, volume 30 , issue 4

Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules

Onsurang Wattanathamsan ^{1, 2}

Varisa Pongrakhananon ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals Research Cluster, Chulalongkorn University, Bangkok, Thailand |

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand |

Publication type: Journal Article

Publication date: 2021-10-20

Springer Nature

Cancer Gene Therapy

scimago Q1

wos Q1

SJR: 1.727

CiteScore: 10.9

Impact factor: 5.0

ISSN: 09291903, 14765500

DOI: 10.1038/s41417-021-00396-4

Copy DOI

PubMed ID: 34671113

Cancer Research

Molecular Biology

Molecular Medicine

Abstract

Microtubules play an important role in regulating several vital cellular activities, including cell division and tissue organization, through their dynamic protofilament network. In addition to forming the cytoskeleton, microtubules regulate the intracellular trafficking of cytoplasmic components and various signaling molecules, depending on the presence of post-transitional modifications (PTMs) and binding proteins. Accumulating evidence indicates the significant role of microtubule PTMs on cancer behavior. The PTMs that frequently occur on microtubules include acetylation, detyrosination, tyrosination, polyglutamylation, and polyglycylation. Alterations in these PTMs cause global effects on intracellular signal transduction, strongly linked to cancer pathogenesis. This review provides an update on the role of microtubule PTMs in cancer aggressiveness, particularly regarding cell death, sensitivity to chemotherapy, cell migration, and invasion. Additionally, it provides a mechanistic explanation of the molecular signaling pathways involved. This information might prove useful for predictive or therapeutic purposes.

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GOST Copy

Wattanathamsan O. et al. Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules // Cancer Gene Therapy. 2021. Vol. 30. No. 4.

GOST all authors (up to 50) Copy

Wattanathamsan O., Pongrakhananon V. Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules // Cancer Gene Therapy. 2021. Vol. 30. No. 4.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41417-021-00396-4

UR - https://doi.org/10.1038/s41417-021-00396-4

TI - Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules

T2 - Cancer Gene Therapy

AU - Wattanathamsan, Onsurang

AU - Pongrakhananon, Varisa

PY - 2021

DA - 2021/10/20

PB - Springer Nature

IS - 4

VL - 30

PMID - 34671113

SN - 0929-1903

SN - 1476-5500

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Wattanathamsan,

author = {Onsurang Wattanathamsan and Varisa Pongrakhananon},

title = {Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules},

journal = {Cancer Gene Therapy},

year = {2021},

volume = {30},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1038/s41417-021-00396-4},

number = {4},

doi = {10.1038/s41417-021-00396-4}

}

Publisher

Springer Nature

Journal

Cancer Gene Therapy

scimago Q1

wos Q1

SJR

1.727

CiteScore

10.9

Impact factor

5.0

ISSN

09291903 (Print)

14765500 (Electronic)