Open Access

Nature Communications

, том 14 , издание 1 , номер публикации 149

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

Тип публикации: Journal Article

Дата публикации: 2023-01-10

Springer Nature

Nature Communications

scimago Q1

wos Q1

БС1

SJR: 4.761

CiteScore: 23.4

Impact factor: 15.7

ISSN: 20411723

DOI: 10.1038/s41467-022-34033-x

Скопировать DOI

PubMed ID: 36627290

General Chemistry

General Biochemistry, Genetics and Molecular Biology

Multidisciplinary

General Physics and Astronomy

Краткое описание

Evolution of SARS-CoV-2 in immunocompromised hosts may result in novel variants with changed properties. While escape from humoral immunity certainly contributes to intra-host evolution, escape from cellular immunity is poorly understood. Here, we report a case of long-term COVID-19 in an immunocompromised patient with non-Hodgkin’s lymphoma who received treatment with rituximab and lacked neutralizing antibodies. Over the 318 days of the disease, the SARS-CoV-2 genome gained a total of 40 changes, 34 of which were present by the end of the study period. Among the acquired mutations, 12 reduced or prevented the binding of known immunogenic SARS-CoV-2 HLA class I antigens. By experimentally assessing the effect of a subset of the escape mutations, we show that they resulted in a loss of as much as ~1% of effector CD8 T cell response. Our results indicate that CD8 T cell escape represents a major underappreciated contributor to SARS-CoV-2 evolution in humans.

Найдено

2 цитирования

Боголюбова Аполлинария

к.б.н.

38 публикаций, 182 цитирования, 2 рецензии

Индекс Хирша: 9

Национальный медицинский исследовательский центр гематологии

1 цитирование

Коробова Зоя

🤝

к.м.н.

33 публикации, 283 цитирования

Индекс Хирша: 10

Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера

Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова

Области научных интересов

Иммунология

Цитокины

Топ-30

Журналы

	1 2 3 4 5 6
Frontiers in Immunology	Frontiers in Immunology, 6, 13.64% Frontiers in Immunology 6 публикаций, 13.64%
Viruses	Viruses, 3, 6.82% Viruses 3 публикации, 6.82%
Journal of Medical Virology	Journal of Medical Virology, 2, 4.55% Journal of Medical Virology 2 публикации, 4.55%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 4.55% International Journal of Molecular Sciences 2 публикации, 4.55%
iScience	iScience, 2, 4.55% iScience 2 публикации, 4.55%
PLoS Pathogens	PLoS Pathogens, 2, 4.55% PLoS Pathogens 2 публикации, 4.55%
HIV Infection and Immunosuppressive Disorders	HIV Infection and Immunosuppressive Disorders, 2, 4.55% HIV Infection and Immunosuppressive Disorders 2 публикации, 4.55%
Nature Communications	Nature Communications, 2, 4.55% Nature Communications 2 публикации, 4.55%
Cell Reports	Cell Reports, 1, 2.27% Cell Reports 1 публикация, 2.27%
medRxiv : the preprint server for health sciences	medRxiv : the preprint server for health sciences, 1, 2.27% medRxiv : the preprint server for health sciences 1 публикация, 2.27%
Journal of Infectious Diseases	Journal of Infectious Diseases, 1, 2.27% Journal of Infectious Diseases 1 публикация, 2.27%
mBio	mBio, 1, 2.27% mBio 1 публикация, 2.27%
Open Forum Infectious Diseases	Open Forum Infectious Diseases, 1, 2.27% Open Forum Infectious Diseases 1 публикация, 2.27%
Immunotherapy Advances	Immunotherapy Advances, 1, 2.27% Immunotherapy Advances 1 публикация, 2.27%
EBioMedicine	EBioMedicine, 1, 2.27% EBioMedicine 1 публикация, 2.27%
Life	Life, 1, 2.27% Life 1 публикация, 2.27%
Nature Reviews Microbiology	Nature Reviews Microbiology, 1, 2.27% Nature Reviews Microbiology 1 публикация, 2.27%
Nature Immunology	Nature Immunology, 1, 2.27% Nature Immunology 1 публикация, 2.27%
Virology Journal	Virology Journal, 1, 2.27% Virology Journal 1 публикация, 2.27%
European Journal of Immunology	European Journal of Immunology, 1, 2.27% European Journal of Immunology 1 публикация, 2.27%
PLoS Computational Biology	PLoS Computational Biology, 1, 2.27% PLoS Computational Biology 1 публикация, 2.27%
Mathematical Biosciences	Mathematical Biosciences, 1, 2.27% Mathematical Biosciences 1 публикация, 2.27%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 2.27% Frontiers in Cellular and Infection Microbiology 1 публикация, 2.27%
Immunological Medicine	Immunological Medicine, 1, 2.27% Immunological Medicine 1 публикация, 2.27%
	1 2 3 4 5 6

Издатели

	1 2 3 4 5 6 7
Frontiers Media S.A.	Frontiers Media S.A., 7, 15.91% Frontiers Media S.A. 7 публикаций, 15.91%
Elsevier	Elsevier, 6, 13.64% Elsevier 6 публикаций, 13.64%
MDPI	MDPI, 6, 13.64% MDPI 6 публикаций, 13.64%
Springer Nature	Springer Nature, 5, 11.36% Springer Nature 5 публикаций, 11.36%
Wiley	Wiley, 3, 6.82% Wiley 3 публикации, 6.82%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 3, 6.82% Cold Spring Harbor Laboratory 3 публикации, 6.82%
Oxford University Press	Oxford University Press, 3, 6.82% Oxford University Press 3 публикации, 6.82%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 6.82% Public Library of Science (PLoS) 3 публикации, 6.82%
Baltic Medical Education Center	Baltic Medical Education Center, 2, 4.55% Baltic Medical Education Center 2 публикации, 4.55%
American Society for Microbiology	American Society for Microbiology, 1, 2.27% American Society for Microbiology 1 публикация, 2.27%
Taylor & Francis	Taylor & Francis, 1, 2.27% Taylor & Francis 1 публикация, 2.27%
	1 2 3 4 5 6 7

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

PDF

Метрики

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Stanevich O. V. et al. SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19 // Nature Communications. 2023. Vol. 14. No. 1. 149

ГОСТ со всеми авторами (до 50) Скопировать

Stanevich O. V., Alekseeva E. I., Sergeeva M. V., Fadeev A. V., Komissarova K. S., Ivanova A. A., Simakova T., Vasiliev K. A., Shurygina A. P., Stukova M. A., Safina K. R., Nabieva E. R., Garushyants S. K., Klink G. V., Bakin E. A., Zabutova J. V., Kholodnaia A. N., Lukina O. V., Skorokhod I. A., Ryabchikova V. V., Medvedeva N. V., Lioznov D. A., Danilenko D., Chudakov D. M., Komissarov A. B., Bazykin G. A. SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19 // Nature Communications. 2023. Vol. 14. No. 1. 149

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.1038/s41467-022-34033-x

UR - https://doi.org/10.1038/s41467-022-34033-x

TI - SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

T2 - Nature Communications

AU - Stanevich, Oksana V

AU - Alekseeva, Evgeniia I

AU - Sergeeva, Maria V

AU - Fadeev, Artem V

AU - Komissarova, Kseniya S

AU - Ivanova, Anna A

AU - Simakova, Tamara

AU - Vasiliev, Kirill A

AU - Shurygina, Anna Polina

AU - Stukova, Marina A

AU - Safina, Ksenia R

AU - Nabieva, Elena R

AU - Garushyants, Sofya K

AU - Klink, Galya V.

AU - Bakin, Evgeny A

AU - Zabutova, Jullia V

AU - Kholodnaia, Anastasia N

AU - Lukina, Olga V

AU - Skorokhod, Irina A

AU - Ryabchikova, Viktoria V

AU - Medvedeva, Nadezhda V

AU - Lioznov, Dmitry A

AU - Danilenko, Daria

AU - Chudakov, Dmitry M.

AU - Komissarov, Andrey B

AU - Bazykin, Georgii A.

PY - 2023

DA - 2023/01/10

PB - Springer Nature

IS - 1

VL - 14

PMID - 36627290

SN - 2041-1723

ER -

BibTex

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2023_Stanevich,

author = {Oksana V Stanevich and Evgeniia I Alekseeva and Maria V Sergeeva and Artem V Fadeev and Kseniya S Komissarova and Anna A Ivanova and Tamara Simakova and Kirill A Vasiliev and Anna Polina Shurygina and Marina A Stukova and Ksenia R Safina and Elena R Nabieva and Sofya K Garushyants and Galya V. Klink and Evgeny A Bakin and Jullia V Zabutova and Anastasia N Kholodnaia and Olga V Lukina and Irina A Skorokhod and Viktoria V Ryabchikova and Nadezhda V Medvedeva and Dmitry A Lioznov and Daria Danilenko and Dmitry M. Chudakov and Andrey B Komissarov and Georgii A. Bazykin},

title = {SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19},

journal = {Nature Communications},

year = {2023},

volume = {14},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038/s41467-022-34033-x},

number = {1},

pages = {149},

doi = {10.1038/s41467-022-34033-x}

}

Издатель

Springer Nature

Журнал

Nature Communications

scimago Q1

wos Q1

БС1

SJR

4.761

CiteScore

23.4

Impact factor

15.7

ISSN

20411723 (Print, Electronic)

Профили

Чудаков Дмитрий Михайлович

Новости

Оставшись наедине с Т-лимфоцитами, коронавирус стал «супервирусом»