Nature Reviews Genetics, volume 20, issue 5, pages 299-309
Telomeres and telomerase: three decades of progress
1
Department of Cell Biology, UT Southwestern Medical Center, Dallas, USA
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Publication type: Journal Article
Publication date: 2019-02-13
Journal:
Nature Reviews Genetics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 42.7
ISSN: 14710056, 14710064
Molecular Biology
Genetics
Genetics (clinical)
Abstract
Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the mechanistic underpinnings of telomeres and telomerase and their roles in ageing and disease. Three decades ago, the classic view was that telomeres protected the natural ends of linear chromosomes and that telomerase was a specific telomere-terminal transferase necessary for the replication of chromosome ends in single-celled organisms. While this concept is still correct, many diverse fields associated with telomeres and telomerase have substantially matured. These areas include the discovery of most of the key molecular components of telomerase, implications for limits to cellular replication, identification and characterization of human genetic disorders that result in premature telomere shortening, the concept that inhibiting telomerase might be a successful therapeutic strategy and roles for telomeres in regulating gene expression. We discuss progress in these areas and conclude with challenges and unanswered questions in the field.In this Timeline article, Shay and Wright provide a historical account of progress in our understanding of telomeres (the ends of linear chromosomes) and telomerase (the primary enzyme that maintains and extends telomere lengths). Their perspective covers seminal moments from the early discoveries through to our latest understanding of the roles of telomeres and telomerase in ageing, diverse human diseases and gene regulation.
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Shy J. W., Wright W. E. Telomeres and telomerase: three decades of progress // Nature Reviews Genetics. 2019. Vol. 20. No. 5. pp. 299-309.
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Shy J. W., Wright W. E. Telomeres and telomerase: three decades of progress // Nature Reviews Genetics. 2019. Vol. 20. No. 5. pp. 299-309.
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TY - JOUR
DO - 10.1038/s41576-019-0099-1
UR - https://doi.org/10.1038%2Fs41576-019-0099-1
TI - Telomeres and telomerase: three decades of progress
T2 - Nature Reviews Genetics
AU - Shy, J. W.
AU - Wright, Woodring E
PY - 2019
DA - 2019/02/13 00:00:00
PB - Springer Nature
SP - 299-309
IS - 5
VL - 20
SN - 1471-0056
SN - 1471-0064
ER -
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@article{2019_Shy,
author = {J. W. Shy and Woodring E Wright},
title = {Telomeres and telomerase: three decades of progress},
journal = {Nature Reviews Genetics},
year = {2019},
volume = {20},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1038%2Fs41576-019-0099-1},
number = {5},
pages = {299--309},
doi = {10.1038/s41576-019-0099-1}
}
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MLA
Copy
Shy, J. W., and Woodring E Wright. “Telomeres and telomerase: three decades of progress.” Nature Reviews Genetics, vol. 20, no. 5, Feb. 2019, pp. 299-309. https://doi.org/10.1038%2Fs41576-019-0099-1.