Histone exchange, chromatin structure and the regulation of transcription
Тип публикации: Journal Article
Дата публикации: 2015-02-04
scimago Q1
wos Q1
БС1
SJR: 37.353
CiteScore: 150.9
Impact factor: 90.2
ISSN: 14710072, 14710080
PubMed ID:
25650798
Molecular Biology
Cell Biology
Краткое описание
The packaging of DNA into strings of nucleosomes is one of the features that allows eukaryotic cells to tightly regulate gene expression. The ordered disassembly of nucleosomes permits RNA polymerase II (Pol II) to access the DNA, whereas nucleosomal reassembly impedes access, thus preventing transcription and mRNA synthesis. Chromatin modifications, chromatin remodellers, histone chaperones and histone variants regulate nucleosomal dynamics during transcription. Disregulation of nucleosome dynamics results in aberrant transcription initiation, producing non-coding RNAs. Ongoing research is elucidating the molecular mechanisms that regulate chromatin structure during transcription by preventing histone exchange, thereby limiting non-coding RNA expression.
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ГОСТ
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Swaminathan V., Workman J. L. Histone exchange, chromatin structure and the regulation of transcription // Nature Reviews Molecular Cell Biology. 2015. Vol. 16. No. 3. pp. 178-189.
ГОСТ со всеми авторами (до 50)
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Swaminathan V., Workman J. L. Histone exchange, chromatin structure and the regulation of transcription // Nature Reviews Molecular Cell Biology. 2015. Vol. 16. No. 3. pp. 178-189.
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RIS
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TY - JOUR
DO - 10.1038/nrm3941
UR - https://doi.org/10.1038/nrm3941
TI - Histone exchange, chromatin structure and the regulation of transcription
T2 - Nature Reviews Molecular Cell Biology
AU - Swaminathan, Venkatesh
AU - Workman, Jerry L.
PY - 2015
DA - 2015/02/04
PB - Springer Nature
SP - 178-189
IS - 3
VL - 16
PMID - 25650798
SN - 1471-0072
SN - 1471-0080
ER -
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BibTex (до 50 авторов)
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@article{2015_Swaminathan,
author = {Venkatesh Swaminathan and Jerry L. Workman},
title = {Histone exchange, chromatin structure and the regulation of transcription},
journal = {Nature Reviews Molecular Cell Biology},
year = {2015},
volume = {16},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038/nrm3941},
number = {3},
pages = {178--189},
doi = {10.1038/nrm3941}
}
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MLA
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Swaminathan, Venkatesh, and Jerry L. Workman. “Histone exchange, chromatin structure and the regulation of transcription.” Nature Reviews Molecular Cell Biology, vol. 16, no. 3, Feb. 2015, pp. 178-189. https://doi.org/10.1038/nrm3941.