The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Publication type: Journal Article
Publication date: 2007-02-01
scimago Q1
wos Q1
SJR: 5.854
CiteScore: 27.6
Impact factor: 16.0
ISSN: 17542189, 17502799
PubMed ID:
17406592
General Biochemistry, Genetics and Molecular Biology
Abstract
The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior. Briefly, rats or mice are placed at the junction of the four arms of the maze, facing an open arm, and entries/duration in each arm are recorded by a video-tracking system and observer simultaneously for 5 min. Other ethological parameters (i.e., rears, head dips and stretched-attend postures) can also be observed. An increase in open arm activity (duration and/or entries) reflects anti-anxiety behavior. In our laboratory, rats or mice are exposed to the plus maze on one occasion; thus, results can be obtained in 5 min per rodent.
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Walf A. A. et al. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents // Nature Protocols. 2007. Vol. 2. No. 2. pp. 322-328.
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Walf A. A., Frye C. A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents // Nature Protocols. 2007. Vol. 2. No. 2. pp. 322-328.
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TY - JOUR
DO - 10.1038/nprot.2007.44
UR - https://doi.org/10.1038/nprot.2007.44
TI - The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
T2 - Nature Protocols
AU - Walf, Alicia A.
AU - Frye, Cheryl A
PY - 2007
DA - 2007/02/01
PB - Springer Nature
SP - 322-328
IS - 2
VL - 2
PMID - 17406592
SN - 1754-2189
SN - 1750-2799
ER -
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BibTex (up to 50 authors)
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@article{2007_Walf,
author = {Alicia A. Walf and Cheryl A Frye},
title = {The use of the elevated plus maze as an assay of anxiety-related behavior in rodents},
journal = {Nature Protocols},
year = {2007},
volume = {2},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038/nprot.2007.44},
number = {2},
pages = {322--328},
doi = {10.1038/nprot.2007.44}
}
Cite this
MLA
Copy
Walf, Alicia A., et al. “The use of the elevated plus maze as an assay of anxiety-related behavior in rodents.” Nature Protocols, vol. 2, no. 2, Feb. 2007, pp. 322-328. https://doi.org/10.1038/nprot.2007.44.