Targeting the mitogen-activated protein kinase cascade to treat cancer
1
Molecular Sciences and Technologies, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, USA
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Тип публикации: Journal Article
Дата публикации: 2004-12-01
scimago Q1
wos Q1
БС1
SJR: 24.378
CiteScore: 103.8
Impact factor: 66.8
ISSN: 1474175X, 14741768
PubMed ID:
15573115
General Environmental Science
General Earth and Planetary Sciences
Краткое описание
The RAS–mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central role in regulating the growth and survival of cells from a broad spectrum of human tumours. Small-molecule inhibitors designed to target various steps of this pathway have entered clinical trials. What have we recently learned about their safety and effectiveness? Will the MAPK pathway prove amenable to therapeutic intervention?
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ГОСТ
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Sebolt-Leopold J. S., Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer // Nature Reviews Cancer. 2004. Vol. 4. No. 12. pp. 937-947.
ГОСТ со всеми авторами (до 50)
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Sebolt-Leopold J. S., Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer // Nature Reviews Cancer. 2004. Vol. 4. No. 12. pp. 937-947.
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TY - JOUR
DO - 10.1038/nrc1503
UR - https://doi.org/10.1038/nrc1503
TI - Targeting the mitogen-activated protein kinase cascade to treat cancer
T2 - Nature Reviews Cancer
AU - Sebolt-Leopold, Judith S.
AU - Herrera, Roman
PY - 2004
DA - 2004/12/01
PB - Springer Nature
SP - 937-947
IS - 12
VL - 4
PMID - 15573115
SN - 1474-175X
SN - 1474-1768
ER -
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@article{2004_Sebolt-Leopold,
author = {Judith S. Sebolt-Leopold and Roman Herrera},
title = {Targeting the mitogen-activated protein kinase cascade to treat cancer},
journal = {Nature Reviews Cancer},
year = {2004},
volume = {4},
publisher = {Springer Nature},
month = {dec},
url = {https://doi.org/10.1038/nrc1503},
number = {12},
pages = {937--947},
doi = {10.1038/nrc1503}
}
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MLA
Скопировать
Sebolt-Leopold, Judith S., and Roman Herrera. “Targeting the mitogen-activated protein kinase cascade to treat cancer.” Nature Reviews Cancer, vol. 4, no. 12, Dec. 2004, pp. 937-947. https://doi.org/10.1038/nrc1503.