Targeting DNA topoisomerase II in cancer chemotherapy
Publication type: Journal Article
Publication date: 2009-04-20
scimago Q1
wos Q1
SJR: 24.378
CiteScore: 103.8
Impact factor: 66.8
ISSN: 1474175X, 14741768
DOI:
10.1038/nrc2607
PubMed ID:
19377506
General Environmental Science
General Earth and Planetary Sciences
Abstract
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.
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Metrics
1.5k
Total citations:
1510
Citations from 2024:
208
(13.79%)
Cite this
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GOST
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Nitiss J. L. Targeting DNA topoisomerase II in cancer chemotherapy // Nature Reviews Cancer. 2009. Vol. 9. No. 5. pp. 338-350.
GOST all authors (up to 50)
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Nitiss J. L. Targeting DNA topoisomerase II in cancer chemotherapy // Nature Reviews Cancer. 2009. Vol. 9. No. 5. pp. 338-350.
Cite this
RIS
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TY - JOUR
DO - 10.1038/nrc2607
UR - https://doi.org/10.1038/nrc2607
TI - Targeting DNA topoisomerase II in cancer chemotherapy
T2 - Nature Reviews Cancer
AU - Nitiss, John L
PY - 2009
DA - 2009/04/20
PB - Springer Nature
SP - 338-350
IS - 5
VL - 9
PMID - 19377506
SN - 1474-175X
SN - 1474-1768
ER -
Cite this
BibTex (up to 50 authors)
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@article{2009_Nitiss,
author = {John L Nitiss},
title = {Targeting DNA topoisomerase II in cancer chemotherapy},
journal = {Nature Reviews Cancer},
year = {2009},
volume = {9},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1038/nrc2607},
number = {5},
pages = {338--350},
doi = {10.1038/nrc2607}
}
Cite this
MLA
Copy
Nitiss, John L.. “Targeting DNA topoisomerase II in cancer chemotherapy.” Nature Reviews Cancer, vol. 9, no. 5, Apr. 2009, pp. 338-350. https://doi.org/10.1038/nrc2607.