Nature Biotechnology

, том 41 , издание 5

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Yuanwen Jiang ¹

Artem A. Trotsyuk ^{2, 3}

Simiao Niu ¹

Dominic Henn ²

Kellen Chen ^{2, 3}

Chien-Chung Shih ¹

Madelyn R. Larson ²

Alana M Mermin Bunnell ²

Smiti Mittal ²

Jian Cheng Lai ¹

Aref Saberi ¹

Ethan Beard ²

Serena Jing ²

Donglai Zhong ¹

Sydney R. Steele ²

Kefan Sun ¹

Tanish Jain ²

Eric Zhao ¹

Christopher R Neimeth ²

Willian G Viana ⁴

Jing Tang ^{1, 5}

Dharshan Sivaraj ^{2, 3}

Jagannath Padmanabhan ²

Melanie Rodrigues ²

David P. Perrault ²

Arhana Chattopadhyay ²

Zeshaan N. Maan ²

Melissa C. Leeolou ²

Clark A. Bonham ²

Sun Hyung Kwon ²

Hudson C. Kussie ^{2, 3}

Katharina S. Fischer ^{2, 3}

Gurupranav Gurusankar ¹

Kui Liang ⁶

Zhang Kailiang ⁶

Ronjon Nag ⁷

Michael P. Snyder ⁸

Michael Januszyk ²

Geoffrey C. Gurtner ^{2, 3}

Zhenan Bao ¹

Скрыть аффилиации авторов Показать аффилиации авторов: 8 аффилиаций

Department of Chemical Engineering, Stanford University, Stanford, USA |

Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, USA |

Department of Surgery, University of Arizona College of Medicine, Tucson, USA |

⁴

Department of Biology, Stanford University, Stanford, USA |

⁵

Department of Materials science and engineering, Stanford University, Stanford, USA |

⁶

BOE Technology Center, BOE Technology Group CO., Ltd, Beijing, China |

⁷

Stanford Distinguished Careers Institute, Stanford University, Stanford, USA |

⁸

Department of Genetics, Stanford University School of Medicine, Stanford, USA |

Тип публикации: Journal Article

Дата публикации: 2022-11-24

Springer Nature

Nature Biotechnology

scimago Q1

wos Q1

БС1

SJR: 19.006

CiteScore: 58.8

Impact factor: 41.7

ISSN: 10870156, 15461696

DOI: 10.1038/s41587-022-01528-3

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PubMed ID: 36424488

Molecular Medicine

Applied Microbiology and Biotechnology

Biotechnology

Bioengineering

Biomedical Engineering

Краткое описание

‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery. A wireless ‘smart’ bandage stimulates wound healing.

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Jiang Y. et al. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing // Nature Biotechnology. 2022. Vol. 41. No. 5.

ГОСТ со всеми авторами (до 50) Скопировать

Jiang Y., Trotsyuk A. A., Niu S., Henn D., Chen K., Shih C., Larson M. R., Mermin Bunnell A. M., Mittal S., Lai J. C., Saberi A., Beard E., Jing S., Zhong D., Steele S. R., Sun K., Jain T., Zhao E., Neimeth C. R., Viana W. G., Tang J., Sivaraj D., Padmanabhan J., Rodrigues M., Perrault D. P., Chattopadhyay A., Maan Z. N., Leeolou M. C., Bonham C. A., Kwon S. H., Kussie H. C., Fischer K. S., Gurusankar G., Liang K., Kailiang Z., Nag R., Snyder M. P., Januszyk M., Gurtner G. C., Bao Z. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing // Nature Biotechnology. 2022. Vol. 41. No. 5.

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TY - JOUR

DO - 10.1038/s41587-022-01528-3

UR - https://doi.org/10.1038/s41587-022-01528-3

TI - Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

T2 - Nature Biotechnology

AU - Jiang, Yuanwen

AU - Trotsyuk, Artem A.

AU - Niu, Simiao

AU - Henn, Dominic

AU - Chen, Kellen

AU - Shih, Chien-Chung

AU - Larson, Madelyn R.

AU - Mermin Bunnell, Alana M

AU - Mittal, Smiti

AU - Lai, Jian Cheng

AU - Saberi, Aref

AU - Beard, Ethan

AU - Jing, Serena

AU - Zhong, Donglai

AU - Steele, Sydney R.

AU - Sun, Kefan

AU - Jain, Tanish

AU - Zhao, Eric

AU - Neimeth, Christopher R

AU - Viana, Willian G

AU - Tang, Jing

AU - Sivaraj, Dharshan

AU - Padmanabhan, Jagannath

AU - Rodrigues, Melanie

AU - Perrault, David P.

AU - Chattopadhyay, Arhana

AU - Maan, Zeshaan N.

AU - Leeolou, Melissa C.

AU - Bonham, Clark A.

AU - Kwon, Sun Hyung

AU - Kussie, Hudson C.

AU - Fischer, Katharina S.

AU - Gurusankar, Gurupranav

AU - Liang, Kui

AU - Kailiang, Zhang

AU - Nag, Ronjon

AU - Snyder, Michael P.

AU - Januszyk, Michael

AU - Gurtner, Geoffrey C.

AU - Bao, Zhenan

PY - 2022

DA - 2022/11/24

PB - Springer Nature

IS - 5

VL - 41

PMID - 36424488

SN - 1087-0156

SN - 1546-1696

ER -

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@article{2022_Jiang,

author = {Yuanwen Jiang and Artem A. Trotsyuk and Simiao Niu and Dominic Henn and Kellen Chen and Chien-Chung Shih and Madelyn R. Larson and Alana M Mermin Bunnell and Smiti Mittal and Jian Cheng Lai and Aref Saberi and Ethan Beard and Serena Jing and Donglai Zhong and Sydney R. Steele and Kefan Sun and Tanish Jain and Eric Zhao and Christopher R Neimeth and Willian G Viana and Jing Tang and Dharshan Sivaraj and Jagannath Padmanabhan and Melanie Rodrigues and David P. Perrault and Arhana Chattopadhyay and Zeshaan N. Maan and Melissa C. Leeolou and Clark A. Bonham and Sun Hyung Kwon and Hudson C. Kussie and Katharina S. Fischer and Gurupranav Gurusankar and Kui Liang and Zhang Kailiang and Ronjon Nag and Michael P. Snyder and Michael Januszyk and Geoffrey C. Gurtner and Zhenan Bao},

title = {Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing},

journal = {Nature Biotechnology},

year = {2022},

volume = {41},

publisher = {Springer Nature},

month = {nov},

url = {https://doi.org/10.1038/s41587-022-01528-3},

number = {5},

doi = {10.1038/s41587-022-01528-3}

}

Издатель

Springer Nature

Журнал

Nature Biotechnology

scimago Q1

wos Q1

БС1

SJR

19.006

CiteScore

58.8

Impact factor

41.7

ISSN

10870156 (Print)

15461696 (Electronic)

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Бао Женан