A time-of–drug addition approach to target identification of antiviral compounds
Тип публикации: Journal Article
Дата публикации: 2011-06-03
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 7.403
CiteScore: 31.3
Impact factor: 18.4
ISSN: 17542189, 17502799
PubMed ID:
21637207
General Biochemistry, Genetics and Molecular Biology
Краткое описание
Insight into the mode of action of newly discovered antiviral agents is now almost a prerequisite for clinical development. This protocol describes a method that provides information on the target of inhibitors of the human immunodeficiency virus (HIV); it can also be adapted to other viruses. The results from this experiment are available within 2 d. This time-based approach determines how long the addition of a compound can be postponed before losing its antiviral activity in cell culture. The target of an antiviral compound can be identified by comparing its relative position in the time scale to that of reference drugs. Therefore, it is more precise than, for example, in the case of HIV, a determination of pre- or postintegrational mode of action, and combines in one routine different assays for studying mechanisms of action.
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128
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128
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MLA
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ГОСТ
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Daelemans D. et al. A time-of–drug addition approach to target identification of antiviral compounds // Nature Protocols. 2011. Vol. 6. No. 6. pp. 925-933.
ГОСТ со всеми авторами (до 50)
Скопировать
Daelemans D., Pauwels R., De Clercq E., Pannecouque C. A time-of–drug addition approach to target identification of antiviral compounds // Nature Protocols. 2011. Vol. 6. No. 6. pp. 925-933.
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RIS
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TY - JOUR
DO - 10.1038/nprot.2011.330
UR - https://doi.org/10.1038/nprot.2011.330
TI - A time-of–drug addition approach to target identification of antiviral compounds
T2 - Nature Protocols
AU - Daelemans, Dirk
AU - Pauwels, Rudi
AU - De Clercq, Erik
AU - Pannecouque, Christophe
PY - 2011
DA - 2011/06/03
PB - Springer Nature
SP - 925-933
IS - 6
VL - 6
PMID - 21637207
SN - 1754-2189
SN - 1750-2799
ER -
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BibTex (до 50 авторов)
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@article{2011_Daelemans,
author = {Dirk Daelemans and Rudi Pauwels and Erik De Clercq and Christophe Pannecouque},
title = {A time-of–drug addition approach to target identification of antiviral compounds},
journal = {Nature Protocols},
year = {2011},
volume = {6},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1038/nprot.2011.330},
number = {6},
pages = {925--933},
doi = {10.1038/nprot.2011.330}
}
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MLA
Скопировать
Daelemans, Dirk, et al. “A time-of–drug addition approach to target identification of antiviral compounds.” Nature Protocols, vol. 6, no. 6, Jun. 2011, pp. 925-933. https://doi.org/10.1038/nprot.2011.330.
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