Open Access
Nature Communications, volume 9, issue 1, publication number 3223
Single-molecule detection with a millimetre-sized transistor
Eleonora Macchia
1
,
Kyriaki Manoli
1
,
Brigitte Holzer
1
,
Cinzia Di Franco
2
,
Matteo Ghittorelli
3
,
Fabrizio Torricelli
3
,
Domenico Alberga
4
,
Giuseppe Felice Mangiatordi
4, 5
,
Gerardo Palazzo
1, 6
,
Gaetano Scamarcio
2, 7
,
L. Torsi
1, 6, 8
3
6
CSGI (Centre for Colloid and Surface Science), 70125 Bari, Italy
|
7
Publication type: Journal Article
Publication date: 2018-08-13
Journal:
Nature Communications
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 16.6
ISSN: 20411723, 20411723
PubMed ID:
30104563
General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy
Abstract
Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into a sequence of single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense a cue in a bulk milieu. Conceptualizing cells’ ability to sense at the physical limit by means of highly-packed recognition elements, a millimetric sized field-effect-transistor is used to detect a single molecule. To this end, the gate is bio-functionalized with a self-assembled-monolayer of 1012 capturing anti-Immunoglobulin-G and is endowed with a hydrogen-bonding network enabling cooperative interactions. The selective and label-free single molecule IgG detection is strikingly demonstrated in diluted saliva while 15 IgGs are assayed in whole serum. The suggested sensing mechanism, triggered by the affinity binding event, involves a work-function change that is assumed to propagate in the gating-field through the electrostatic hydrogen-bonding network. The proposed immunoassay platform is general and can revolutionize the current approach to protein detection.The sensing capability of nanometric transducers designed for label-free single molecule detection has been limited by the small number of recognition elements. Here, the authors demonstrate a millimetre-sized field effect transistor capable of selective single-molecule Immunoglobulin-G detection.
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Citations by publishers
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Wiley
53 publications, 27.75%
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33 publications, 17.28%
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2 publications, 1.05%
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American Physical Society (APS)
1 publication, 0.52%
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American Vacuum Society
1 publication, 0.52%
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Frontiers Media S.A.
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Cambridge University Press
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1 publication, 0.52%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Macchia E. et al. Single-molecule detection with a millimetre-sized transistor // Nature Communications. 2018. Vol. 9. No. 1. 3223
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Macchia E., Manoli K., Holzer B., Di Franco C., Ghittorelli M., Torricelli F., Alberga D., Mangiatordi G. F., Palazzo G., Scamarcio G., Torsi L. Single-molecule detection with a millimetre-sized transistor // Nature Communications. 2018. Vol. 9. No. 1. 3223
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TY - JOUR
DO - 10.1038/s41467-018-05235-z
UR - https://doi.org/10.1038/s41467-018-05235-z
TI - Single-molecule detection with a millimetre-sized transistor
T2 - Nature Communications
AU - Macchia, Eleonora
AU - Manoli, Kyriaki
AU - Holzer, Brigitte
AU - Di Franco, Cinzia
AU - Ghittorelli, Matteo
AU - Torricelli, Fabrizio
AU - Alberga, Domenico
AU - Mangiatordi, Giuseppe Felice
AU - Palazzo, Gerardo
AU - Scamarcio, Gaetano
AU - Torsi, L.
PY - 2018
DA - 2018/08/13 00:00:00
PB - Springer Nature
IS - 1
VL - 9
PMID - 30104563
SN - 2041-1723
SN - 2041-1723
ER -
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@article{2018_Macchia,
author = {Eleonora Macchia and Kyriaki Manoli and Brigitte Holzer and Cinzia Di Franco and Matteo Ghittorelli and Fabrizio Torricelli and Domenico Alberga and Giuseppe Felice Mangiatordi and Gerardo Palazzo and Gaetano Scamarcio and L. Torsi},
title = {Single-molecule detection with a millimetre-sized transistor},
journal = {Nature Communications},
year = {2018},
volume = {9},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038/s41467-018-05235-z},
number = {1},
doi = {10.1038/s41467-018-05235-z}
}