Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
Тип публикации: Journal Article
Дата публикации: 2007-05-01
scimago Q1
wos Q1
БС1
SJR: 30.506
CiteScore: 181.8
Impact factor: 101.8
ISSN: 14741776, 14741784
PubMed ID:
17464296
Drug Discovery
General Medicine
Pharmacology
Краткое описание
Endogenous polyamines are essential for cell growth and are known to be dysregulated in cancer and other diseases. Here the potential strategies for modulating polyamine metabolism and function are reviewed with a focus on the use of synthetic polyamine analogues. The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.
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Casero R. A., Marton L. J. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases // Nature Reviews Drug Discovery. 2007. Vol. 6. No. 5. pp. 373-390.
ГОСТ со всеми авторами (до 50)
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Casero R. A., Marton L. J. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases // Nature Reviews Drug Discovery. 2007. Vol. 6. No. 5. pp. 373-390.
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TY - JOUR
DO - 10.1038/nrd2243
UR - https://doi.org/10.1038/nrd2243
TI - Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
T2 - Nature Reviews Drug Discovery
AU - Casero, Robert A.
AU - Marton, Laurence J.
PY - 2007
DA - 2007/05/01
PB - Springer Nature
SP - 373-390
IS - 5
VL - 6
PMID - 17464296
SN - 1474-1776
SN - 1474-1784
ER -
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@article{2007_Casero,
author = {Robert A. Casero and Laurence J. Marton},
title = {Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases},
journal = {Nature Reviews Drug Discovery},
year = {2007},
volume = {6},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1038/nrd2243},
number = {5},
pages = {373--390},
doi = {10.1038/nrd2243}
}
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MLA
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Casero, Robert A., and Laurence J. Marton. “Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.” Nature Reviews Drug Discovery, vol. 6, no. 5, May. 2007, pp. 373-390. https://doi.org/10.1038/nrd2243.