Nature Reviews Molecular Cell Biology, volume 17, issue 6, pages 379-394
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Publication type: Journal Article
Publication date: 2016-05-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 112.7
ISSN: 14710072, 14710080
Molecular Biology
Cell Biology
Abstract
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition and faithful repair of such damage is crucial for the maintenance of genomic stability, as well as for cell and organismal fitness. Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs) orchestrates and regulates cellular responses to DSBs at multiple levels, often involving extensive crosstalk between these modifications. Recent findings have revealed compelling insights into the complex mechanisms by which ubiquitin and UBLs regulate protein interactions with DSB sites to promote accurate lesion repair and protection of genome integrity in mammalian cells. These advances offer new therapeutic opportunities for diseases linked to genetic instability.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Schwertman P., Bekker-Jensen S., Mailand N. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 6. pp. 379-394.
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Schwertman P., Bekker-Jensen S., Mailand N. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 6. pp. 379-394.
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TY - JOUR
DO - 10.1038/nrm.2016.58
UR - https://doi.org/10.1038%2Fnrm.2016.58
TI - Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
T2 - Nature Reviews Molecular Cell Biology
AU - Schwertman, Petra
AU - Bekker-Jensen, Simon
AU - Mailand, Niels
PY - 2016
DA - 2016/05/23 00:00:00
PB - Springer Nature
SP - 379-394
IS - 6
VL - 17
SN - 1471-0072
SN - 1471-0080
ER -
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@article{2016_Schwertman,
author = {Petra Schwertman and Simon Bekker-Jensen and Niels Mailand},
title = {Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers},
journal = {Nature Reviews Molecular Cell Biology},
year = {2016},
volume = {17},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1038%2Fnrm.2016.58},
number = {6},
pages = {379--394},
doi = {10.1038/nrm.2016.58}
}
Cite this
MLA
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Schwertman, Petra, et al. “Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.” Nature Reviews Molecular Cell Biology, vol. 17, no. 6, May. 2016, pp. 379-394. https://doi.org/10.1038%2Fnrm.2016.58.