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CAVE: Connectome Annotation Versioning Engine

Sven Dorkenwald 1, 2
Casey Schneider Mizell 3
DERRICK BRITTAIN 3
Akhilesh Halageri 1
Chris Jordan 1
Nico Kemnitz 1
Manual A. Castro 1
William Silversmith 1
Jeremy Maitin-Shephard 4
Jakob Troidl 5
Hanspeter Pfister 5
Valentin Gillet 6
Daniel Xenes 7
J Alexander Bae 1, 8
Agnes L Bodor 3
Joann Buchanan 3
Daniel J. Bumbarger 3
Leila Elabbady 3
Zhen Jia 1, 2
Daniel Kapner 3
Sam Kinn 3
Kisuk Lee 1, 9
Kai Li 2
Lu Ran 1
Thomas Macrina 1, 2
Gayathri Mahalingam 3
Eric Mitchell 1
Shanka Subhra Mondal 1, 8
Mu Shang 1
Barak Nehoran 1, 2
Sergiy Popovych 1, 2
Marc Takeno 3
Russel Torres 3
Nicholas L Turner 1, 2
William Wong 1
Jingpeng Wu 1
Wenjing Yin 3
Szi-chieh Yu 1
R. J. O. Reid 3
Nuno Maçarico Da Costa 3
H. Sebastian Seung 1, 2
F. Collman 3
Тип публикацииJournal Article
Дата публикации2025-04-09
scimago Q1
wos Q1
БС1
SJR17.251
CiteScore49.0
Impact factor32.1
ISSN15487091, 15487105
Краткое описание

Advances in electron microscopy, image segmentation and computational infrastructure have given rise to large-scale and richly annotated connectomic datasets, which are increasingly shared across communities. To enable collaboration, users need to be able to concurrently create annotations and correct errors in the automated segmentation by proofreading. In large datasets, every proofreading edit relabels cell identities of millions of voxels and thousands of annotations like synapses. For analysis, users require immediate and reproducible access to this changing and expanding data landscape. Here we present the Connectome Annotation Versioning Engine (CAVE), a computational infrastructure that provides scalable solutions for proofreading and flexible annotation support for fast analysis queries at arbitrary time points. Deployed as a suite of web services, CAVE empowers distributed communities to perform reproducible connectome analysis in up to petascale datasets (~1 mm3) while proofreading and annotating is ongoing.

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ГОСТ |
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Dorkenwald S. et al. CAVE: Connectome Annotation Versioning Engine // Nature Methods. 2025. Vol. 22. No. 5. pp. 1112-1120.
ГОСТ со всеми авторами (до 50) Скопировать
Dorkenwald S. et al. CAVE: Connectome Annotation Versioning Engine // Nature Methods. 2025. Vol. 22. No. 5. pp. 1112-1120.
RIS |
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TY - JOUR
DO - 10.1038/s41592-024-02426-z
UR - https://www.nature.com/articles/s41592-024-02426-z
TI - CAVE: Connectome Annotation Versioning Engine
T2 - Nature Methods
AU - Dorkenwald, Sven
AU - Schneider Mizell, Casey
AU - BRITTAIN, DERRICK
AU - Halageri, Akhilesh
AU - Jordan, Chris
AU - Kemnitz, Nico
AU - Castro, Manual A.
AU - Silversmith, William
AU - Maitin-Shephard, Jeremy
AU - Troidl, Jakob
AU - Pfister, Hanspeter
AU - Gillet, Valentin
AU - Xenes, Daniel
AU - Bae, J Alexander
AU - Bodor, Agnes L
AU - Buchanan, Joann
AU - Bumbarger, Daniel J.
AU - Elabbady, Leila
AU - Jia, Zhen
AU - Kapner, Daniel
AU - Kinn, Sam
AU - Lee, Kisuk
AU - Li, Kai
AU - Ran, Lu
AU - Macrina, Thomas
AU - Mahalingam, Gayathri
AU - Mitchell, Eric
AU - Mondal, Shanka Subhra
AU - Shang, Mu
AU - Nehoran, Barak
AU - Popovych, Sergiy
AU - Takeno, Marc
AU - Torres, Russel
AU - Turner, Nicholas L
AU - Wong, William
AU - Wu, Jingpeng
AU - Yin, Wenjing
AU - Yu, Szi-chieh
AU - Reid, R. J. O.
AU - Maçarico Da Costa, Nuno
AU - Seung, H. Sebastian
AU - Collman, F.
PY - 2025
DA - 2025/04/09
PB - Springer Nature
SP - 1112-1120
IS - 5
VL - 22
SN - 1548-7091
SN - 1548-7105
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2025_Dorkenwald,
author = {Sven Dorkenwald and Casey Schneider Mizell and DERRICK BRITTAIN and Akhilesh Halageri and Chris Jordan and Nico Kemnitz and Manual A. Castro and William Silversmith and Jeremy Maitin-Shephard and Jakob Troidl and Hanspeter Pfister and Valentin Gillet and Daniel Xenes and J Alexander Bae and Agnes L Bodor and Joann Buchanan and Daniel J. Bumbarger and Leila Elabbady and Zhen Jia and Daniel Kapner and Sam Kinn and Kisuk Lee and Kai Li and Lu Ran and Thomas Macrina and Gayathri Mahalingam and Eric Mitchell and Shanka Subhra Mondal and Mu Shang and Barak Nehoran and Sergiy Popovych and Marc Takeno and Russel Torres and Nicholas L Turner and William Wong and Jingpeng Wu and Wenjing Yin and Szi-chieh Yu and R. J. O. Reid and Nuno Maçarico Da Costa and H. Sebastian Seung and F. Collman and others},
title = {CAVE: Connectome Annotation Versioning Engine},
journal = {Nature Methods},
year = {2025},
volume = {22},
publisher = {Springer Nature},
month = {apr},
url = {https://www.nature.com/articles/s41592-024-02426-z},
number = {5},
pages = {1112--1120},
doi = {10.1038/s41592-024-02426-z}
}
MLA
Цитировать
Dorkenwald, Sven, et al. “CAVE: Connectome Annotation Versioning Engine.” Nature Methods, vol. 22, no. 5, Apr. 2025, pp. 1112-1120. https://www.nature.com/articles/s41592-024-02426-z.