supports.

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GOST Copy
Voigt N. V. et al. Single-molecule chemical reactions on DNA origami // Nature Nanotechnology. 2010. Vol. 5. No. 3. pp. 200-203.
GOST all authors (up to 50) Copy
Voigt N. V., Tørring T., Rotaru A., Jacobsen M. F., Ravnsbæk J. B., Subramani R., Mamdouh W., Kjems J., Mokhir A., Besenbacher F., Gothelf K. V. Single-molecule chemical reactions on DNA origami // Nature Nanotechnology. 2010. Vol. 5. No. 3. pp. 200-203.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/nnano.2010.5
UR - https://doi.org/10.1038%2Fnnano.2010.5
TI - Single-molecule chemical reactions on DNA origami
T2 - Nature Nanotechnology
AU - Voigt, Niels V
AU - Tørring, Thomas
AU - Rotaru, Alexandru
AU - Jacobsen, Mikkel F
AU - Ravnsbæk, Jens B.
AU - Subramani, Ramesh
AU - Mamdouh, Wael
AU - Kjems, Jørgen
AU - Mokhir, Andriy
AU - Besenbacher, Flemming
AU - Gothelf, Kurt Vesterager
PY - 2010
DA - 2010/02/28 00:00:00
PB - Springer Nature
SP - 200-203
IS - 3
VL - 5
SN - 1748-3387
SN - 1748-3395
ER -
BibTex |
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BibTex Copy
@article{2010_Voigt,
author = {Niels V Voigt and Thomas Tørring and Alexandru Rotaru and Mikkel F Jacobsen and Jens B. Ravnsbæk and Ramesh Subramani and Wael Mamdouh and Jørgen Kjems and Andriy Mokhir and Flemming Besenbacher and Kurt Vesterager Gothelf},
title = {Single-molecule chemical reactions on DNA origami},
journal = {Nature Nanotechnology},
year = {2010},
volume = {5},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038%2Fnnano.2010.5},
number = {3},
pages = {200--203},
doi = {10.1038/nnano.2010.5}
}
MLA
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MLA Copy
Voigt, Niels V., et al. “Single-molecule chemical reactions on DNA origami.” Nature Nanotechnology, vol. 5, no. 3, Feb. 2010, pp. 200-203. https://doi.org/10.1038%2Fnnano.2010.5.
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