Open Access
Nature Reviews Drug Discovery, volume 10, issue 3, pages 221-237
Cell death assays for drug discovery
Kepp Oliver
1, 2, 3
,
Galluzzi Lorenzo
1, 2, 3
,
Lipinski Marta
4
,
Yuan Junying
4
,
Kroemer Guido
1, 2
1
INSERM, U848, France
|
2
Institut Gustave Roussy, France
|
3
Universit Paris-Sud, France
|
4
Department of Cell Biology, Harvard Medical School, Boston, USA
|
Publication type: Journal Article
Publication date: 2011-03-03
Journal:
Nature Reviews Drug Discovery
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 120.1
ISSN: 14741776, 14741784
DOI:
10.1038/nrd3373
Drug Discovery
General Medicine
Pharmacology
Abstract
Cell death has an important role in many human diseases, and strategies aimed at modulating the associated pathways have been successfully applied to treat various disorders. Indeed, several clinically promising cytotoxic and cytoprotective agents with potential applications in cancer, ischaemic and neurodegenerative diseases have recently been identified by high-throughput screening (HTS), based on appropriate cell death assays. Given that different cell death modalities may be dysregulated in different diseases, it is becoming increasingly clear that such assays need to not only quantify the extent of cell death, but they must also be able to distinguish between the various pathways. Here, we systematically describe approaches to accurately quantify distinct cell death pathways, discuss their advantages and pitfalls, and focus on those techniques that are amenable to HTS.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Kepp O. et al. Cell death assays for drug discovery // Nature Reviews Drug Discovery. 2011. Vol. 10. No. 3. pp. 221-237.
GOST all authors (up to 50)
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Kepp O., Galluzzi L., Lipinski M., Yuan J., Kroemer G. Cell death assays for drug discovery // Nature Reviews Drug Discovery. 2011. Vol. 10. No. 3. pp. 221-237.
Cite this
RIS
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TY - JOUR
DO - 10.1038/nrd3373
UR - https://doi.org/10.1038%2Fnrd3373
TI - Cell death assays for drug discovery
T2 - Nature Reviews Drug Discovery
AU - Kepp, Oliver
AU - Galluzzi, Lorenzo
AU - Lipinski, Marta
AU - Yuan, Junying
AU - Kroemer, Guido
PY - 2011
DA - 2011/03/03 00:00:00
PB - Springer Nature
SP - 221-237
IS - 3
VL - 10
SN - 1474-1776
SN - 1474-1784
ER -
Cite this
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@article{2011_Kepp,
author = {Oliver Kepp and Lorenzo Galluzzi and Marta Lipinski and Junying Yuan and Guido Kroemer},
title = {Cell death assays for drug discovery},
journal = {Nature Reviews Drug Discovery},
year = {2011},
volume = {10},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038%2Fnrd3373},
number = {3},
pages = {221--237},
doi = {10.1038/nrd3373}
}
Cite this
MLA
Copy
Kepp, Oliver, et al. “Cell death assays for drug discovery.” Nature Reviews Drug Discovery, vol. 10, no. 3, Mar. 2011, pp. 221-237. https://doi.org/10.1038%2Fnrd3373.