Hypoxia — a key regulatory factor in tumour growth
1
Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
|
Publication type: Journal Article
Publication date: 2002-01-01
scimago Q1
wos Q1
SJR: 24.378
CiteScore: 103.8
Impact factor: 66.8
ISSN: 1474175X, 14741768
DOI:
10.1038/nrc704
PubMed ID:
11902584
General Environmental Science
General Earth and Planetary Sciences
Abstract
Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have adapted these pathways, allowing tumours to survive and even grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and resistance to radiation therapy. Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting.
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RIS
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TY - JOUR
DO - 10.1038/nrc704
UR - https://doi.org/10.1038/nrc704
TI - Hypoxia — a key regulatory factor in tumour growth
T2 - Nature Reviews Cancer
AU - Harris, Adrian L.
PY - 2002
DA - 2002/01/01
PB - Springer Nature
SP - 38-47
IS - 1
VL - 2
PMID - 11902584
SN - 1474-175X
SN - 1474-1768
ER -
Cite this
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@article{2002_Harris,
author = {Adrian L. Harris},
title = {Hypoxia — a key regulatory factor in tumour growth},
journal = {Nature Reviews Cancer},
year = {2002},
volume = {2},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1038/nrc704},
number = {1},
pages = {38--47},
doi = {10.1038/nrc704}
}
Cite this
MLA
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Harris, Adrian L.. “Hypoxia — a key regulatory factor in tumour growth.” Nature Reviews Cancer, vol. 2, no. 1, Jan. 2002, pp. 38-47. https://doi.org/10.1038/nrc704.